GNAI3

 

Full name: G protein subunit alpha i3 Alias Symbol: 87U6
Type: protein-coding gene Cytoband: 1p13.3
Entrez ID: 2773 HGNC ID: HGNC:4387 Ensembl Gene: ENSG00000065135 OMIM ID: 139370
Drug and gene relationship at DGIdb

 

GNAI3 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04360Axon guidance
hsa04540Gap junction
hsa04611Platelet activation
hsa04670Leukocyte transendothelial migration
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04924Renin secretion
hsa04971Gastric acid secretion
hsa05012Parkinson's disease
hsa05030Cocaine addiction
hsa05032Morphine addiction
hsa05034Alcoholism
hsa05133Pertussis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis

 

Expression of GNAI3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNAI3 2773 201180_s_at -0.5122 0.2858
GSE20347 GNAI3 2773 201180_s_at -1.0280 0.0000
GSE23400 GNAI3 2773 201180_s_at -0.3342 0.0000
GSE26886 GNAI3 2773 201180_s_at -1.3253 0.0000
GSE29001 GNAI3 2773 201180_s_at -0.3574 0.0571
GSE38129 GNAI3 2773 201180_s_at -0.6021 0.0001
GSE45670 GNAI3 2773 201180_s_at -0.2420 0.0733
GSE53622 GNAI3 2773 25268 -0.7990 0.0000
GSE53624 GNAI3 2773 25268 -0.8368 0.0000
GSE63941 GNAI3 2773 201180_s_at -0.2945 0.5215
GSE77861 GNAI3 2773 201180_s_at -0.7411 0.0026
GSE97050 GNAI3 2773 A_33_P3419334 -0.2463 0.4576
SRP007169 GNAI3 2773 RNAseq -1.2586 0.0022
SRP008496 GNAI3 2773 RNAseq -1.3658 0.0000
SRP064894 GNAI3 2773 RNAseq -0.5316 0.0061
SRP133303 GNAI3 2773 RNAseq -0.3366 0.0307
SRP159526 GNAI3 2773 RNAseq -1.2079 0.0000
SRP193095 GNAI3 2773 RNAseq -0.8615 0.0000
SRP219564 GNAI3 2773 RNAseq -0.6603 0.1746
TCGA GNAI3 2773 RNAseq 0.1349 0.0037

Upregulated datasets: 0; Downregulated datasets: 5.  

 

Survival by GNAI3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNAI3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNAI3 2773 0 12 18
GSE20123 GNAI3 2773 0 11 19
GSE43470 GNAI3 2773 0 9 34
GSE46452 GNAI3 2773 2 1 56
GSE47630 GNAI3 2773 9 5 26
GSE54993 GNAI3 2773 0 1 69
GSE54994 GNAI3 2773 7 4 42
GSE60625 GNAI3 2773 0 0 11
GSE74703 GNAI3 2773 0 7 29
GSE74704 GNAI3 2773 0 7 13
TCGA GNAI3 2773 9 26 61

Total number of gains: 27; Total number of losses: 83; Total Number of normals: 378.  

 

Somatic mutations of GNAI3:

 

Generating mutation plots.

 

Highly correlated genes for GNAI3:

 

Showing top 20/1513 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNAI3CYP2C190.77285303
GNAI3PDCD6IP0.77024711011
GNAI3CTTNBP2NL0.762429908
GNAI3FOPNL0.749853303
GNAI3RNF1410.74702811011
GNAI3TAB30.746583707
GNAI3IKZF50.74646303
GNAI3RTCA0.74414811011
GNAI3FBXL160.735869606
GNAI3SOCS60.734486909
GNAI3APOB0.733404
GNAI3KCNK60.729151505
GNAI3ESYT20.727782504
GNAI3BRK10.727197707
GNAI3FRMD4B0.72620511011
GNAI3S100A160.722231606
GNAI3ANKRD310.720131505
GNAI3SNX330.718554504
GNAI3GSKIP0.718426606
GNAI3CYP4F220.718166303

For details and further investigation, click here