| Full name: cytochrome c oxidase subunit 8A | Alias Symbol: COX8-2|COX8L|VIII-L|COX|VIII | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 1351 | HGNC ID: HGNC:2294 | Ensembl Gene: ENSG00000176340 | OMIM ID: 123870 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of COX8A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX8A | 1351 | 201119_s_at | -0.3019 | 0.2527 | |
| GSE20347 | COX8A | 1351 | 201119_s_at | -0.4169 | 0.0236 | |
| GSE23400 | COX8A | 1351 | 201119_s_at | -0.1915 | 0.0076 | |
| GSE26886 | COX8A | 1351 | 201119_s_at | -0.4048 | 0.0815 | |
| GSE29001 | COX8A | 1351 | 201119_s_at | -0.5455 | 0.2090 | |
| GSE38129 | COX8A | 1351 | 201119_s_at | -0.2575 | 0.0627 | |
| GSE45670 | COX8A | 1351 | 201119_s_at | -0.1540 | 0.2362 | |
| GSE53622 | COX8A | 1351 | 27383 | -0.5826 | 0.0000 | |
| GSE53624 | COX8A | 1351 | 27383 | -0.1578 | 0.0057 | |
| GSE63941 | COX8A | 1351 | 201119_s_at | 0.4244 | 0.3092 | |
| GSE77861 | COX8A | 1351 | 201119_s_at | -0.1666 | 0.3339 | |
| GSE97050 | COX8A | 1351 | A_23_P52639 | -0.1260 | 0.5110 | |
| SRP007169 | COX8A | 1351 | RNAseq | -1.2474 | 0.0002 | |
| SRP008496 | COX8A | 1351 | RNAseq | -1.2249 | 0.0000 | |
| SRP064894 | COX8A | 1351 | RNAseq | -0.3125 | 0.3263 | |
| SRP133303 | COX8A | 1351 | RNAseq | -0.3782 | 0.0826 | |
| SRP159526 | COX8A | 1351 | RNAseq | -0.2608 | 0.2623 | |
| SRP193095 | COX8A | 1351 | RNAseq | -0.6685 | 0.0000 | |
| SRP219564 | COX8A | 1351 | RNAseq | -0.3880 | 0.2598 | |
| TCGA | COX8A | 1351 | RNAseq | -0.0654 | 0.1581 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by COX8A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COX8A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX8A | 1351 | 6 | 5 | 19 | |
| GSE20123 | COX8A | 1351 | 6 | 5 | 19 | |
| GSE43470 | COX8A | 1351 | 1 | 3 | 39 | |
| GSE46452 | COX8A | 1351 | 8 | 4 | 47 | |
| GSE47630 | COX8A | 1351 | 3 | 7 | 30 | |
| GSE54993 | COX8A | 1351 | 3 | 0 | 67 | |
| GSE54994 | COX8A | 1351 | 5 | 5 | 43 | |
| GSE60625 | COX8A | 1351 | 0 | 4 | 7 | |
| GSE74703 | COX8A | 1351 | 1 | 1 | 34 | |
| GSE74704 | COX8A | 1351 | 4 | 3 | 13 | |
| TCGA | COX8A | 1351 | 17 | 10 | 69 |
Total number of gains: 54; Total number of losses: 47; Total Number of normals: 387.
Somatic mutations of COX8A:
Generating mutation plots.
Highly correlated genes for COX8A:
Showing top 20/227 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX8A | JMJD8 | 0.864786 | 3 | 0 | 3 |
| COX8A | SPSB3 | 0.697083 | 3 | 0 | 3 |
| COX8A | HRCT1 | 0.690693 | 3 | 0 | 3 |
| COX8A | HEBP1 | 0.687993 | 3 | 0 | 3 |
| COX8A | OR4D2 | 0.68052 | 3 | 0 | 3 |
| COX8A | NYAP1 | 0.6757 | 3 | 0 | 3 |
| COX8A | CABP7 | 0.675493 | 3 | 0 | 3 |
| COX8A | DNAJB8 | 0.673593 | 3 | 0 | 3 |
| COX8A | STK16 | 0.661756 | 4 | 0 | 4 |
| COX8A | NUDT16L1 | 0.657033 | 4 | 0 | 3 |
| COX8A | SCN2B | 0.656634 | 4 | 0 | 4 |
| COX8A | ACAT2 | 0.656485 | 4 | 0 | 3 |
| COX8A | SHOC2 | 0.645522 | 4 | 0 | 3 |
| COX8A | MAFG | 0.643051 | 4 | 0 | 3 |
| COX8A | ARHGDIG | 0.637303 | 4 | 0 | 3 |
| COX8A | ADH6 | 0.6344 | 5 | 0 | 4 |
| COX8A | TMEM125 | 0.631426 | 4 | 0 | 3 |
| COX8A | PRSS27 | 0.630313 | 5 | 0 | 4 |
| COX8A | TRNP1 | 0.626244 | 3 | 0 | 3 |
| COX8A | BTBD10 | 0.623916 | 4 | 0 | 3 |
For details and further investigation, click here
