GNB2

 

Full name: G protein subunit beta 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 2783 HGNC ID: HGNC:4398 Ensembl Gene: ENSG00000172354 OMIM ID: 139390
Drug and gene relationship at DGIdb
Screen Evidence:

 

GNB2 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNB2 2783 200852_x_at 0.1959 0.7396
GSE20347 GNB2 2783 200852_x_at -0.3943 0.0185
GSE23400 GNB2 2783 200852_x_at -0.2556 0.0028
GSE26886 GNB2 2783 200852_x_at -0.4731 0.0613
GSE29001 GNB2 2783 200852_x_at -0.8725 0.0194
GSE38129 GNB2 2783 200852_x_at -0.1178 0.4289
GSE45670 GNB2 2783 200852_x_at 0.1698 0.3479
GSE53622 GNB2 2783 6551 0.1242 0.0262
GSE53624 GNB2 2783 6551 0.0349 0.5409
GSE63941 GNB2 2783 200852_x_at 0.4315 0.2951
GSE77861 GNB2 2783 200852_x_at -0.1263 0.6099
GSE97050 GNB2 2783 A_23_P82296 0.1679 0.4878
SRP007169 GNB2 2783 RNAseq -1.9411 0.0000
SRP008496 GNB2 2783 RNAseq -1.9085 0.0000
SRP064894 GNB2 2783 RNAseq -0.2064 0.4010
SRP133303 GNB2 2783 RNAseq 0.0145 0.9309
SRP159526 GNB2 2783 RNAseq -0.5579 0.0449
SRP193095 GNB2 2783 RNAseq -0.1381 0.3886
SRP219564 GNB2 2783 RNAseq -0.0969 0.6898
TCGA GNB2 2783 RNAseq 0.0948 0.0331

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by GNB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNB2 2783 13 0 17
GSE20123 GNB2 2783 13 0 17
GSE43470 GNB2 2783 7 2 34
GSE46452 GNB2 2783 11 1 47
GSE47630 GNB2 2783 7 3 30
GSE54993 GNB2 2783 1 9 60
GSE54994 GNB2 2783 16 3 34
GSE60625 GNB2 2783 0 0 11
GSE74703 GNB2 2783 7 1 28
GSE74704 GNB2 2783 9 0 11
TCGA GNB2 2783 53 6 37

Total number of gains: 137; Total number of losses: 25; Total Number of normals: 326.  

 

Somatic mutations of GNB2:

 

Generating mutation plots.

 

Highly correlated genes for GNB2:

 

Showing top 20/287 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNB2RPUSD10.733055303
GNB2BROX0.727489303
GNB2ARPC1A0.70200311011
GNB2SUFU0.681839303
GNB2CCDC1370.675808404
GNB2INSL40.6743303
GNB2SLC44A40.6641303
GNB2KRT180.657996403
GNB2ARF50.649155907
GNB2RNFT20.643385303
GNB2MRPL370.636717606
GNB2POLR3K0.635651303
GNB2CORO70.632867303
GNB2RABEP20.629145403
GNB2POP70.623249706
GNB2USP380.62116303
GNB2DIP2B0.621068303
GNB2MECOM0.618394303
GNB2MLYCD0.616247303
GNB2YIPF10.611934605

For details and further investigation, click here