| Full name: CWC25 spliceosome associated protein homolog | Alias Symbol: FLJ20291 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 54883 | HGNC ID: HGNC:25989 | Ensembl Gene: ENSG00000273559 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CWC25:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CWC25 | 54883 | 218655_s_at | -0.1401 | 0.6730 | |
| GSE20347 | CWC25 | 54883 | 218655_s_at | 0.1255 | 0.3479 | |
| GSE23400 | CWC25 | 54883 | 218655_s_at | 0.0332 | 0.3346 | |
| GSE26886 | CWC25 | 54883 | 218655_s_at | -1.0896 | 0.0000 | |
| GSE29001 | CWC25 | 54883 | 218655_s_at | 0.0524 | 0.8113 | |
| GSE38129 | CWC25 | 54883 | 218655_s_at | 0.0493 | 0.5884 | |
| GSE45670 | CWC25 | 54883 | 218655_s_at | 0.2661 | 0.1796 | |
| GSE53622 | CWC25 | 54883 | 50368 | 0.2401 | 0.0001 | |
| GSE53624 | CWC25 | 54883 | 63466 | -0.0407 | 0.5391 | |
| GSE63941 | CWC25 | 54883 | 218655_s_at | -0.1337 | 0.6129 | |
| GSE77861 | CWC25 | 54883 | 218655_s_at | -0.0144 | 0.9404 | |
| GSE97050 | CWC25 | 54883 | A_24_P48318 | -0.0543 | 0.8845 | |
| SRP007169 | CWC25 | 54883 | RNAseq | 0.6704 | 0.1770 | |
| SRP008496 | CWC25 | 54883 | RNAseq | 0.5830 | 0.0834 | |
| SRP064894 | CWC25 | 54883 | RNAseq | 0.0281 | 0.8154 | |
| SRP133303 | CWC25 | 54883 | RNAseq | 0.0548 | 0.6605 | |
| SRP159526 | CWC25 | 54883 | RNAseq | -0.2289 | 0.3660 | |
| SRP193095 | CWC25 | 54883 | RNAseq | 0.0408 | 0.7114 | |
| SRP219564 | CWC25 | 54883 | RNAseq | -0.3898 | 0.1192 | |
| TCGA | CWC25 | 54883 | RNAseq | -0.0540 | 0.3270 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CWC25 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CWC25:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CWC25 | 54883 | 7 | 1 | 22 | |
| GSE20123 | CWC25 | 54883 | 7 | 1 | 22 | |
| GSE43470 | CWC25 | 54883 | 1 | 1 | 41 | |
| GSE46452 | CWC25 | 54883 | 34 | 0 | 25 | |
| GSE47630 | CWC25 | 54883 | 8 | 1 | 31 | |
| GSE54993 | CWC25 | 54883 | 3 | 4 | 63 | |
| GSE54994 | CWC25 | 54883 | 8 | 5 | 40 | |
| GSE60625 | CWC25 | 54883 | 4 | 0 | 7 | |
| GSE74703 | CWC25 | 54883 | 1 | 0 | 35 | |
| GSE74704 | CWC25 | 54883 | 4 | 1 | 15 | |
| TCGA | CWC25 | 54883 | 19 | 8 | 69 |
Total number of gains: 96; Total number of losses: 22; Total Number of normals: 370.
Somatic mutations of CWC25:
Generating mutation plots.
Highly correlated genes for CWC25:
Showing top 20/144 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CWC25 | ZCCHC9 | 0.762686 | 3 | 0 | 3 |
| CWC25 | PHKB | 0.759441 | 3 | 0 | 3 |
| CWC25 | NUFIP2 | 0.756725 | 3 | 0 | 3 |
| CWC25 | PRKAB1 | 0.752884 | 3 | 0 | 3 |
| CWC25 | PPM1B | 0.752859 | 3 | 0 | 3 |
| CWC25 | LARP4 | 0.752413 | 3 | 0 | 3 |
| CWC25 | SERTAD2 | 0.742205 | 3 | 0 | 3 |
| CWC25 | VPS25 | 0.741028 | 3 | 0 | 3 |
| CWC25 | CYP2C19 | 0.730854 | 3 | 0 | 3 |
| CWC25 | CISD3 | 0.717826 | 3 | 0 | 3 |
| CWC25 | RANBP10 | 0.714684 | 3 | 0 | 3 |
| CWC25 | MED1 | 0.713919 | 4 | 0 | 4 |
| CWC25 | ACADVL | 0.713883 | 3 | 0 | 3 |
| CWC25 | EPC1 | 0.70532 | 3 | 0 | 3 |
| CWC25 | PAIP2 | 0.70256 | 3 | 0 | 3 |
| CWC25 | NDUFS2 | 0.70228 | 3 | 0 | 3 |
| CWC25 | KRAS | 0.698776 | 3 | 0 | 3 |
| CWC25 | CHMP5 | 0.695163 | 3 | 0 | 3 |
| CWC25 | USP54 | 0.694636 | 3 | 0 | 3 |
| CWC25 | ARFGAP2 | 0.691582 | 3 | 0 | 3 |
For details and further investigation, click here
