CTCF

 

Full name: CCCTC-binding factor Alias Symbol: 
Type: protein-coding gene Cytoband: 16q22.1
Entrez ID: 10664 HGNC ID: HGNC:13723 Ensembl Gene: ENSG00000102974 OMIM ID: 604167
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CTCF:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CTCF 10664 202521_at 0.1403 0.7024
GSE20347 CTCF 10664 202521_at 0.2813 0.0004
GSE23400 CTCF 10664 202521_at 0.2670 0.0001
GSE26886 CTCF 10664 202521_at 0.2048 0.1847
GSE29001 CTCF 10664 202521_at 0.1878 0.5995
GSE38129 CTCF 10664 202521_at 0.2540 0.0002
GSE45670 CTCF 10664 202521_at 0.1263 0.2989
GSE53622 CTCF 10664 63977 0.3231 0.0000
GSE53624 CTCF 10664 63977 0.2865 0.0402
GSE63941 CTCF 10664 202521_at 0.5813 0.0287
GSE77861 CTCF 10664 202521_at 0.1317 0.5336
GSE97050 CTCF 10664 A_24_P347704 0.5148 0.1415
SRP007169 CTCF 10664 RNAseq 0.6694 0.0643
SRP008496 CTCF 10664 RNAseq 0.3920 0.0907
SRP064894 CTCF 10664 RNAseq 0.0801 0.5346
SRP133303 CTCF 10664 RNAseq 0.3091 0.0179
SRP159526 CTCF 10664 RNAseq 0.3536 0.0637
SRP193095 CTCF 10664 RNAseq 0.1159 0.0897
SRP219564 CTCF 10664 RNAseq 0.0803 0.7083
TCGA CTCF 10664 RNAseq 0.0791 0.0855

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CTCF expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CTCF:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CTCF 10664 9 2 19
GSE20123 CTCF 10664 9 2 19
GSE43470 CTCF 10664 1 9 33
GSE46452 CTCF 10664 38 1 20
GSE47630 CTCF 10664 11 8 21
GSE54993 CTCF 10664 2 4 64
GSE54994 CTCF 10664 8 10 35
GSE60625 CTCF 10664 4 0 7
GSE74703 CTCF 10664 1 6 29
GSE74704 CTCF 10664 5 1 14
TCGA CTCF 10664 29 13 54

Total number of gains: 117; Total number of losses: 56; Total Number of normals: 315.  

 

Somatic mutations of CTCF:

 

Generating mutation plots.

 

Highly correlated genes for CTCF:

 

Showing top 20/1086 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CTCFINTS120.787336403
CTCFUCHL50.775255303
CTCFCEP440.775169303
CTCFZBTB90.773294404
CTCFGABPA0.767125303
CTCFMYOF0.765987303
CTCFTRIP40.760103303
CTCFEIF3I0.748911303
CTCFSRRM10.748011303
CTCFKLHL240.74509303
CTCFGTF2H30.739271303
CTCFCOG10.735997303
CTCFCHCHD50.730832403
CTCFFOXN30.726575303
CTCFPPCS0.721657303
CTCFTHUMPD10.721238404
CTCFUBE2N0.720282404
CTCFPPP2R5E0.71789303
CTCFNOL90.716351403
CTCFATG2B0.714643303

For details and further investigation, click here