| Full name: cytochrome P450 family 2 subfamily B member 6 | Alias Symbol: CPB6|CYPIIB6 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 1555 | HGNC ID: HGNC:2615 | Ensembl Gene: ENSG00000197408 | OMIM ID: 123930 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP2B6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP2B6 | 1555 | 206755_at | -0.1064 | 0.5165 | |
| GSE20347 | CYP2B6 | 1555 | 206755_at | 0.0855 | 0.2186 | |
| GSE23400 | CYP2B6 | 1555 | 206755_at | 0.0201 | 0.4737 | |
| GSE26886 | CYP2B6 | 1555 | 206755_at | -0.2765 | 0.0804 | |
| GSE29001 | CYP2B6 | 1555 | 206755_at | 0.0222 | 0.9097 | |
| GSE38129 | CYP2B6 | 1555 | 206755_at | 0.0513 | 0.5281 | |
| GSE45670 | CYP2B6 | 1555 | 206755_at | 0.0543 | 0.6166 | |
| GSE53622 | CYP2B6 | 1555 | 48824 | 0.8179 | 0.0000 | |
| GSE53624 | CYP2B6 | 1555 | 48824 | 0.4649 | 0.0000 | |
| GSE63941 | CYP2B6 | 1555 | 206755_at | -0.4521 | 0.0215 | |
| GSE77861 | CYP2B6 | 1555 | 206755_at | -0.0865 | 0.5036 | |
| GSE97050 | CYP2B6 | 1555 | A_23_P208373 | 0.3173 | 0.1868 | |
| SRP133303 | CYP2B6 | 1555 | RNAseq | -0.1594 | 0.4705 | |
| SRP193095 | CYP2B6 | 1555 | RNAseq | -0.3350 | 0.1339 | |
| TCGA | CYP2B6 | 1555 | RNAseq | 0.1944 | 0.8813 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYP2B6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP2B6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP2B6 | 1555 | 4 | 5 | 21 | |
| GSE20123 | CYP2B6 | 1555 | 4 | 4 | 22 | |
| GSE43470 | CYP2B6 | 1555 | 3 | 11 | 29 | |
| GSE46452 | CYP2B6 | 1555 | 48 | 1 | 10 | |
| GSE47630 | CYP2B6 | 1555 | 9 | 5 | 26 | |
| GSE54993 | CYP2B6 | 1555 | 17 | 4 | 49 | |
| GSE54994 | CYP2B6 | 1555 | 7 | 11 | 35 | |
| GSE60625 | CYP2B6 | 1555 | 9 | 0 | 2 | |
| GSE74703 | CYP2B6 | 1555 | 3 | 7 | 26 | |
| GSE74704 | CYP2B6 | 1555 | 4 | 2 | 14 | |
| TCGA | CYP2B6 | 1555 | 14 | 16 | 66 |
Total number of gains: 122; Total number of losses: 66; Total Number of normals: 300.
Somatic mutations of CYP2B6:
Generating mutation plots.
Highly correlated genes for CYP2B6:
Showing top 20/293 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP2B6 | ALG11 | 0.821219 | 3 | 0 | 3 |
| CYP2B6 | OR2AT4 | 0.735777 | 3 | 0 | 3 |
| CYP2B6 | NCDN | 0.73148 | 3 | 0 | 3 |
| CYP2B6 | SLC26A5 | 0.730319 | 3 | 0 | 3 |
| CYP2B6 | NHLH2 | 0.714394 | 3 | 0 | 3 |
| CYP2B6 | FLVCR2 | 0.70717 | 3 | 0 | 3 |
| CYP2B6 | AMBRA1 | 0.703516 | 3 | 0 | 3 |
| CYP2B6 | PIM2 | 0.694344 | 3 | 0 | 3 |
| CYP2B6 | FYTTD1 | 0.689538 | 3 | 0 | 3 |
| CYP2B6 | TSSK6 | 0.683061 | 3 | 0 | 3 |
| CYP2B6 | DSCR10 | 0.68271 | 3 | 0 | 3 |
| CYP2B6 | TCAP | 0.680726 | 3 | 0 | 3 |
| CYP2B6 | LMF2 | 0.679152 | 3 | 0 | 3 |
| CYP2B6 | SYTL4 | 0.675672 | 3 | 0 | 3 |
| CYP2B6 | PSKH1 | 0.674801 | 3 | 0 | 3 |
| CYP2B6 | HHLA1 | 0.667232 | 5 | 0 | 5 |
| CYP2B6 | LGI2 | 0.666968 | 3 | 0 | 3 |
| CYP2B6 | ZNF546 | 0.664649 | 4 | 0 | 3 |
| CYP2B6 | ZNF248 | 0.659141 | 5 | 0 | 4 |
| CYP2B6 | DMBT1 | 0.656786 | 4 | 0 | 3 |
For details and further investigation, click here
