| Full name: cytochrome P450 family 4 subfamily B member 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p33 | ||
| Entrez ID: 1580 | HGNC ID: HGNC:2644 | Ensembl Gene: ENSG00000142973 | OMIM ID: 124075 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP4B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP4B1 | 1580 | 210096_at | -4.0149 | 0.0283 | |
| GSE20347 | CYP4B1 | 1580 | 210096_at | -3.9651 | 0.0000 | |
| GSE23400 | CYP4B1 | 1580 | 210096_at | -2.0132 | 0.0000 | |
| GSE26886 | CYP4B1 | 1580 | 210096_at | -5.4167 | 0.0000 | |
| GSE29001 | CYP4B1 | 1580 | 210096_at | -4.4597 | 0.0000 | |
| GSE38129 | CYP4B1 | 1580 | 210096_at | -3.4612 | 0.0000 | |
| GSE45670 | CYP4B1 | 1580 | 210096_at | -2.0484 | 0.0212 | |
| GSE53622 | CYP4B1 | 1580 | 161120 | -4.5226 | 0.0000 | |
| GSE53624 | CYP4B1 | 1580 | 161120 | -4.8200 | 0.0000 | |
| GSE63941 | CYP4B1 | 1580 | 1555497_a_at | 0.7245 | 0.3742 | |
| GSE77861 | CYP4B1 | 1580 | 210096_at | -3.9583 | 0.0002 | |
| GSE97050 | CYP4B1 | 1580 | A_23_P114713 | -1.7453 | 0.0530 | |
| SRP007169 | CYP4B1 | 1580 | RNAseq | -10.0914 | 0.0000 | |
| SRP008496 | CYP4B1 | 1580 | RNAseq | -6.7064 | 0.0000 | |
| SRP064894 | CYP4B1 | 1580 | RNAseq | -4.0798 | 0.0000 | |
| SRP133303 | CYP4B1 | 1580 | RNAseq | -4.2048 | 0.0000 | |
| SRP159526 | CYP4B1 | 1580 | RNAseq | -4.9731 | 0.0000 | |
| SRP219564 | CYP4B1 | 1580 | RNAseq | -2.2844 | 0.0223 | |
| TCGA | CYP4B1 | 1580 | RNAseq | -1.3835 | 0.0481 |
Upregulated datasets: 0; Downregulated datasets: 17.
Survival by CYP4B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP4B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP4B1 | 1580 | 4 | 3 | 23 | |
| GSE20123 | CYP4B1 | 1580 | 4 | 2 | 24 | |
| GSE43470 | CYP4B1 | 1580 | 5 | 1 | 37 | |
| GSE46452 | CYP4B1 | 1580 | 2 | 1 | 56 | |
| GSE47630 | CYP4B1 | 1580 | 8 | 4 | 28 | |
| GSE54993 | CYP4B1 | 1580 | 0 | 1 | 69 | |
| GSE54994 | CYP4B1 | 1580 | 11 | 2 | 40 | |
| GSE60625 | CYP4B1 | 1580 | 0 | 0 | 11 | |
| GSE74703 | CYP4B1 | 1580 | 4 | 1 | 31 | |
| GSE74704 | CYP4B1 | 1580 | 2 | 0 | 18 | |
| TCGA | CYP4B1 | 1580 | 10 | 17 | 69 |
Total number of gains: 50; Total number of losses: 32; Total Number of normals: 406.
Somatic mutations of CYP4B1:
Generating mutation plots.
Highly correlated genes for CYP4B1:
Showing top 20/1716 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP4B1 | SASH1 | 0.84151 | 11 | 0 | 11 |
| CYP4B1 | C5orf66-AS1 | 0.819558 | 6 | 0 | 6 |
| CYP4B1 | PCBP1-AS1 | 0.813008 | 4 | 0 | 4 |
| CYP4B1 | GDPD3 | 0.811937 | 11 | 0 | 11 |
| CYP4B1 | FAM3B | 0.807568 | 6 | 0 | 6 |
| CYP4B1 | CRISP3 | 0.807518 | 11 | 0 | 11 |
| CYP4B1 | UBL3 | 0.806466 | 11 | 0 | 11 |
| CYP4B1 | MGST2 | 0.805285 | 11 | 0 | 11 |
| CYP4B1 | CTTNBP2 | 0.804834 | 7 | 0 | 7 |
| CYP4B1 | SH3BGRL2 | 0.801681 | 8 | 0 | 7 |
| CYP4B1 | SPINK5 | 0.793549 | 11 | 0 | 11 |
| CYP4B1 | HPGD | 0.789515 | 11 | 0 | 11 |
| CYP4B1 | ACPP | 0.789335 | 11 | 0 | 11 |
| CYP4B1 | KRT78 | 0.787001 | 8 | 0 | 8 |
| CYP4B1 | MAL | 0.786997 | 12 | 0 | 12 |
| CYP4B1 | KIAA1211L | 0.786392 | 7 | 0 | 7 |
| CYP4B1 | EPHX2 | 0.785714 | 11 | 0 | 11 |
| CYP4B1 | ACOX3 | 0.784678 | 10 | 0 | 9 |
| CYP4B1 | ATP13A4 | 0.784603 | 7 | 0 | 7 |
| CYP4B1 | ARHGEF10L | 0.7846 | 11 | 0 | 11 |
For details and further investigation, click here
