| Full name: cytochrome c1 | Alias Symbol: UQCR4 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 1537 | HGNC ID: HGNC:2579 | Ensembl Gene: ENSG00000179091 | OMIM ID: 123980 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CYC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYC1 | 1537 | 201066_at | 0.5300 | 0.0357 | |
| GSE20347 | CYC1 | 1537 | 201066_at | 0.3490 | 0.0534 | |
| GSE23400 | CYC1 | 1537 | 201066_at | 0.3141 | 0.0004 | |
| GSE26886 | CYC1 | 1537 | 201066_at | -0.3708 | 0.2089 | |
| GSE29001 | CYC1 | 1537 | 201066_at | 0.2832 | 0.5721 | |
| GSE38129 | CYC1 | 1537 | 201066_at | 0.3234 | 0.0272 | |
| GSE45670 | CYC1 | 1537 | 201066_at | 0.0475 | 0.8639 | |
| GSE53622 | CYC1 | 1537 | 27224 | 0.0184 | 0.7998 | |
| GSE53624 | CYC1 | 1537 | 27224 | 0.3629 | 0.0000 | |
| GSE63941 | CYC1 | 1537 | 201066_at | 1.5018 | 0.0056 | |
| GSE77861 | CYC1 | 1537 | 201066_at | 0.1726 | 0.5613 | |
| GSE97050 | CYC1 | 1537 | A_23_P20980 | 0.3419 | 0.4320 | |
| SRP007169 | CYC1 | 1537 | RNAseq | -0.4392 | 0.1233 | |
| SRP008496 | CYC1 | 1537 | RNAseq | -0.5967 | 0.0001 | |
| SRP064894 | CYC1 | 1537 | RNAseq | 0.2410 | 0.3622 | |
| SRP133303 | CYC1 | 1537 | RNAseq | 0.1932 | 0.3396 | |
| SRP159526 | CYC1 | 1537 | RNAseq | 0.2648 | 0.4451 | |
| SRP193095 | CYC1 | 1537 | RNAseq | 0.0213 | 0.8941 | |
| SRP219564 | CYC1 | 1537 | RNAseq | 0.3006 | 0.5315 | |
| TCGA | CYC1 | 1537 | RNAseq | 0.0455 | 0.3868 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CYC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYC1 | 1537 | 17 | 1 | 12 | |
| GSE20123 | CYC1 | 1537 | 17 | 1 | 12 | |
| GSE43470 | CYC1 | 1537 | 16 | 2 | 25 | |
| GSE46452 | CYC1 | 1537 | 27 | 0 | 32 | |
| GSE47630 | CYC1 | 1537 | 23 | 1 | 16 | |
| GSE54993 | CYC1 | 1537 | 0 | 25 | 45 | |
| GSE54994 | CYC1 | 1537 | 39 | 1 | 13 | |
| GSE60625 | CYC1 | 1537 | 3 | 4 | 4 | |
| GSE74703 | CYC1 | 1537 | 14 | 1 | 21 | |
| GSE74704 | CYC1 | 1537 | 10 | 0 | 10 | |
| TCGA | CYC1 | 1537 | 63 | 2 | 31 |
Total number of gains: 229; Total number of losses: 38; Total Number of normals: 221.
Somatic mutations of CYC1:
Generating mutation plots.
Highly correlated genes for CYC1:
Showing top 20/375 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYC1 | RPL8 | 0.737957 | 11 | 0 | 11 |
| CYC1 | NDUFB9 | 0.67892 | 9 | 0 | 8 |
| CYC1 | HSD3B7 | 0.6711 | 3 | 0 | 3 |
| CYC1 | RECQL4 | 0.666708 | 4 | 0 | 3 |
| CYC1 | MRPS28 | 0.665664 | 9 | 0 | 7 |
| CYC1 | C8orf82 | 0.65939 | 5 | 0 | 4 |
| CYC1 | CMTM4 | 0.654599 | 4 | 0 | 4 |
| CYC1 | EXOSC4 | 0.65213 | 13 | 0 | 9 |
| CYC1 | TIGD5 | 0.644568 | 5 | 0 | 4 |
| CYC1 | MRPL15 | 0.641737 | 11 | 0 | 9 |
| CYC1 | SAPCD2 | 0.639076 | 5 | 0 | 4 |
| CYC1 | COX6C | 0.636016 | 11 | 0 | 8 |
| CYC1 | MAF1 | 0.63528 | 8 | 0 | 6 |
| CYC1 | VGLL4 | 0.629559 | 3 | 0 | 3 |
| CYC1 | ANP32A | 0.626466 | 3 | 0 | 3 |
| CYC1 | NUDCD1 | 0.62464 | 5 | 0 | 3 |
| CYC1 | ASAP1 | 0.623902 | 4 | 0 | 3 |
| CYC1 | PUF60 | 0.622714 | 12 | 0 | 9 |
| CYC1 | RPS18 | 0.620979 | 3 | 0 | 3 |
| CYC1 | MOB1A | 0.620714 | 5 | 0 | 4 |
For details and further investigation, click here
