| Full name: RNA 2',3'-cyclic phosphate and 5'-OH ligase | Alias Symbol: HSPC117|FAAP | ||
| Type: protein-coding gene | Cytoband: 22q12.3 | ||
| Entrez ID: 51493 | HGNC ID: HGNC:26935 | Ensembl Gene: ENSG00000100220 | OMIM ID: 613901 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RTCB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RTCB | 51493 | 200042_at | 0.0417 | 0.9594 | |
| GSE20347 | RTCB | 51493 | 200042_at | 0.1581 | 0.3225 | |
| GSE23400 | RTCB | 51493 | 200042_at | 0.1927 | 0.0006 | |
| GSE26886 | RTCB | 51493 | 200042_at | 0.0363 | 0.8443 | |
| GSE29001 | RTCB | 51493 | 200042_at | 0.1495 | 0.6854 | |
| GSE38129 | RTCB | 51493 | 200042_at | 0.2439 | 0.0173 | |
| GSE45670 | RTCB | 51493 | 200042_at | 0.1930 | 0.1369 | |
| GSE53622 | RTCB | 51493 | 16693 | 0.3020 | 0.0000 | |
| GSE53624 | RTCB | 51493 | 16693 | 0.2890 | 0.0001 | |
| GSE63941 | RTCB | 51493 | 200042_at | 0.0880 | 0.7988 | |
| GSE77861 | RTCB | 51493 | 200042_at | 0.4303 | 0.1735 | |
| SRP007169 | RTCB | 51493 | RNAseq | 0.8683 | 0.0454 | |
| SRP008496 | RTCB | 51493 | RNAseq | 0.9025 | 0.0112 | |
| SRP064894 | RTCB | 51493 | RNAseq | 0.1992 | 0.2001 | |
| SRP133303 | RTCB | 51493 | RNAseq | 0.4602 | 0.0147 | |
| SRP159526 | RTCB | 51493 | RNAseq | 0.1599 | 0.4724 | |
| SRP193095 | RTCB | 51493 | RNAseq | -0.1937 | 0.1668 | |
| SRP219564 | RTCB | 51493 | RNAseq | 0.1966 | 0.6692 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RTCB expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of RTCB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RTCB | 51493 | 4 | 5 | 21 | |
| GSE20123 | RTCB | 51493 | 4 | 4 | 22 | |
| GSE43470 | RTCB | 51493 | 4 | 5 | 34 | |
| GSE46452 | RTCB | 51493 | 31 | 1 | 27 | |
| GSE47630 | RTCB | 51493 | 8 | 5 | 27 | |
| GSE54993 | RTCB | 51493 | 3 | 6 | 61 | |
| GSE54994 | RTCB | 51493 | 10 | 9 | 34 | |
| GSE60625 | RTCB | 51493 | 5 | 0 | 6 | |
| GSE74703 | RTCB | 51493 | 4 | 5 | 27 | |
| GSE74704 | RTCB | 51493 | 1 | 1 | 18 | |
| TCGA | RTCB | 51493 | 27 | 15 | 54 |
Total number of gains: 101; Total number of losses: 56; Total Number of normals: 331.
Somatic mutations of RTCB:
Generating mutation plots.
Highly correlated genes for RTCB:
Showing top 20/301 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RTCB | DSC1 | 0.689814 | 3 | 0 | 3 |
| RTCB | DRG1 | 0.684001 | 11 | 0 | 10 |
| RTCB | NFKB1 | 0.683591 | 3 | 0 | 3 |
| RTCB | CNOT8 | 0.68006 | 4 | 0 | 4 |
| RTCB | ADSL | 0.670224 | 10 | 0 | 9 |
| RTCB | SAMM50 | 0.668669 | 9 | 0 | 7 |
| RTCB | PHF5A | 0.662954 | 6 | 0 | 5 |
| RTCB | MRPL45 | 0.654372 | 3 | 0 | 3 |
| RTCB | RECQL | 0.654109 | 3 | 0 | 3 |
| RTCB | C14orf119 | 0.652705 | 3 | 0 | 3 |
| RTCB | SLC25A17 | 0.650109 | 8 | 0 | 6 |
| RTCB | FBXL20 | 0.648684 | 3 | 0 | 3 |
| RTCB | DCTD | 0.647203 | 4 | 0 | 3 |
| RTCB | XRCC6 | 0.637566 | 11 | 0 | 10 |
| RTCB | TOMM22 | 0.631357 | 9 | 0 | 7 |
| RTCB | PRMT5 | 0.62538 | 5 | 0 | 5 |
| RTCB | COX4I1 | 0.625051 | 4 | 0 | 3 |
| RTCB | CREB1 | 0.622083 | 4 | 0 | 4 |
| RTCB | DACH1 | 0.619187 | 3 | 0 | 3 |
| RTCB | PRDX4 | 0.618684 | 5 | 0 | 4 |
For details and further investigation, click here
