| Full name: carboxylesterase 2 | Alias Symbol: CE-2|iCE|CES2A1 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 8824 | HGNC ID: HGNC:1864 | Ensembl Gene: ENSG00000172831 | OMIM ID: 605278 |
| Drug and gene relationship at DGIdb | |||
Expression of CES2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CES2 | 8824 | 209667_at | -1.9184 | 0.0559 | |
| GSE20347 | CES2 | 8824 | 213509_x_at | -1.7563 | 0.0000 | |
| GSE23400 | CES2 | 8824 | 213509_x_at | -1.2515 | 0.0000 | |
| GSE26886 | CES2 | 8824 | 209667_at | -1.9873 | 0.0000 | |
| GSE29001 | CES2 | 8824 | 213509_x_at | -2.2977 | 0.0000 | |
| GSE38129 | CES2 | 8824 | 209667_at | -1.6613 | 0.0000 | |
| GSE45670 | CES2 | 8824 | 209667_at | -0.9780 | 0.0062 | |
| GSE63941 | CES2 | 8824 | 209667_at | -0.3235 | 0.5745 | |
| GSE77861 | CES2 | 8824 | 209667_at | -1.4699 | 0.0102 | |
| GSE97050 | CES2 | 8824 | A_33_P3350393 | -0.5895 | 0.1074 | |
| SRP007169 | CES2 | 8824 | RNAseq | -3.5562 | 0.0000 | |
| SRP008496 | CES2 | 8824 | RNAseq | -3.9117 | 0.0000 | |
| SRP064894 | CES2 | 8824 | RNAseq | -2.3977 | 0.0000 | |
| SRP133303 | CES2 | 8824 | RNAseq | -2.2094 | 0.0000 | |
| SRP159526 | CES2 | 8824 | RNAseq | -2.1762 | 0.0000 | |
| SRP193095 | CES2 | 8824 | RNAseq | -2.4789 | 0.0000 | |
| SRP219564 | CES2 | 8824 | RNAseq | -1.9081 | 0.0038 | |
| TCGA | CES2 | 8824 | RNAseq | -0.0659 | 0.4672 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by CES2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CES2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CES2 | 8824 | 8 | 2 | 20 | |
| GSE20123 | CES2 | 8824 | 8 | 2 | 20 | |
| GSE43470 | CES2 | 8824 | 1 | 8 | 34 | |
| GSE46452 | CES2 | 8824 | 38 | 1 | 20 | |
| GSE47630 | CES2 | 8824 | 10 | 8 | 22 | |
| GSE54993 | CES2 | 8824 | 2 | 4 | 64 | |
| GSE54994 | CES2 | 8824 | 8 | 10 | 35 | |
| GSE60625 | CES2 | 8824 | 4 | 0 | 7 | |
| GSE74703 | CES2 | 8824 | 1 | 5 | 30 | |
| GSE74704 | CES2 | 8824 | 5 | 1 | 14 | |
| TCGA | CES2 | 8824 | 31 | 11 | 54 |
Total number of gains: 116; Total number of losses: 52; Total Number of normals: 320.
Somatic mutations of CES2:
Generating mutation plots.
Highly correlated genes for CES2:
Showing top 20/1226 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CES2 | CYSRT1 | 0.896739 | 4 | 0 | 4 |
| CES2 | GDPD3 | 0.884924 | 9 | 0 | 9 |
| CES2 | CAPN14 | 0.859904 | 4 | 0 | 4 |
| CES2 | EPS8L2 | 0.858351 | 9 | 0 | 9 |
| CES2 | ENDOU | 0.852325 | 9 | 0 | 9 |
| CES2 | SFTA2 | 0.85058 | 4 | 0 | 4 |
| CES2 | VSIG10L | 0.849714 | 5 | 0 | 5 |
| CES2 | RAB11A | 0.847605 | 8 | 0 | 8 |
| CES2 | RAET1E | 0.847411 | 5 | 0 | 5 |
| CES2 | TMPRSS11E | 0.843464 | 9 | 0 | 9 |
| CES2 | SLURP1 | 0.839733 | 10 | 0 | 9 |
| CES2 | MXD1 | 0.838223 | 9 | 0 | 9 |
| CES2 | CWH43 | 0.836247 | 8 | 0 | 8 |
| CES2 | ECM1 | 0.835288 | 10 | 0 | 9 |
| CES2 | PDCD6IP | 0.834135 | 8 | 0 | 8 |
| CES2 | CEACAM5 | 0.828325 | 9 | 0 | 9 |
| CES2 | SH3GL1 | 0.827317 | 8 | 0 | 8 |
| CES2 | PPL | 0.826509 | 10 | 0 | 10 |
| CES2 | SCEL | 0.825954 | 10 | 0 | 9 |
| CES2 | EMP1 | 0.825355 | 9 | 0 | 9 |
For details and further investigation, click here
