| Full name: sodium voltage-gated channel beta subunit 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 6327 | HGNC ID: HGNC:10589 | Ensembl Gene: ENSG00000149575 | OMIM ID: 601327 |
| Drug and gene relationship at DGIdb | |||
Expression of SCN2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN2B | 6327 | 210364_at | -0.1686 | 0.4278 | |
| GSE20347 | SCN2B | 6327 | 210364_at | -0.1098 | 0.2117 | |
| GSE23400 | SCN2B | 6327 | 210363_s_at | -0.0953 | 0.0068 | |
| GSE26886 | SCN2B | 6327 | 210364_at | 0.3336 | 0.0432 | |
| GSE29001 | SCN2B | 6327 | 210364_at | 0.0163 | 0.9154 | |
| GSE38129 | SCN2B | 6327 | 210364_at | -0.1031 | 0.1994 | |
| GSE45670 | SCN2B | 6327 | 210364_at | -0.1446 | 0.1153 | |
| GSE53622 | SCN2B | 6327 | 149711 | -1.1224 | 0.0000 | |
| GSE53624 | SCN2B | 6327 | 149711 | -1.3292 | 0.0000 | |
| GSE63941 | SCN2B | 6327 | 210364_at | -0.1029 | 0.5095 | |
| GSE77861 | SCN2B | 6327 | 210364_at | -0.1626 | 0.2083 | |
| GSE97050 | SCN2B | 6327 | A_32_P187571 | -0.0109 | 0.9805 | |
| SRP064894 | SCN2B | 6327 | RNAseq | -0.4773 | 0.2835 | |
| SRP133303 | SCN2B | 6327 | RNAseq | -0.9440 | 0.0016 | |
| SRP159526 | SCN2B | 6327 | RNAseq | -1.8118 | 0.0017 | |
| SRP219564 | SCN2B | 6327 | RNAseq | -1.2166 | 0.0880 | |
| TCGA | SCN2B | 6327 | RNAseq | -1.3150 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by SCN2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCN2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN2B | 6327 | 2 | 11 | 17 | |
| GSE20123 | SCN2B | 6327 | 2 | 11 | 17 | |
| GSE43470 | SCN2B | 6327 | 2 | 9 | 32 | |
| GSE46452 | SCN2B | 6327 | 3 | 26 | 30 | |
| GSE47630 | SCN2B | 6327 | 2 | 19 | 19 | |
| GSE54993 | SCN2B | 6327 | 10 | 0 | 60 | |
| GSE54994 | SCN2B | 6327 | 6 | 19 | 28 | |
| GSE60625 | SCN2B | 6327 | 0 | 3 | 8 | |
| GSE74703 | SCN2B | 6327 | 1 | 6 | 29 | |
| GSE74704 | SCN2B | 6327 | 1 | 7 | 12 | |
| TCGA | SCN2B | 6327 | 6 | 49 | 41 |
Total number of gains: 35; Total number of losses: 160; Total Number of normals: 293.
Somatic mutations of SCN2B:
Generating mutation plots.
Highly correlated genes for SCN2B:
Showing top 20/585 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN2B | RIMS4 | 0.797428 | 3 | 0 | 3 |
| SCN2B | TMEM179 | 0.793728 | 3 | 0 | 3 |
| SCN2B | DUSP15 | 0.78958 | 3 | 0 | 3 |
| SCN2B | NKAIN4 | 0.787574 | 3 | 0 | 3 |
| SCN2B | HRCT1 | 0.780354 | 3 | 0 | 3 |
| SCN2B | CPA5 | 0.749472 | 3 | 0 | 3 |
| SCN2B | PHGR1 | 0.74384 | 3 | 0 | 3 |
| SCN2B | REG3A | 0.741625 | 4 | 0 | 4 |
| SCN2B | LELP1 | 0.739269 | 4 | 0 | 3 |
| SCN2B | IGFL2 | 0.734032 | 3 | 0 | 3 |
| SCN2B | B3GNT8 | 0.729056 | 3 | 0 | 3 |
| SCN2B | IGFN1 | 0.72884 | 3 | 0 | 3 |
| SCN2B | LRSAM1 | 0.714813 | 3 | 0 | 3 |
| SCN2B | GPR26 | 0.711343 | 3 | 0 | 3 |
| SCN2B | WNT9A | 0.708466 | 3 | 0 | 3 |
| SCN2B | ASB6 | 0.708015 | 3 | 0 | 3 |
| SCN2B | SLC35F3 | 0.705944 | 3 | 0 | 3 |
| SCN2B | SLC4A9 | 0.698791 | 5 | 0 | 5 |
| SCN2B | CCDC114 | 0.697833 | 4 | 0 | 4 |
| SCN2B | KCNF1 | 0.695853 | 5 | 0 | 4 |
For details and further investigation, click here
