| Full name: carboxypeptidase B2 | Alias Symbol: CPU|PCPB|TAFI | ||
| Type: protein-coding gene | Cytoband: 13q14.13 | ||
| Entrez ID: 1361 | HGNC ID: HGNC:2300 | Ensembl Gene: ENSG00000080618 | OMIM ID: 603101 |
| Drug and gene relationship at DGIdb | |||
CPB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of CPB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPB2 | 1361 | 206651_s_at | 0.1388 | 0.5013 | |
| GSE20347 | CPB2 | 1361 | 206651_s_at | 0.0520 | 0.4579 | |
| GSE23400 | CPB2 | 1361 | 206651_s_at | 0.0051 | 0.8844 | |
| GSE26886 | CPB2 | 1361 | 206651_s_at | 0.9111 | 0.0043 | |
| GSE29001 | CPB2 | 1361 | 206651_s_at | 0.1107 | 0.3409 | |
| GSE38129 | CPB2 | 1361 | 206651_s_at | 0.0193 | 0.7420 | |
| GSE45670 | CPB2 | 1361 | 206651_s_at | 0.0457 | 0.5817 | |
| GSE63941 | CPB2 | 1361 | 206651_s_at | 0.0828 | 0.5082 | |
| GSE77861 | CPB2 | 1361 | 206651_s_at | 0.0116 | 0.9041 | |
| TCGA | CPB2 | 1361 | RNAseq | 1.6241 | 0.0898 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CPB2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CPB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPB2 | 1361 | 0 | 14 | 16 | |
| GSE20123 | CPB2 | 1361 | 0 | 13 | 17 | |
| GSE43470 | CPB2 | 1361 | 3 | 13 | 27 | |
| GSE46452 | CPB2 | 1361 | 0 | 33 | 26 | |
| GSE47630 | CPB2 | 1361 | 2 | 27 | 11 | |
| GSE54993 | CPB2 | 1361 | 12 | 2 | 56 | |
| GSE54994 | CPB2 | 1361 | 1 | 16 | 36 | |
| GSE60625 | CPB2 | 1361 | 0 | 3 | 8 | |
| GSE74703 | CPB2 | 1361 | 3 | 10 | 23 | |
| GSE74704 | CPB2 | 1361 | 0 | 10 | 10 | |
| TCGA | CPB2 | 1361 | 7 | 40 | 49 |
Total number of gains: 28; Total number of losses: 181; Total Number of normals: 279.
Somatic mutations of CPB2:
Generating mutation plots.
Highly correlated genes for CPB2:
Showing top 20/148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPB2 | CHST14 | 0.727489 | 3 | 0 | 3 |
| CPB2 | SLC30A10 | 0.712229 | 3 | 0 | 3 |
| CPB2 | INSL5 | 0.700661 | 3 | 0 | 3 |
| CPB2 | GHDC | 0.682049 | 3 | 0 | 3 |
| CPB2 | ESRRG | 0.670253 | 3 | 0 | 3 |
| CPB2 | LNP1 | 0.656908 | 3 | 0 | 3 |
| CPB2 | PSMC3IP | 0.654508 | 3 | 0 | 3 |
| CPB2 | ECE1 | 0.652735 | 3 | 0 | 3 |
| CPB2 | ADPRM | 0.642096 | 3 | 0 | 3 |
| CPB2 | GFRA3 | 0.634572 | 4 | 0 | 3 |
| CPB2 | PRM3 | 0.633339 | 3 | 0 | 3 |
| CPB2 | KLHL32 | 0.630924 | 3 | 0 | 3 |
| CPB2 | OTC | 0.628144 | 4 | 0 | 4 |
| CPB2 | WNT2 | 0.622459 | 4 | 0 | 3 |
| CPB2 | FGFR1 | 0.616408 | 3 | 0 | 3 |
| CPB2 | C2orf83 | 0.610639 | 5 | 0 | 5 |
| CPB2 | RSBN1L | 0.61055 | 4 | 0 | 4 |
| CPB2 | GPR22 | 0.60972 | 4 | 0 | 4 |
| CPB2 | LEFTY1 | 0.606906 | 4 | 0 | 3 |
| CPB2 | HTR1E | 0.605857 | 3 | 0 | 3 |
For details and further investigation, click here
