| Full name: cytoplasmic FMR1 interacting protein 1 | Alias Symbol: KIAA0068|P140SRA-1|SHYC | ||
| Type: protein-coding gene | Cytoband: 15q11.2 | ||
| Entrez ID: 23191 | HGNC ID: HGNC:13759 | Ensembl Gene: ENSG00000273749 | OMIM ID: 606322 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CYFIP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of CYFIP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYFIP1 | 23191 | 208923_at | -0.1844 | 0.7963 | |
| GSE20347 | CYFIP1 | 23191 | 208923_at | -0.4890 | 0.0002 | |
| GSE23400 | CYFIP1 | 23191 | 208923_at | -0.1368 | 0.0295 | |
| GSE26886 | CYFIP1 | 23191 | 208923_at | -0.4029 | 0.0106 | |
| GSE29001 | CYFIP1 | 23191 | 208923_at | -0.3979 | 0.1304 | |
| GSE38129 | CYFIP1 | 23191 | 208923_at | -0.2154 | 0.1507 | |
| GSE45670 | CYFIP1 | 23191 | 208923_at | -0.2366 | 0.0260 | |
| GSE53622 | CYFIP1 | 23191 | 39704 | -0.2977 | 0.0001 | |
| GSE53624 | CYFIP1 | 23191 | 39704 | -0.4162 | 0.0000 | |
| GSE63941 | CYFIP1 | 23191 | 208923_at | 0.1204 | 0.8179 | |
| GSE77861 | CYFIP1 | 23191 | 208923_at | -0.4278 | 0.0272 | |
| GSE97050 | CYFIP1 | 23191 | A_23_P140648 | -0.2085 | 0.4822 | |
| SRP007169 | CYFIP1 | 23191 | RNAseq | -0.2953 | 0.4429 | |
| SRP008496 | CYFIP1 | 23191 | RNAseq | -0.5289 | 0.0165 | |
| SRP064894 | CYFIP1 | 23191 | RNAseq | -0.2393 | 0.0627 | |
| SRP133303 | CYFIP1 | 23191 | RNAseq | -0.2472 | 0.0878 | |
| SRP159526 | CYFIP1 | 23191 | RNAseq | -0.4387 | 0.1962 | |
| SRP193095 | CYFIP1 | 23191 | RNAseq | -0.3152 | 0.0011 | |
| SRP219564 | CYFIP1 | 23191 | RNAseq | -0.4198 | 0.0665 | |
| TCGA | CYFIP1 | 23191 | RNAseq | 0.0153 | 0.7230 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYFIP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYFIP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYFIP1 | 23191 | 4 | 4 | 22 | |
| GSE20123 | CYFIP1 | 23191 | 3 | 4 | 23 | |
| GSE43470 | CYFIP1 | 23191 | 2 | 5 | 36 | |
| GSE46452 | CYFIP1 | 23191 | 3 | 7 | 49 | |
| GSE47630 | CYFIP1 | 23191 | 8 | 11 | 21 | |
| GSE54993 | CYFIP1 | 23191 | 4 | 6 | 60 | |
| GSE54994 | CYFIP1 | 23191 | 6 | 6 | 41 | |
| GSE60625 | CYFIP1 | 23191 | 4 | 3 | 4 | |
| GSE74703 | CYFIP1 | 23191 | 2 | 3 | 31 | |
| GSE74704 | CYFIP1 | 23191 | 2 | 4 | 14 | |
| TCGA | CYFIP1 | 23191 | 18 | 19 | 59 |
Total number of gains: 56; Total number of losses: 72; Total Number of normals: 360.
Somatic mutations of CYFIP1:
Generating mutation plots.
Highly correlated genes for CYFIP1:
Showing top 20/1169 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYFIP1 | DRAM2 | 0.738809 | 3 | 0 | 3 |
| CYFIP1 | SNX17 | 0.731477 | 5 | 0 | 5 |
| CYFIP1 | ALDOC | 0.730839 | 4 | 0 | 4 |
| CYFIP1 | ANKRD13C | 0.728724 | 3 | 0 | 3 |
| CYFIP1 | SH3BP5 | 0.727828 | 3 | 0 | 3 |
| CYFIP1 | ESYT2 | 0.720724 | 3 | 0 | 3 |
| CYFIP1 | ZNF564 | 0.718611 | 3 | 0 | 3 |
| CYFIP1 | TBC1D20 | 0.716491 | 3 | 0 | 3 |
| CYFIP1 | CCIN | 0.705876 | 4 | 0 | 4 |
| CYFIP1 | UBQLN1 | 0.705548 | 3 | 0 | 3 |
| CYFIP1 | MFAP1 | 0.702902 | 7 | 0 | 7 |
| CYFIP1 | TSPYL4 | 0.701005 | 4 | 0 | 4 |
| CYFIP1 | PUSL1 | 0.699976 | 3 | 0 | 3 |
| CYFIP1 | STOML2 | 0.699598 | 4 | 0 | 4 |
| CYFIP1 | CA5B | 0.696195 | 3 | 0 | 3 |
| CYFIP1 | DNAJB12 | 0.69513 | 3 | 0 | 3 |
| CYFIP1 | COPZ1 | 0.690151 | 6 | 0 | 4 |
| CYFIP1 | PEX2 | 0.685724 | 4 | 0 | 3 |
| CYFIP1 | IREB2 | 0.684505 | 6 | 0 | 5 |
| CYFIP1 | GFPT1 | 0.680412 | 5 | 0 | 4 |
For details and further investigation, click here
