| Full name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | Alias Symbol: ST3O|SIATFL|ST3GalA.1 | ||
| Type: protein-coding gene | Cytoband: 8q24.22 | ||
| Entrez ID: 6482 | HGNC ID: HGNC:10862 | Ensembl Gene: ENSG00000008513 | OMIM ID: 607187 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ST3GAL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ST3GAL1 | 6482 | 225033_at | 0.8501 | 0.2102 | |
| GSE20347 | ST3GAL1 | 6482 | 208322_s_at | -0.1510 | 0.1602 | |
| GSE23400 | ST3GAL1 | 6482 | 208322_s_at | 0.0893 | 0.1847 | |
| GSE26886 | ST3GAL1 | 6482 | 208322_s_at | 0.2424 | 0.3966 | |
| GSE29001 | ST3GAL1 | 6482 | 208322_s_at | -0.1834 | 0.4928 | |
| GSE38129 | ST3GAL1 | 6482 | 208322_s_at | 0.0243 | 0.9052 | |
| GSE45670 | ST3GAL1 | 6482 | 208322_s_at | 0.2681 | 0.2865 | |
| GSE53622 | ST3GAL1 | 6482 | 25891 | -0.0744 | 0.5177 | |
| GSE53624 | ST3GAL1 | 6482 | 25891 | -0.2901 | 0.0113 | |
| GSE63941 | ST3GAL1 | 6482 | 225033_at | -1.5512 | 0.2116 | |
| GSE77861 | ST3GAL1 | 6482 | 225033_at | 0.1081 | 0.8281 | |
| GSE97050 | ST3GAL1 | 6482 | A_23_P31896 | 0.5291 | 0.1657 | |
| SRP007169 | ST3GAL1 | 6482 | RNAseq | 0.7731 | 0.2652 | |
| SRP008496 | ST3GAL1 | 6482 | RNAseq | 0.6245 | 0.1681 | |
| SRP064894 | ST3GAL1 | 6482 | RNAseq | -0.1463 | 0.5951 | |
| SRP133303 | ST3GAL1 | 6482 | RNAseq | 0.3342 | 0.2013 | |
| SRP159526 | ST3GAL1 | 6482 | RNAseq | 0.5219 | 0.0385 | |
| SRP193095 | ST3GAL1 | 6482 | RNAseq | 0.7131 | 0.0002 | |
| SRP219564 | ST3GAL1 | 6482 | RNAseq | -0.3004 | 0.4223 | |
| TCGA | ST3GAL1 | 6482 | RNAseq | -0.2099 | 0.0115 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ST3GAL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ST3GAL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ST3GAL1 | 6482 | 15 | 0 | 15 | |
| GSE20123 | ST3GAL1 | 6482 | 16 | 0 | 14 | |
| GSE43470 | ST3GAL1 | 6482 | 23 | 1 | 19 | |
| GSE46452 | ST3GAL1 | 6482 | 27 | 0 | 32 | |
| GSE47630 | ST3GAL1 | 6482 | 24 | 0 | 16 | |
| GSE54993 | ST3GAL1 | 6482 | 0 | 24 | 46 | |
| GSE54994 | ST3GAL1 | 6482 | 39 | 1 | 13 | |
| GSE60625 | ST3GAL1 | 6482 | 0 | 7 | 4 | |
| GSE74703 | ST3GAL1 | 6482 | 20 | 0 | 16 | |
| GSE74704 | ST3GAL1 | 6482 | 11 | 0 | 9 | |
| TCGA | ST3GAL1 | 6482 | 66 | 2 | 28 |
Total number of gains: 241; Total number of losses: 35; Total Number of normals: 212.
Somatic mutations of ST3GAL1:
Generating mutation plots.
Highly correlated genes for ST3GAL1:
Showing top 20/26 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ST3GAL1 | FERMT3 | 0.725331 | 3 | 0 | 3 |
| ST3GAL1 | ASCL2 | 0.723866 | 3 | 0 | 3 |
| ST3GAL1 | ADCK5 | 0.69177 | 4 | 0 | 3 |
| ST3GAL1 | DAPK2 | 0.686942 | 3 | 0 | 3 |
| ST3GAL1 | TLR6 | 0.66791 | 3 | 0 | 3 |
| ST3GAL1 | TRIM11 | 0.666826 | 3 | 0 | 3 |
| ST3GAL1 | PLEKHG4B | 0.63499 | 3 | 0 | 3 |
| ST3GAL1 | GGA1 | 0.629889 | 3 | 0 | 3 |
| ST3GAL1 | ALDH16A1 | 0.619344 | 4 | 0 | 4 |
| ST3GAL1 | FBXO15 | 0.611813 | 3 | 0 | 3 |
| ST3GAL1 | SLC4A11 | 0.610035 | 4 | 0 | 3 |
| ST3GAL1 | HOXD10 | 0.600207 | 3 | 0 | 3 |
| ST3GAL1 | MMP11 | 0.591155 | 3 | 0 | 3 |
| ST3GAL1 | ERCC5 | 0.588296 | 3 | 0 | 3 |
| ST3GAL1 | MAFB | 0.580898 | 3 | 0 | 3 |
| ST3GAL1 | MBD6 | 0.577276 | 4 | 0 | 4 |
| ST3GAL1 | NAPSA | 0.573557 | 3 | 0 | 3 |
| ST3GAL1 | NUDT14 | 0.564856 | 4 | 0 | 3 |
| ST3GAL1 | ABI3 | 0.562615 | 3 | 0 | 3 |
| ST3GAL1 | TMEM9 | 0.559275 | 3 | 0 | 3 |
For details and further investigation, click here
