CTBP1

 

Full name: C-terminal binding protein 1 Alias Symbol: BARS
Type: protein-coding gene Cytoband: 4p16.3
Entrez ID: 1487 HGNC ID: HGNC:2494 Ensembl Gene: ENSG00000159692 OMIM ID: 602618
Drug and gene relationship at DGIdb
Screen Evidence:

 

CTBP1 involved pathways:

KEGG pathway Description View
hsa04310Wnt signaling pathway
hsa04330Notch signaling pathway
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia

 

Expression of CTBP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CTBP1 1487 212863_x_at 0.3771 0.3353
GSE20347 CTBP1 1487 212863_x_at -0.0781 0.5799
GSE23400 CTBP1 1487 212863_x_at 0.1182 0.0683
GSE26886 CTBP1 1487 212863_x_at -0.4045 0.0466
GSE29001 CTBP1 1487 212863_x_at 0.2396 0.5144
GSE38129 CTBP1 1487 212863_x_at -0.0470 0.6867
GSE45670 CTBP1 1487 212863_x_at 0.1063 0.4118
GSE53622 CTBP1 1487 15702 0.1280 0.0300
GSE53624 CTBP1 1487 87663 -1.5219 0.0000
GSE63941 CTBP1 1487 212863_x_at -0.2754 0.3068
GSE77861 CTBP1 1487 212863_x_at 0.0097 0.9778
GSE97050 CTBP1 1487 A_33_P3357979 0.1609 0.4480
SRP007169 CTBP1 1487 RNAseq 0.2312 0.5300
SRP008496 CTBP1 1487 RNAseq 0.4195 0.1267
SRP064894 CTBP1 1487 RNAseq 0.4798 0.0284
SRP133303 CTBP1 1487 RNAseq -0.0461 0.6607
SRP159526 CTBP1 1487 RNAseq 0.0983 0.7531
SRP193095 CTBP1 1487 RNAseq -0.1331 0.2525
SRP219564 CTBP1 1487 RNAseq 0.2054 0.4910
TCGA CTBP1 1487 RNAseq -0.0205 0.6365

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by CTBP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CTBP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CTBP1 1487 0 16 14
GSE20123 CTBP1 1487 0 16 14
GSE43470 CTBP1 1487 0 17 26
GSE46452 CTBP1 1487 1 36 22
GSE47630 CTBP1 1487 2 19 19
GSE54993 CTBP1 1487 11 0 59
GSE54994 CTBP1 1487 3 12 38
GSE60625 CTBP1 1487 0 0 11
GSE74703 CTBP1 1487 0 13 23
GSE74704 CTBP1 1487 0 8 12
TCGA CTBP1 1487 9 47 40

Total number of gains: 26; Total number of losses: 184; Total Number of normals: 278.  

 

Somatic mutations of CTBP1:

 

Generating mutation plots.

 

Highly correlated genes for CTBP1:

 

Showing top 20/54 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CTBP1HDAC110.645183404
CTBP1WDR60.638086404
CTBP1UBXN80.634836303
CTBP1RYR10.630807404
CTBP1ACOX30.628525303
CTBP1FAM193A0.6190541007
CTBP1SLC2A4RG0.612863403
CTBP1ZDHHC60.611858303
CTBP1WLS0.604737303
CTBP1ABCD40.604507504
CTBP1GNB20.601817303
CTBP1NOP140.598896504
CTBP1AAK10.597233303
CTBP1GALE0.595333303
CTBP1TSTA30.591184403
CTBP1SGSH0.588033504
CTBP1BIN30.587689403
CTBP1PIGZ0.587135303
CTBP1CDK2AP20.586568403
CTBP1B4GALT30.58545404

For details and further investigation, click here