| Full name: SH3 domain binding protein 5 | Alias Symbol: Sab | ||
| Type: protein-coding gene | Cytoband: 3p25.1 | ||
| Entrez ID: 9467 | HGNC ID: HGNC:10827 | Ensembl Gene: ENSG00000131370 | OMIM ID: 605612 |
| Drug and gene relationship at DGIdb | |||
Expression of SH3BP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH3BP5 | 9467 | 201811_x_at | -0.8709 | 0.2749 | |
| GSE20347 | SH3BP5 | 9467 | 201811_x_at | -0.7496 | 0.0000 | |
| GSE23400 | SH3BP5 | 9467 | 201811_x_at | -0.4874 | 0.0001 | |
| GSE26886 | SH3BP5 | 9467 | 201811_x_at | -0.3387 | 0.2557 | |
| GSE29001 | SH3BP5 | 9467 | 201811_x_at | -0.9547 | 0.0079 | |
| GSE38129 | SH3BP5 | 9467 | 201811_x_at | -0.7885 | 0.0000 | |
| GSE45670 | SH3BP5 | 9467 | 201811_x_at | -1.3243 | 0.0000 | |
| GSE63941 | SH3BP5 | 9467 | 201811_x_at | -1.4286 | 0.0250 | |
| GSE77861 | SH3BP5 | 9467 | 201811_x_at | -0.7358 | 0.0767 | |
| GSE97050 | SH3BP5 | 9467 | A_24_P148750 | -0.0403 | 0.8837 | |
| SRP007169 | SH3BP5 | 9467 | RNAseq | -0.8400 | 0.1206 | |
| SRP008496 | SH3BP5 | 9467 | RNAseq | -0.5426 | 0.1288 | |
| SRP064894 | SH3BP5 | 9467 | RNAseq | -0.2183 | 0.5891 | |
| SRP133303 | SH3BP5 | 9467 | RNAseq | -0.7107 | 0.0103 | |
| SRP159526 | SH3BP5 | 9467 | RNAseq | -0.5646 | 0.0161 | |
| SRP193095 | SH3BP5 | 9467 | RNAseq | -0.4563 | 0.0068 | |
| SRP219564 | SH3BP5 | 9467 | RNAseq | 0.6188 | 0.0468 | |
| TCGA | SH3BP5 | 9467 | RNAseq | -0.3298 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SH3BP5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SH3BP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH3BP5 | 9467 | 2 | 18 | 10 | |
| GSE20123 | SH3BP5 | 9467 | 2 | 18 | 10 | |
| GSE43470 | SH3BP5 | 9467 | 0 | 21 | 22 | |
| GSE46452 | SH3BP5 | 9467 | 2 | 17 | 40 | |
| GSE47630 | SH3BP5 | 9467 | 2 | 23 | 15 | |
| GSE54993 | SH3BP5 | 9467 | 6 | 1 | 63 | |
| GSE54994 | SH3BP5 | 9467 | 1 | 32 | 20 | |
| GSE60625 | SH3BP5 | 9467 | 5 | 0 | 6 | |
| GSE74703 | SH3BP5 | 9467 | 0 | 17 | 19 | |
| GSE74704 | SH3BP5 | 9467 | 1 | 12 | 7 | |
| TCGA | SH3BP5 | 9467 | 2 | 68 | 26 |
Total number of gains: 23; Total number of losses: 227; Total Number of normals: 238.
Somatic mutations of SH3BP5:
Generating mutation plots.
Highly correlated genes for SH3BP5:
Showing top 20/986 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH3BP5 | GIMAP7 | 0.824508 | 3 | 0 | 3 |
| SH3BP5 | GIMAP8 | 0.797755 | 3 | 0 | 3 |
| SH3BP5 | GBGT1 | 0.790161 | 3 | 0 | 3 |
| SH3BP5 | ECSCR | 0.779105 | 3 | 0 | 3 |
| SH3BP5 | GNGT2 | 0.772777 | 3 | 0 | 3 |
| SH3BP5 | EBF1 | 0.75384 | 4 | 0 | 4 |
| SH3BP5 | DNAJB9 | 0.753412 | 3 | 0 | 3 |
| SH3BP5 | RAB37 | 0.745115 | 3 | 0 | 3 |
| SH3BP5 | ZNF829 | 0.743231 | 3 | 0 | 3 |
| SH3BP5 | CYFIP1 | 0.727828 | 3 | 0 | 3 |
| SH3BP5 | GIMAP1 | 0.727363 | 3 | 0 | 3 |
| SH3BP5 | CLTB | 0.726766 | 3 | 0 | 3 |
| SH3BP5 | ARHGAP31 | 0.726546 | 4 | 0 | 3 |
| SH3BP5 | CLDND2 | 0.72624 | 3 | 0 | 3 |
| SH3BP5 | ATP6V1D | 0.723049 | 3 | 0 | 3 |
| SH3BP5 | LRRN4CL | 0.722646 | 4 | 0 | 4 |
| SH3BP5 | EPDR1 | 0.719393 | 3 | 0 | 3 |
| SH3BP5 | ZBTB5 | 0.719217 | 5 | 0 | 4 |
| SH3BP5 | COMMD1 | 0.717702 | 3 | 0 | 3 |
| SH3BP5 | PDE7B | 0.717373 | 4 | 0 | 4 |
For details and further investigation, click here
