| Full name: uroplakin 1B | Alias Symbol: TSPAN20 | ||
| Type: protein-coding gene | Cytoband: 3q13.32 | ||
| Entrez ID: 7348 | HGNC ID: HGNC:12578 | Ensembl Gene: ENSG00000114638 | OMIM ID: 602380 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UPK1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UPK1B | 7348 | 210065_s_at | 0.2353 | 0.9430 | |
| GSE20347 | UPK1B | 7348 | 210065_s_at | 0.8966 | 0.1827 | |
| GSE23400 | UPK1B | 7348 | 210064_s_at | 0.3604 | 0.1549 | |
| GSE26886 | UPK1B | 7348 | 210065_s_at | 0.2143 | 0.8308 | |
| GSE29001 | UPK1B | 7348 | 210065_s_at | 0.5883 | 0.6551 | |
| GSE38129 | UPK1B | 7348 | 210065_s_at | 1.3011 | 0.0244 | |
| GSE45670 | UPK1B | 7348 | 210065_s_at | 1.1262 | 0.3430 | |
| GSE53622 | UPK1B | 7348 | 42717 | 0.1483 | 0.7752 | |
| GSE53624 | UPK1B | 7348 | 42717 | -0.3044 | 0.4185 | |
| GSE63941 | UPK1B | 7348 | 210064_s_at | 1.4413 | 0.4650 | |
| GSE77861 | UPK1B | 7348 | 210065_s_at | 1.3088 | 0.4152 | |
| SRP007169 | UPK1B | 7348 | RNAseq | 2.3225 | 0.2022 | |
| SRP064894 | UPK1B | 7348 | RNAseq | -0.4272 | 0.5824 | |
| SRP133303 | UPK1B | 7348 | RNAseq | 3.9336 | 0.0001 | |
| SRP159526 | UPK1B | 7348 | RNAseq | 5.4767 | 0.0025 | |
| SRP193095 | UPK1B | 7348 | RNAseq | 2.2261 | 0.0000 | |
| SRP219564 | UPK1B | 7348 | RNAseq | -1.6101 | 0.0636 | |
| TCGA | UPK1B | 7348 | RNAseq | -0.0917 | 0.8799 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by UPK1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UPK1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UPK1B | 7348 | 17 | 0 | 13 | |
| GSE20123 | UPK1B | 7348 | 17 | 0 | 13 | |
| GSE43470 | UPK1B | 7348 | 21 | 1 | 21 | |
| GSE46452 | UPK1B | 7348 | 14 | 5 | 40 | |
| GSE47630 | UPK1B | 7348 | 16 | 5 | 19 | |
| GSE54993 | UPK1B | 7348 | 2 | 6 | 62 | |
| GSE54994 | UPK1B | 7348 | 30 | 4 | 19 | |
| GSE60625 | UPK1B | 7348 | 0 | 6 | 5 | |
| GSE74703 | UPK1B | 7348 | 17 | 1 | 18 | |
| GSE74704 | UPK1B | 7348 | 13 | 0 | 7 | |
| TCGA | UPK1B | 7348 | 53 | 7 | 36 |
Total number of gains: 200; Total number of losses: 35; Total Number of normals: 253.
Somatic mutations of UPK1B:
Generating mutation plots.
Highly correlated genes for UPK1B:
Showing all 20 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UPK1B | EAPP | 0.681689 | 3 | 0 | 3 |
| UPK1B | DACH1 | 0.615448 | 3 | 0 | 3 |
| UPK1B | DDX43 | 0.592613 | 4 | 0 | 3 |
| UPK1B | THAP11 | 0.589553 | 3 | 0 | 3 |
| UPK1B | DAZAP1 | 0.589467 | 3 | 0 | 3 |
| UPK1B | CTCF | 0.572972 | 5 | 0 | 3 |
| UPK1B | FBXO33 | 0.570191 | 3 | 0 | 3 |
| UPK1B | GOT2 | 0.563496 | 3 | 0 | 3 |
| UPK1B | ATP2B1 | 0.554321 | 4 | 0 | 3 |
| UPK1B | BRD1 | 0.552154 | 4 | 0 | 3 |
| UPK1B | UBA5 | 0.550488 | 4 | 0 | 3 |
| UPK1B | KANSL2 | 0.545035 | 4 | 0 | 3 |
| UPK1B | SLC27A5 | 0.542181 | 4 | 0 | 3 |
| UPK1B | BAG4 | 0.538679 | 3 | 0 | 3 |
| UPK1B | BDNF | 0.536741 | 7 | 0 | 3 |
| UPK1B | LRRC4 | 0.533731 | 6 | 0 | 4 |
| UPK1B | IST1 | 0.532531 | 4 | 0 | 3 |
| UPK1B | CALB1 | 0.52452 | 5 | 0 | 3 |
| UPK1B | SCN9A | 0.52432 | 5 | 0 | 3 |
| UPK1B | CHP2 | 0.515594 | 6 | 0 | 3 |
For details and further investigation, click here
