| Full name: dimethylarginine dimethylaminohydrolase 2 | Alias Symbol: G6A | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 23564 | HGNC ID: HGNC:2716 | Ensembl Gene: ENSG00000213722 | OMIM ID: 604744 |
| Drug and gene relationship at DGIdb | |||
Expression of DDAH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDAH2 | 23564 | 215537_x_at | -0.6347 | 0.0642 | |
| GSE20347 | DDAH2 | 23564 | 215537_x_at | -0.7927 | 0.0000 | |
| GSE23400 | DDAH2 | 23564 | 215537_x_at | -0.5167 | 0.0000 | |
| GSE26886 | DDAH2 | 23564 | 202262_x_at | -0.9873 | 0.0004 | |
| GSE29001 | DDAH2 | 23564 | 215537_x_at | -1.1384 | 0.0129 | |
| GSE38129 | DDAH2 | 23564 | 215537_x_at | -0.8210 | 0.0000 | |
| GSE45670 | DDAH2 | 23564 | 215537_x_at | -1.0635 | 0.0000 | |
| GSE53622 | DDAH2 | 23564 | 56379 | -0.7865 | 0.0000 | |
| GSE53624 | DDAH2 | 23564 | 56379 | -0.9071 | 0.0000 | |
| GSE63941 | DDAH2 | 23564 | 202262_x_at | -1.4254 | 0.0075 | |
| GSE77861 | DDAH2 | 23564 | 215537_x_at | -0.2533 | 0.1651 | |
| GSE97050 | DDAH2 | 23564 | A_23_P19482 | -0.4634 | 0.2253 | |
| SRP007169 | DDAH2 | 23564 | RNAseq | -2.8080 | 0.0000 | |
| SRP008496 | DDAH2 | 23564 | RNAseq | -2.3641 | 0.0000 | |
| SRP064894 | DDAH2 | 23564 | RNAseq | -0.6307 | 0.0414 | |
| SRP133303 | DDAH2 | 23564 | RNAseq | -1.0143 | 0.0000 | |
| SRP159526 | DDAH2 | 23564 | RNAseq | -0.4271 | 0.2893 | |
| SRP193095 | DDAH2 | 23564 | RNAseq | -0.6234 | 0.0002 | |
| SRP219564 | DDAH2 | 23564 | RNAseq | -0.6322 | 0.1837 | |
| TCGA | DDAH2 | 23564 | RNAseq | -0.0497 | 0.5591 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by DDAH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDAH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDAH2 | 23564 | 5 | 1 | 24 | |
| GSE20123 | DDAH2 | 23564 | 5 | 1 | 24 | |
| GSE43470 | DDAH2 | 23564 | 5 | 1 | 37 | |
| GSE46452 | DDAH2 | 23564 | 1 | 10 | 48 | |
| GSE47630 | DDAH2 | 23564 | 7 | 4 | 29 | |
| GSE54993 | DDAH2 | 23564 | 2 | 1 | 67 | |
| GSE54994 | DDAH2 | 23564 | 11 | 4 | 38 | |
| GSE60625 | DDAH2 | 23564 | 0 | 1 | 10 | |
| GSE74703 | DDAH2 | 23564 | 5 | 0 | 31 | |
| GSE74704 | DDAH2 | 23564 | 2 | 0 | 18 | |
| TCGA | DDAH2 | 23564 | 16 | 16 | 64 |
Total number of gains: 59; Total number of losses: 39; Total Number of normals: 390.
Somatic mutations of DDAH2:
Generating mutation plots.
Highly correlated genes for DDAH2:
Showing top 20/1021 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDAH2 | FZD7 | 0.741745 | 3 | 0 | 3 |
| DDAH2 | RBPMS2 | 0.728475 | 5 | 0 | 5 |
| DDAH2 | RBFOX3 | 0.713885 | 3 | 0 | 3 |
| DDAH2 | MYZAP | 0.712433 | 3 | 0 | 3 |
| DDAH2 | AFF3 | 0.70922 | 3 | 0 | 3 |
| DDAH2 | SORCS1 | 0.699458 | 4 | 0 | 3 |
| DDAH2 | GSN | 0.698054 | 12 | 0 | 12 |
| DDAH2 | CFD | 0.695296 | 10 | 0 | 8 |
| DDAH2 | C1QTNF7 | 0.695142 | 5 | 0 | 4 |
| DDAH2 | GFRA1 | 0.692957 | 6 | 0 | 5 |
| DDAH2 | IL17D | 0.691565 | 5 | 0 | 4 |
| DDAH2 | PDZD4 | 0.688935 | 4 | 0 | 3 |
| DDAH2 | LRRN4CL | 0.687335 | 5 | 0 | 5 |
| DDAH2 | RUNX1T1 | 0.68259 | 5 | 0 | 5 |
| DDAH2 | MIR100HG | 0.681023 | 4 | 0 | 4 |
| DDAH2 | PLAC9 | 0.679112 | 6 | 0 | 5 |
| DDAH2 | ANGPTL1 | 0.678132 | 6 | 0 | 5 |
| DDAH2 | PRIMA1 | 0.677491 | 5 | 0 | 5 |
| DDAH2 | KMT2D | 0.676993 | 3 | 0 | 3 |
| DDAH2 | NEGR1 | 0.676325 | 6 | 0 | 5 |
For details and further investigation, click here
