GFPT1

 

Full name: glutamine--fructose-6-phosphate transaminase 1 Alias Symbol: GFAT|GFA|GFAT1
Type: protein-coding gene Cytoband: 2p13.3
Entrez ID: 2673 HGNC ID: HGNC:4241 Ensembl Gene: ENSG00000198380 OMIM ID: 138292
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of GFPT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GFPT1 2673 202722_s_at -0.0479 0.9564
GSE20347 GFPT1 2673 202722_s_at -0.1376 0.3374
GSE23400 GFPT1 2673 202722_s_at 0.1717 0.0887
GSE26886 GFPT1 2673 202722_s_at -0.6938 0.0022
GSE29001 GFPT1 2673 202722_s_at -0.3219 0.3995
GSE38129 GFPT1 2673 202722_s_at 0.1010 0.5382
GSE45670 GFPT1 2673 202722_s_at 0.2750 0.2037
GSE53622 GFPT1 2673 5736 0.0532 0.5632
GSE53624 GFPT1 2673 5736 0.0037 0.9722
GSE63941 GFPT1 2673 202722_s_at -1.0478 0.0990
GSE77861 GFPT1 2673 202722_s_at -0.2636 0.2412
GSE97050 GFPT1 2673 A_33_P3243153 0.1445 0.6763
SRP007169 GFPT1 2673 RNAseq 0.6755 0.1597
SRP008496 GFPT1 2673 RNAseq 0.6983 0.0051
SRP064894 GFPT1 2673 RNAseq -0.0054 0.9799
SRP133303 GFPT1 2673 RNAseq 0.4674 0.0860
SRP159526 GFPT1 2673 RNAseq 0.3026 0.1100
SRP193095 GFPT1 2673 RNAseq -0.2902 0.1827
SRP219564 GFPT1 2673 RNAseq 0.3422 0.3004
TCGA GFPT1 2673 RNAseq -0.2410 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GFPT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GFPT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GFPT1 2673 11 0 19
GSE20123 GFPT1 2673 11 0 19
GSE43470 GFPT1 2673 5 0 38
GSE46452 GFPT1 2673 2 3 54
GSE47630 GFPT1 2673 7 0 33
GSE54993 GFPT1 2673 0 6 64
GSE54994 GFPT1 2673 12 0 41
GSE60625 GFPT1 2673 0 3 8
GSE74703 GFPT1 2673 5 0 31
GSE74704 GFPT1 2673 9 0 11
TCGA GFPT1 2673 36 2 58

Total number of gains: 98; Total number of losses: 14; Total Number of normals: 376.  

 

Somatic mutations of GFPT1:

 

Generating mutation plots.

 

Highly correlated genes for GFPT1:

 

Showing top 20/518 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GFPT1AQR0.792238303
GFPT1LRBA0.760417404
GFPT1ST3GAL60.756495303
GFPT1CXXC50.751211303
GFPT1IMPACT0.730101303
GFPT1TRIM60.710825404
GFPT1TMED100.708704404
GFPT1TET20.706765404
GFPT1UBQLN10.706016303
GFPT1SVIP0.705903303
GFPT1HIBCH0.704873303
GFPT1KRCC10.703229303
GFPT1UBE2W0.703175404
GFPT1MUC40.694966303
GFPT1ZBTB8OS0.694508303
GFPT1DCAF120.692965303
GFPT1VDAC30.690562303
GFPT1CGGBP10.690258505
GFPT1TBC1D200.690155505
GFPT1ARRDC30.689568303

For details and further investigation, click here