| Full name: ALG2 alpha-1,3/1,6-mannosyltransferase | Alias Symbol: CDGIi|FLJ14511|hALPG2|NET38|CDG1I | ||
| Type: protein-coding gene | Cytoband: 9q22.33 | ||
| Entrez ID: 85365 | HGNC ID: HGNC:23159 | Ensembl Gene: ENSG00000119523 | OMIM ID: 607905 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ALG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALG2 | 85365 | 225621_at | 0.5035 | 0.1578 | |
| GSE26886 | ALG2 | 85365 | 225621_at | -0.0438 | 0.8623 | |
| GSE45670 | ALG2 | 85365 | 225621_at | 0.5835 | 0.0008 | |
| GSE53622 | ALG2 | 85365 | 26506 | 0.3150 | 0.0000 | |
| GSE53624 | ALG2 | 85365 | 26506 | 0.3975 | 0.0000 | |
| GSE63941 | ALG2 | 85365 | 225621_at | -0.1677 | 0.7603 | |
| GSE77861 | ALG2 | 85365 | 225621_at | 0.4675 | 0.0433 | |
| GSE97050 | ALG2 | 85365 | A_23_P146728 | 0.4214 | 0.2470 | |
| SRP007169 | ALG2 | 85365 | RNAseq | 0.3842 | 0.3438 | |
| SRP008496 | ALG2 | 85365 | RNAseq | 0.3194 | 0.0984 | |
| SRP064894 | ALG2 | 85365 | RNAseq | 0.3827 | 0.0070 | |
| SRP133303 | ALG2 | 85365 | RNAseq | 0.4206 | 0.0380 | |
| SRP159526 | ALG2 | 85365 | RNAseq | 0.2958 | 0.1747 | |
| SRP193095 | ALG2 | 85365 | RNAseq | 0.1165 | 0.4305 | |
| SRP219564 | ALG2 | 85365 | RNAseq | 0.3107 | 0.1456 | |
| TCGA | ALG2 | 85365 | RNAseq | -0.0385 | 0.4663 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALG2 | 85365 | 4 | 9 | 17 | |
| GSE20123 | ALG2 | 85365 | 4 | 8 | 18 | |
| GSE43470 | ALG2 | 85365 | 6 | 3 | 34 | |
| GSE46452 | ALG2 | 85365 | 6 | 13 | 40 | |
| GSE47630 | ALG2 | 85365 | 1 | 17 | 22 | |
| GSE54993 | ALG2 | 85365 | 3 | 3 | 64 | |
| GSE54994 | ALG2 | 85365 | 8 | 11 | 34 | |
| GSE60625 | ALG2 | 85365 | 0 | 0 | 11 | |
| GSE74703 | ALG2 | 85365 | 5 | 3 | 28 | |
| GSE74704 | ALG2 | 85365 | 2 | 5 | 13 | |
| TCGA | ALG2 | 85365 | 27 | 22 | 47 |
Total number of gains: 66; Total number of losses: 94; Total Number of normals: 328.
Somatic mutations of ALG2:
Generating mutation plots.
Highly correlated genes for ALG2:
Showing top 20/873 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALG2 | TOR1A | 0.807368 | 4 | 0 | 4 |
| ALG2 | CSTF3 | 0.782832 | 4 | 0 | 4 |
| ALG2 | MAP4K4 | 0.76252 | 3 | 0 | 3 |
| ALG2 | SP3 | 0.757541 | 3 | 0 | 3 |
| ALG2 | KLHL5 | 0.750705 | 3 | 0 | 3 |
| ALG2 | KTI12 | 0.748316 | 3 | 0 | 3 |
| ALG2 | CENPBD1 | 0.730949 | 3 | 0 | 3 |
| ALG2 | MTCH2 | 0.7276 | 3 | 0 | 3 |
| ALG2 | TMPO | 0.725482 | 3 | 0 | 3 |
| ALG2 | ITPR3 | 0.724883 | 5 | 0 | 5 |
| ALG2 | ETNK1 | 0.720816 | 3 | 0 | 3 |
| ALG2 | IRF9 | 0.71883 | 3 | 0 | 3 |
| ALG2 | LRP8 | 0.715798 | 3 | 0 | 3 |
| ALG2 | SPAST | 0.713982 | 3 | 0 | 3 |
| ALG2 | BORA | 0.710014 | 4 | 0 | 4 |
| ALG2 | FASTKD1 | 0.707999 | 4 | 0 | 4 |
| ALG2 | MCM3 | 0.707808 | 3 | 0 | 3 |
| ALG2 | TSPAN17 | 0.705795 | 4 | 0 | 3 |
| ALG2 | CYBA | 0.70429 | 4 | 0 | 4 |
| ALG2 | EML4 | 0.70382 | 4 | 0 | 3 |
For details and further investigation, click here
