| Full name: major vault protein | Alias Symbol: LRP|VAULT1 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 9961 | HGNC ID: HGNC:7531 | Ensembl Gene: ENSG00000013364 | OMIM ID: 605088 |
| Drug and gene relationship at DGIdb | |||
Expression of MVP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MVP | 9961 | 202180_s_at | 0.1925 | 0.6405 | |
| GSE20347 | MVP | 9961 | 202180_s_at | -0.5263 | 0.0029 | |
| GSE23400 | MVP | 9961 | 202180_s_at | 0.1425 | 0.0463 | |
| GSE26886 | MVP | 9961 | 202180_s_at | 0.3119 | 0.1850 | |
| GSE29001 | MVP | 9961 | 202180_s_at | -0.0146 | 0.9666 | |
| GSE38129 | MVP | 9961 | 202180_s_at | -0.3436 | 0.0375 | |
| GSE45670 | MVP | 9961 | 202180_s_at | 0.5036 | 0.0045 | |
| GSE53622 | MVP | 9961 | 55022 | -0.2571 | 0.0058 | |
| GSE53624 | MVP | 9961 | 55022 | 0.0646 | 0.4150 | |
| GSE63941 | MVP | 9961 | 202180_s_at | -1.1939 | 0.1383 | |
| GSE77861 | MVP | 9961 | 202180_s_at | 0.1662 | 0.5963 | |
| GSE97050 | MVP | 9961 | A_33_P3294608 | 0.4169 | 0.2017 | |
| SRP007169 | MVP | 9961 | RNAseq | -0.2997 | 0.4517 | |
| SRP008496 | MVP | 9961 | RNAseq | -0.2420 | 0.3206 | |
| SRP064894 | MVP | 9961 | RNAseq | 0.7516 | 0.0062 | |
| SRP133303 | MVP | 9961 | RNAseq | 0.4641 | 0.0245 | |
| SRP159526 | MVP | 9961 | RNAseq | -0.5634 | 0.1831 | |
| SRP193095 | MVP | 9961 | RNAseq | -0.1726 | 0.4701 | |
| SRP219564 | MVP | 9961 | RNAseq | 0.1686 | 0.6550 | |
| TCGA | MVP | 9961 | RNAseq | -0.0890 | 0.1585 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MVP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MVP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MVP | 9961 | 5 | 5 | 20 | |
| GSE20123 | MVP | 9961 | 5 | 4 | 21 | |
| GSE43470 | MVP | 9961 | 3 | 3 | 37 | |
| GSE46452 | MVP | 9961 | 38 | 1 | 20 | |
| GSE47630 | MVP | 9961 | 11 | 7 | 22 | |
| GSE54993 | MVP | 9961 | 3 | 5 | 62 | |
| GSE54994 | MVP | 9961 | 5 | 9 | 39 | |
| GSE60625 | MVP | 9961 | 4 | 0 | 7 | |
| GSE74703 | MVP | 9961 | 3 | 2 | 31 | |
| GSE74704 | MVP | 9961 | 3 | 2 | 15 | |
| TCGA | MVP | 9961 | 20 | 11 | 65 |
Total number of gains: 100; Total number of losses: 49; Total Number of normals: 339.
Somatic mutations of MVP:
Generating mutation plots.
Highly correlated genes for MVP:
Showing top 20/413 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MVP | ATP6V0E1 | 0.80812 | 3 | 0 | 3 |
| MVP | LACTB | 0.793665 | 3 | 0 | 3 |
| MVP | CXCL16 | 0.784826 | 3 | 0 | 3 |
| MVP | TMEM17 | 0.764034 | 3 | 0 | 3 |
| MVP | GSPT1 | 0.760608 | 3 | 0 | 3 |
| MVP | GPN1 | 0.754551 | 3 | 0 | 3 |
| MVP | WDFY1 | 0.750969 | 3 | 0 | 3 |
| MVP | WIPF2 | 0.749751 | 3 | 0 | 3 |
| MVP | SLC30A7 | 0.734791 | 3 | 0 | 3 |
| MVP | USP40 | 0.732582 | 3 | 0 | 3 |
| MVP | CXXC5 | 0.732149 | 3 | 0 | 3 |
| MVP | XRCC4 | 0.73209 | 3 | 0 | 3 |
| MVP | TCF19 | 0.730098 | 3 | 0 | 3 |
| MVP | PEX14 | 0.727448 | 3 | 0 | 3 |
| MVP | ASB7 | 0.7197 | 4 | 0 | 4 |
| MVP | SMAD3 | 0.716027 | 3 | 0 | 3 |
| MVP | USF1 | 0.712539 | 3 | 0 | 3 |
| MVP | CENPT | 0.712032 | 3 | 0 | 3 |
| MVP | UHMK1 | 0.70953 | 3 | 0 | 3 |
| MVP | PLEKHA2 | 0.704937 | 4 | 0 | 3 |
For details and further investigation, click here
