| Full name: DEAD/H-box helicase 11 | Alias Symbol: CHLR1|KRG2|CHL1|ChlR1|WABS | ||
| Type: protein-coding gene | Cytoband: 12p11.21 | ||
| Entrez ID: 1663 | HGNC ID: HGNC:2736 | Ensembl Gene: ENSG00000013573 | OMIM ID: 601150 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX11 | 1663 | 208159_x_at | 0.8911 | 0.0357 | |
| GSE20347 | DDX11 | 1663 | 208159_x_at | 1.0615 | 0.0000 | |
| GSE23400 | DDX11 | 1663 | 208159_x_at | 0.7056 | 0.0000 | |
| GSE26886 | DDX11 | 1663 | 208159_x_at | 0.5476 | 0.0477 | |
| GSE29001 | DDX11 | 1663 | 208159_x_at | 0.9093 | 0.0063 | |
| GSE38129 | DDX11 | 1663 | 208159_x_at | 0.8694 | 0.0000 | |
| GSE45670 | DDX11 | 1663 | 208159_x_at | 0.7517 | 0.0012 | |
| GSE53622 | DDX11 | 1663 | 93515 | -0.1241 | 0.3538 | |
| GSE53624 | DDX11 | 1663 | 93515 | -1.4462 | 0.0000 | |
| GSE63941 | DDX11 | 1663 | 208159_x_at | 1.7810 | 0.0037 | |
| GSE77861 | DDX11 | 1663 | 208149_x_at | 0.8612 | 0.0032 | |
| GSE97050 | DDX11 | 1663 | A_23_P203947 | 0.8408 | 0.1399 | |
| SRP007169 | DDX11 | 1663 | RNAseq | 4.8114 | 0.0000 | |
| SRP008496 | DDX11 | 1663 | RNAseq | 3.5754 | 0.0000 | |
| SRP064894 | DDX11 | 1663 | RNAseq | 1.4144 | 0.0000 | |
| SRP133303 | DDX11 | 1663 | RNAseq | 1.1279 | 0.0005 | |
| SRP159526 | DDX11 | 1663 | RNAseq | 1.9822 | 0.0019 | |
| SRP193095 | DDX11 | 1663 | RNAseq | 1.3575 | 0.0000 | |
| SRP219564 | DDX11 | 1663 | RNAseq | 1.4659 | 0.0005 | |
| TCGA | DDX11 | 1663 | RNAseq | 0.4077 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 1.
Survival by DDX11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX11 | 1663 | 10 | 2 | 18 | |
| GSE20123 | DDX11 | 1663 | 10 | 2 | 18 | |
| GSE43470 | DDX11 | 1663 | 8 | 4 | 31 | |
| GSE46452 | DDX11 | 1663 | 10 | 1 | 48 | |
| GSE47630 | DDX11 | 1663 | 12 | 1 | 27 | |
| GSE54993 | DDX11 | 1663 | 0 | 9 | 61 | |
| GSE54994 | DDX11 | 1663 | 8 | 2 | 43 | |
| GSE60625 | DDX11 | 1663 | 0 | 1 | 10 | |
| GSE74703 | DDX11 | 1663 | 7 | 3 | 26 | |
| GSE74704 | DDX11 | 1663 | 6 | 0 | 14 | |
| TCGA | DDX11 | 1663 | 41 | 6 | 49 |
Total number of gains: 112; Total number of losses: 31; Total Number of normals: 345.
Somatic mutations of DDX11:
Generating mutation plots.
Highly correlated genes for DDX11:
Showing top 20/791 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX11 | CRTC2 | 0.846108 | 3 | 0 | 3 |
| DDX11 | SCAF1 | 0.769949 | 3 | 0 | 3 |
| DDX11 | ZFYVE27 | 0.759637 | 4 | 0 | 4 |
| DDX11 | SMCR8 | 0.748589 | 3 | 0 | 3 |
| DDX11 | ST6GAL1 | 0.747685 | 3 | 0 | 3 |
| DDX11 | RAD54L | 0.744676 | 10 | 0 | 10 |
| DDX11 | CXCL3 | 0.737717 | 3 | 0 | 3 |
| DDX11 | SMKR1 | 0.736114 | 3 | 0 | 3 |
| DDX11 | RNPS1 | 0.734923 | 9 | 0 | 9 |
| DDX11 | IL1B | 0.730975 | 3 | 0 | 3 |
| DDX11 | ZNF384 | 0.729003 | 10 | 0 | 10 |
| DDX11 | CPNE2 | 0.72688 | 5 | 0 | 4 |
| DDX11 | ZAP70 | 0.726052 | 3 | 0 | 3 |
| DDX11 | DDA1 | 0.722404 | 4 | 0 | 3 |
| DDX11 | KREMEN1 | 0.721875 | 3 | 0 | 3 |
| DDX11 | SRRT | 0.720322 | 10 | 0 | 9 |
| DDX11 | PLEKHH1 | 0.718638 | 3 | 0 | 3 |
| DDX11 | CDCA2 | 0.718105 | 5 | 0 | 4 |
| DDX11 | CMTM4 | 0.712996 | 5 | 0 | 5 |
| DDX11 | KIF18B | 0.710854 | 9 | 0 | 9 |
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