| Full name: C-terminal Src kinase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 1445 | HGNC ID: HGNC:2444 | Ensembl Gene: ENSG00000103653 | OMIM ID: 124095 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CSK involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
Expression of CSK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CSK | 1445 | 202329_at | -0.1038 | 0.9228 | |
| GSE20347 | CSK | 1445 | 202329_at | -0.7664 | 0.0000 | |
| GSE23400 | CSK | 1445 | 202329_at | -0.5535 | 0.0000 | |
| GSE26886 | CSK | 1445 | 202329_at | -1.1264 | 0.0000 | |
| GSE29001 | CSK | 1445 | 202329_at | -0.6268 | 0.0230 | |
| GSE38129 | CSK | 1445 | 202329_at | -0.3436 | 0.1479 | |
| GSE45670 | CSK | 1445 | 202329_at | -0.3390 | 0.0690 | |
| GSE53622 | CSK | 1445 | 47948 | -0.7099 | 0.0000 | |
| GSE53624 | CSK | 1445 | 47948 | -0.9044 | 0.0000 | |
| GSE63941 | CSK | 1445 | 202329_at | 0.7395 | 0.1064 | |
| GSE77861 | CSK | 1445 | 202329_at | -0.6913 | 0.0140 | |
| GSE97050 | CSK | 1445 | A_23_P152024 | 0.3886 | 0.5556 | |
| SRP007169 | CSK | 1445 | RNAseq | -2.1553 | 0.0000 | |
| SRP008496 | CSK | 1445 | RNAseq | -2.1900 | 0.0000 | |
| SRP064894 | CSK | 1445 | RNAseq | -0.7388 | 0.0003 | |
| SRP133303 | CSK | 1445 | RNAseq | -0.9151 | 0.0000 | |
| SRP159526 | CSK | 1445 | RNAseq | -0.8421 | 0.0000 | |
| SRP193095 | CSK | 1445 | RNAseq | -0.6751 | 0.0000 | |
| SRP219564 | CSK | 1445 | RNAseq | -0.7575 | 0.1167 | |
| TCGA | CSK | 1445 | RNAseq | 0.1443 | 0.0070 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CSK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CSK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CSK | 1445 | 8 | 1 | 21 | |
| GSE20123 | CSK | 1445 | 8 | 1 | 21 | |
| GSE43470 | CSK | 1445 | 4 | 6 | 33 | |
| GSE46452 | CSK | 1445 | 3 | 7 | 49 | |
| GSE47630 | CSK | 1445 | 8 | 10 | 22 | |
| GSE54993 | CSK | 1445 | 5 | 6 | 59 | |
| GSE54994 | CSK | 1445 | 5 | 7 | 41 | |
| GSE60625 | CSK | 1445 | 4 | 0 | 7 | |
| GSE74703 | CSK | 1445 | 4 | 3 | 29 | |
| GSE74704 | CSK | 1445 | 4 | 1 | 15 | |
| TCGA | CSK | 1445 | 14 | 15 | 67 |
Total number of gains: 67; Total number of losses: 57; Total Number of normals: 364.
Somatic mutations of CSK:
Generating mutation plots.
Highly correlated genes for CSK:
Showing top 20/1417 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CSK | ARHGAP27 | 0.7785 | 7 | 0 | 7 |
| CSK | CYSRT1 | 0.766471 | 5 | 0 | 5 |
| CSK | ULK3 | 0.75608 | 9 | 0 | 9 |
| CSK | BLNK | 0.748535 | 10 | 0 | 10 |
| CSK | FAM95B1 | 0.748094 | 3 | 0 | 3 |
| CSK | ELOVL1 | 0.748049 | 3 | 0 | 3 |
| CSK | MFSD5 | 0.744756 | 11 | 0 | 11 |
| CSK | ZDHHC13 | 0.743683 | 10 | 0 | 10 |
| CSK | DENND2D | 0.739466 | 10 | 0 | 10 |
| CSK | RASSF5 | 0.734282 | 7 | 0 | 7 |
| CSK | LYNX1 | 0.734111 | 5 | 0 | 5 |
| CSK | SLC16A6 | 0.731752 | 10 | 0 | 9 |
| CSK | VSIG10L | 0.730168 | 5 | 0 | 5 |
| CSK | SH3GL1 | 0.726426 | 11 | 0 | 10 |
| CSK | MACC1 | 0.722955 | 7 | 0 | 7 |
| CSK | MMEL1 | 0.721952 | 4 | 0 | 4 |
| CSK | RAB25 | 0.719176 | 11 | 0 | 10 |
| CSK | KLB | 0.717335 | 6 | 0 | 6 |
| CSK | ARAP2 | 0.716811 | 3 | 0 | 3 |
| CSK | DNAJB6 | 0.715757 | 3 | 0 | 3 |
For details and further investigation, click here
