| Full name: growth factor receptor bound protein 7 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 2886 | HGNC ID: HGNC:4567 | Ensembl Gene: ENSG00000141738 | OMIM ID: 601522 |
| Drug and gene relationship at DGIdb | |||
Expression of GRB7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRB7 | 2886 | 210761_s_at | -0.7188 | 0.2657 | |
| GSE20347 | GRB7 | 2886 | 210761_s_at | -0.5046 | 0.0018 | |
| GSE23400 | GRB7 | 2886 | 210761_s_at | -0.6056 | 0.0000 | |
| GSE26886 | GRB7 | 2886 | 210761_s_at | -0.5098 | 0.0217 | |
| GSE29001 | GRB7 | 2886 | 210761_s_at | -0.3475 | 0.0481 | |
| GSE38129 | GRB7 | 2886 | 210761_s_at | -0.2762 | 0.2596 | |
| GSE45670 | GRB7 | 2886 | 210761_s_at | 0.0744 | 0.7585 | |
| GSE53622 | GRB7 | 2886 | 23232 | -0.4446 | 0.0120 | |
| GSE53624 | GRB7 | 2886 | 23232 | -0.7066 | 0.0000 | |
| GSE63941 | GRB7 | 2886 | 210761_s_at | 2.3413 | 0.0304 | |
| GSE77861 | GRB7 | 2886 | 210761_s_at | -0.1380 | 0.4969 | |
| GSE97050 | GRB7 | 2886 | A_23_P163992 | 0.4507 | 0.2870 | |
| SRP007169 | GRB7 | 2886 | RNAseq | 0.6248 | 0.4863 | |
| SRP008496 | GRB7 | 2886 | RNAseq | -1.8693 | 0.0000 | |
| SRP064894 | GRB7 | 2886 | RNAseq | -1.0498 | 0.0107 | |
| SRP133303 | GRB7 | 2886 | RNAseq | -1.0296 | 0.0000 | |
| SRP159526 | GRB7 | 2886 | RNAseq | -1.3947 | 0.0067 | |
| SRP193095 | GRB7 | 2886 | RNAseq | -0.5907 | 0.0032 | |
| SRP219564 | GRB7 | 2886 | RNAseq | -1.6371 | 0.1036 | |
| TCGA | GRB7 | 2886 | RNAseq | 0.3720 | 0.0164 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by GRB7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRB7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRB7 | 2886 | 9 | 1 | 20 | |
| GSE20123 | GRB7 | 2886 | 9 | 1 | 20 | |
| GSE43470 | GRB7 | 2886 | 1 | 1 | 41 | |
| GSE46452 | GRB7 | 2886 | 34 | 0 | 25 | |
| GSE47630 | GRB7 | 2886 | 8 | 1 | 31 | |
| GSE54993 | GRB7 | 2886 | 3 | 4 | 63 | |
| GSE54994 | GRB7 | 2886 | 9 | 5 | 39 | |
| GSE60625 | GRB7 | 2886 | 4 | 0 | 7 | |
| GSE74703 | GRB7 | 2886 | 1 | 0 | 35 | |
| GSE74704 | GRB7 | 2886 | 5 | 1 | 14 | |
| TCGA | GRB7 | 2886 | 23 | 8 | 65 |
Total number of gains: 106; Total number of losses: 22; Total Number of normals: 360.
Somatic mutations of GRB7:
Generating mutation plots.
Highly correlated genes for GRB7:
Showing top 20/609 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRB7 | EDARADD | 0.71488 | 3 | 0 | 3 |
| GRB7 | ARHGAP40 | 0.693325 | 3 | 0 | 3 |
| GRB7 | ELF3 | 0.669678 | 11 | 0 | 9 |
| GRB7 | FAAH2 | 0.669207 | 4 | 0 | 3 |
| GRB7 | CLDN4 | 0.665361 | 11 | 0 | 10 |
| GRB7 | DACH1 | 0.654271 | 3 | 0 | 3 |
| GRB7 | SPATA19 | 0.650601 | 4 | 0 | 4 |
| GRB7 | RNF39 | 0.650433 | 10 | 0 | 9 |
| GRB7 | SPTBN2 | 0.645756 | 6 | 0 | 5 |
| GRB7 | CDS1 | 0.643168 | 9 | 0 | 7 |
| GRB7 | FAM83F | 0.643138 | 4 | 0 | 4 |
| GRB7 | PAX9 | 0.642296 | 12 | 0 | 10 |
| GRB7 | TTC22 | 0.641559 | 11 | 0 | 9 |
| GRB7 | PRDM1 | 0.640222 | 9 | 0 | 8 |
| GRB7 | PRSS22 | 0.638417 | 10 | 0 | 10 |
| GRB7 | MIEN1 | 0.637268 | 4 | 0 | 3 |
| GRB7 | PAK6 | 0.636631 | 6 | 0 | 5 |
| GRB7 | RIPK4 | 0.634716 | 9 | 0 | 7 |
| GRB7 | SYCE3 | 0.633827 | 4 | 0 | 4 |
| GRB7 | NUAK2 | 0.630317 | 3 | 0 | 3 |
For details and further investigation, click here
