G3BP1

 

Full name: G3BP stress granule assembly factor 1 Alias Symbol: HDH-VIII|G3BP
Type: protein-coding gene Cytoband: 5q33.1
Entrez ID: 10146 HGNC ID: HGNC:30292 Ensembl Gene: ENSG00000145907 OMIM ID: 608431
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of G3BP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 G3BP1 10146 201503_at 0.6754 0.0647
GSE20347 G3BP1 10146 201503_at 0.2600 0.0922
GSE23400 G3BP1 10146 201514_s_at 0.3958 0.0000
GSE26886 G3BP1 10146 201503_at 0.2820 0.0542
GSE29001 G3BP1 10146 201503_at 0.1357 0.7302
GSE38129 G3BP1 10146 201503_at 0.4386 0.0017
GSE45670 G3BP1 10146 201503_at 0.6431 0.0000
GSE53622 G3BP1 10146 56269 0.0076 0.8971
GSE53624 G3BP1 10146 56269 0.2695 0.0000
GSE63941 G3BP1 10146 201503_at 0.0329 0.9383
GSE77861 G3BP1 10146 201503_at 0.3051 0.0871
GSE97050 G3BP1 10146 A_33_P3331242 0.2647 0.3564
SRP007169 G3BP1 10146 RNAseq 0.3569 0.2181
SRP008496 G3BP1 10146 RNAseq 0.3886 0.0049
SRP064894 G3BP1 10146 RNAseq 0.2699 0.1575
SRP133303 G3BP1 10146 RNAseq 0.3480 0.0155
SRP159526 G3BP1 10146 RNAseq 0.1976 0.4877
SRP193095 G3BP1 10146 RNAseq 0.1201 0.2226
SRP219564 G3BP1 10146 RNAseq 0.4118 0.2939
TCGA G3BP1 10146 RNAseq 0.2075 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by G3BP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of G3BP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 G3BP1 10146 1 12 17
GSE20123 G3BP1 10146 1 12 17
GSE43470 G3BP1 10146 2 10 31
GSE46452 G3BP1 10146 0 27 32
GSE47630 G3BP1 10146 0 20 20
GSE54993 G3BP1 10146 9 1 60
GSE54994 G3BP1 10146 2 15 36
GSE60625 G3BP1 10146 0 0 11
GSE74703 G3BP1 10146 2 8 26
GSE74704 G3BP1 10146 1 7 12
TCGA G3BP1 10146 5 37 54

Total number of gains: 23; Total number of losses: 149; Total Number of normals: 316.  

 

Somatic mutations of G3BP1:

 

Generating mutation plots.

 

Highly correlated genes for G3BP1:

 

Showing top 20/1146 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
G3BP1CXCL160.751239303
G3BP1EME10.728592404
G3BP1RCC20.723548404
G3BP1AJUBA0.718282404
G3BP1SLC30A70.699979303
G3BP1CCDC180.694435303
G3BP1DCBLD10.691707403
G3BP1KIF140.686659707
G3BP1DPP30.686213606
G3BP1ANLN0.680695403
G3BP1ZBTB90.679623404
G3BP1UBE2T0.676684403
G3BP1CCNB10.670909807
G3BP1ARHGEF190.670136403
G3BP1TMPO0.668396505
G3BP1FIGNL10.66688403
G3BP1STARD100.665047303
G3BP1PIGW0.664363403
G3BP1CDCA20.664173403
G3BP1CDH30.662766705

For details and further investigation, click here