| Full name: ephrin B2 | Alias Symbol: LERK5|Htk-L|HTKL|MGC126226|MGC126227|MGC126228 | ||
| Type: protein-coding gene | Cytoband: 13q33.3 | ||
| Entrez ID: 1948 | HGNC ID: HGNC:3227 | Ensembl Gene: ENSG00000125266 | OMIM ID: 600527 |
| Drug and gene relationship at DGIdb | |||
EFNB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EFNB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EFNB2 | 1948 | 202668_at | 0.0200 | 0.9851 | |
| GSE20347 | EFNB2 | 1948 | 202668_at | 0.1886 | 0.4942 | |
| GSE23400 | EFNB2 | 1948 | 202668_at | 0.4663 | 0.0017 | |
| GSE26886 | EFNB2 | 1948 | 202668_at | 0.6474 | 0.2052 | |
| GSE29001 | EFNB2 | 1948 | 202668_at | 0.4955 | 0.1428 | |
| GSE38129 | EFNB2 | 1948 | 202668_at | 0.4115 | 0.0613 | |
| GSE45670 | EFNB2 | 1948 | 202668_at | 0.4726 | 0.1589 | |
| GSE53622 | EFNB2 | 1948 | 7253 | 0.2700 | 0.0294 | |
| GSE53624 | EFNB2 | 1948 | 7253 | 0.2946 | 0.0033 | |
| GSE63941 | EFNB2 | 1948 | 202668_at | 3.6824 | 0.0066 | |
| GSE77861 | EFNB2 | 1948 | 202668_at | 0.9139 | 0.0256 | |
| GSE97050 | EFNB2 | 1948 | A_24_P355944 | 0.1476 | 0.6191 | |
| SRP007169 | EFNB2 | 1948 | RNAseq | 1.5693 | 0.0205 | |
| SRP008496 | EFNB2 | 1948 | RNAseq | 1.4569 | 0.0015 | |
| SRP064894 | EFNB2 | 1948 | RNAseq | 0.6000 | 0.0313 | |
| SRP133303 | EFNB2 | 1948 | RNAseq | 0.7165 | 0.0039 | |
| SRP159526 | EFNB2 | 1948 | RNAseq | 0.7007 | 0.1015 | |
| SRP193095 | EFNB2 | 1948 | RNAseq | 0.1726 | 0.5034 | |
| SRP219564 | EFNB2 | 1948 | RNAseq | 0.0891 | 0.8645 | |
| TCGA | EFNB2 | 1948 | RNAseq | -0.0365 | 0.7082 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by EFNB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EFNB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EFNB2 | 1948 | 6 | 10 | 14 | |
| GSE20123 | EFNB2 | 1948 | 6 | 9 | 15 | |
| GSE43470 | EFNB2 | 1948 | 4 | 11 | 28 | |
| GSE46452 | EFNB2 | 1948 | 1 | 31 | 27 | |
| GSE47630 | EFNB2 | 1948 | 3 | 26 | 11 | |
| GSE54993 | EFNB2 | 1948 | 11 | 4 | 55 | |
| GSE54994 | EFNB2 | 1948 | 7 | 8 | 38 | |
| GSE60625 | EFNB2 | 1948 | 0 | 3 | 8 | |
| GSE74703 | EFNB2 | 1948 | 3 | 9 | 24 | |
| GSE74704 | EFNB2 | 1948 | 4 | 9 | 7 | |
| TCGA | EFNB2 | 1948 | 16 | 33 | 47 |
Total number of gains: 61; Total number of losses: 153; Total Number of normals: 274.
Somatic mutations of EFNB2:
Generating mutation plots.
Highly correlated genes for EFNB2:
Showing top 20/483 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EFNB2 | TRADD | 0.752659 | 3 | 0 | 3 |
| EFNB2 | IWS1 | 0.745579 | 4 | 0 | 4 |
| EFNB2 | DAD1 | 0.730095 | 3 | 0 | 3 |
| EFNB2 | SHANK3 | 0.728454 | 3 | 0 | 3 |
| EFNB2 | MRPS6 | 0.718406 | 3 | 0 | 3 |
| EFNB2 | HELZ | 0.706224 | 3 | 0 | 3 |
| EFNB2 | LMNA | 0.705044 | 4 | 0 | 4 |
| EFNB2 | CRIPT | 0.703496 | 3 | 0 | 3 |
| EFNB2 | ZBTB41 | 0.700292 | 3 | 0 | 3 |
| EFNB2 | SPECC1 | 0.68384 | 3 | 0 | 3 |
| EFNB2 | CLPTM1L | 0.680527 | 3 | 0 | 3 |
| EFNB2 | PIEZO1 | 0.679372 | 4 | 0 | 3 |
| EFNB2 | TMTC1 | 0.673042 | 3 | 0 | 3 |
| EFNB2 | GTPBP3 | 0.669735 | 3 | 0 | 3 |
| EFNB2 | ZFPL1 | 0.660022 | 3 | 0 | 3 |
| EFNB2 | SETBP1 | 0.652966 | 3 | 0 | 3 |
| EFNB2 | ASCC3 | 0.650514 | 4 | 0 | 3 |
| EFNB2 | KHNYN | 0.648988 | 3 | 0 | 3 |
| EFNB2 | STK17A | 0.648986 | 7 | 0 | 5 |
| EFNB2 | VMA21 | 0.648547 | 3 | 0 | 3 |
For details and further investigation, click here
