RECQL4

 

Full name: RecQ like helicase 4 Alias Symbol: RecQ4
Type: protein-coding gene Cytoband: 8q24.3
Entrez ID: 9401 HGNC ID: HGNC:9949 Ensembl Gene: ENSG00000160957 OMIM ID: 603780
Drug and gene relationship at DGIdb

 

Expression of RECQL4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RECQL4 9401 1553015_a_at 1.0383 0.0446
GSE20347 RECQL4 9401 213520_at 0.5429 0.0001
GSE23400 RECQL4 9401 213520_at 0.5351 0.0000
GSE26886 RECQL4 9401 1553015_a_at 0.0657 0.8228
GSE29001 RECQL4 9401 213520_at 1.0739 0.0024
GSE38129 RECQL4 9401 213520_at 0.5823 0.0000
GSE45670 RECQL4 9401 1553015_a_at 0.1836 0.2370
GSE53622 RECQL4 9401 58401 0.8365 0.0000
GSE53624 RECQL4 9401 58401 1.2562 0.0000
GSE63941 RECQL4 9401 1553015_a_at 0.7108 0.0454
GSE77861 RECQL4 9401 1553015_a_at 0.2872 0.0936
GSE97050 RECQL4 9401 A_33_P3323847 0.9019 0.1702
SRP007169 RECQL4 9401 RNAseq 0.3772 0.3882
SRP008496 RECQL4 9401 RNAseq 0.9148 0.0032
SRP064894 RECQL4 9401 RNAseq 1.3020 0.0004
SRP133303 RECQL4 9401 RNAseq 0.6746 0.0765
SRP159526 RECQL4 9401 RNAseq 1.6542 0.0008
SRP193095 RECQL4 9401 RNAseq 0.9754 0.0000
SRP219564 RECQL4 9401 RNAseq 0.9989 0.2289
TCGA RECQL4 9401 RNAseq 1.0061 0.0000

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by RECQL4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RECQL4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RECQL4 9401 17 1 12
GSE20123 RECQL4 9401 17 1 12
GSE43470 RECQL4 9401 16 2 25
GSE46452 RECQL4 9401 28 0 31
GSE47630 RECQL4 9401 25 1 14
GSE54993 RECQL4 9401 0 25 45
GSE54994 RECQL4 9401 39 1 13
GSE60625 RECQL4 9401 3 4 4
GSE74703 RECQL4 9401 14 1 21
GSE74704 RECQL4 9401 10 0 10
TCGA RECQL4 9401 63 2 31

Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.  

 

Somatic mutations of RECQL4:

 

Generating mutation plots.

 

Highly correlated genes for RECQL4:

 

Showing top 20/641 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RECQL4GPR1800.733578303
RECQL4WRNIP10.729035303
RECQL4KIF18B0.72339810010
RECQL4RHPN20.714557504
RECQL4BOP10.713802404
RECQL4KIF21B0.708151303
RECQL4GNPNAT10.707627303
RECQL4TROAP0.69389811011
RECQL4GPRIN10.693295605
RECQL4TOP1MT0.690657707
RECQL4STAT40.678416303
RECQL4CRELD20.677338303
RECQL4E2F10.671561109
RECQL4ZMYND150.670543403
RECQL4CYC10.666708403
RECQL4MCM40.66627911010
RECQL4HSF10.6645041009
RECQL4ATG16L10.662344303
RECQL4SLC52A20.65697810010
RECQL4CEP1310.65506605

For details and further investigation, click here