| Full name: ribosomal protein L8 | Alias Symbol: L8 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 6132 | HGNC ID: HGNC:10368 | Ensembl Gene: ENSG00000161016 | OMIM ID: 604177 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RPL8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPL8 | 6132 | 200936_at | 0.3736 | 0.1144 | |
| GSE20347 | RPL8 | 6132 | 200936_at | 0.2483 | 0.0195 | |
| GSE23400 | RPL8 | 6132 | 200936_at | 0.2921 | 0.0002 | |
| GSE26886 | RPL8 | 6132 | 200936_at | -0.1528 | 0.4866 | |
| GSE29001 | RPL8 | 6132 | 200936_at | -0.0589 | 0.9218 | |
| GSE38129 | RPL8 | 6132 | 200936_at | 0.2803 | 0.0006 | |
| GSE45670 | RPL8 | 6132 | 200936_at | -0.0137 | 0.9314 | |
| GSE53622 | RPL8 | 6132 | 72059 | -0.5657 | 0.0000 | |
| GSE53624 | RPL8 | 6132 | 72059 | -0.3460 | 0.0000 | |
| GSE63941 | RPL8 | 6132 | 200936_at | 1.0827 | 0.0005 | |
| GSE77861 | RPL8 | 6132 | 200936_at | 0.1821 | 0.5065 | |
| GSE97050 | RPL8 | 6132 | A_23_P31654 | 0.0080 | 0.9808 | |
| SRP007169 | RPL8 | 6132 | RNAseq | -0.7415 | 0.0290 | |
| SRP008496 | RPL8 | 6132 | RNAseq | -0.5631 | 0.0024 | |
| SRP064894 | RPL8 | 6132 | RNAseq | 0.4052 | 0.2698 | |
| SRP133303 | RPL8 | 6132 | RNAseq | -0.0174 | 0.9095 | |
| SRP159526 | RPL8 | 6132 | RNAseq | -0.2474 | 0.2325 | |
| SRP193095 | RPL8 | 6132 | RNAseq | -0.4244 | 0.0138 | |
| SRP219564 | RPL8 | 6132 | RNAseq | 0.1091 | 0.7948 | |
| TCGA | RPL8 | 6132 | RNAseq | 0.1174 | 0.0206 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RPL8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPL8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPL8 | 6132 | 18 | 1 | 11 | |
| GSE20123 | RPL8 | 6132 | 18 | 1 | 11 | |
| GSE43470 | RPL8 | 6132 | 16 | 2 | 25 | |
| GSE46452 | RPL8 | 6132 | 28 | 0 | 31 | |
| GSE47630 | RPL8 | 6132 | 25 | 1 | 14 | |
| GSE54993 | RPL8 | 6132 | 0 | 25 | 45 | |
| GSE54994 | RPL8 | 6132 | 39 | 1 | 13 | |
| GSE60625 | RPL8 | 6132 | 3 | 4 | 4 | |
| GSE74703 | RPL8 | 6132 | 14 | 1 | 21 | |
| GSE74704 | RPL8 | 6132 | 11 | 0 | 9 | |
| TCGA | RPL8 | 6132 | 63 | 2 | 31 |
Total number of gains: 235; Total number of losses: 38; Total Number of normals: 215.
Somatic mutations of RPL8:
Generating mutation plots.
Highly correlated genes for RPL8:
Showing top 20/630 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPL8 | PFKP | 0.776068 | 3 | 0 | 3 |
| RPL8 | CDC5L | 0.76183 | 3 | 0 | 3 |
| RPL8 | PLCG1 | 0.754666 | 4 | 0 | 4 |
| RPL8 | PPP1R16A | 0.751369 | 5 | 0 | 5 |
| RPL8 | MRPS9 | 0.749412 | 3 | 0 | 3 |
| RPL8 | TP53RK | 0.747197 | 3 | 0 | 3 |
| RPL8 | CYC1 | 0.737957 | 11 | 0 | 11 |
| RPL8 | ZNF391 | 0.725277 | 4 | 0 | 4 |
| RPL8 | CLPTM1 | 0.724389 | 3 | 0 | 3 |
| RPL8 | KBTBD7 | 0.723349 | 3 | 0 | 3 |
| RPL8 | ACACA | 0.717299 | 3 | 0 | 3 |
| RPL8 | SPIRE2 | 0.715321 | 3 | 0 | 3 |
| RPL8 | NDUFS3 | 0.708391 | 4 | 0 | 3 |
| RPL8 | CMTM4 | 0.707584 | 4 | 0 | 3 |
| RPL8 | RRP15 | 0.70704 | 4 | 0 | 4 |
| RPL8 | EEF2 | 0.7046 | 4 | 0 | 3 |
| RPL8 | TUBGCP2 | 0.703799 | 4 | 0 | 4 |
| RPL8 | KIAA0586 | 0.702055 | 3 | 0 | 3 |
| RPL8 | MRPL9 | 0.701931 | 4 | 0 | 4 |
| RPL8 | ABCD4 | 0.701755 | 4 | 0 | 3 |
For details and further investigation, click here
