| Full name: claudin 12 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q21.13 | ||
| Entrez ID: 9069 | HGNC ID: HGNC:2034 | Ensembl Gene: ENSG00000157224 | OMIM ID: 611232 |
| Drug and gene relationship at DGIdb | |||
Expression of CLDN12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN12 | 9069 | 223249_at | 0.0949 | 0.9011 | |
| GSE26886 | CLDN12 | 9069 | 223249_at | 0.2117 | 0.3765 | |
| GSE45670 | CLDN12 | 9069 | 223249_at | 0.6795 | 0.0009 | |
| GSE53622 | CLDN12 | 9069 | 75917 | 0.6777 | 0.0000 | |
| GSE53624 | CLDN12 | 9069 | 75917 | 0.5434 | 0.0000 | |
| GSE63941 | CLDN12 | 9069 | 223249_at | -0.0562 | 0.9401 | |
| GSE77861 | CLDN12 | 9069 | 223249_at | 0.6623 | 0.1076 | |
| GSE97050 | CLDN12 | 9069 | A_23_P412515 | 0.4913 | 0.1734 | |
| SRP007169 | CLDN12 | 9069 | RNAseq | 0.2977 | 0.4091 | |
| SRP008496 | CLDN12 | 9069 | RNAseq | 0.4402 | 0.1417 | |
| SRP064894 | CLDN12 | 9069 | RNAseq | 0.5554 | 0.0120 | |
| SRP133303 | CLDN12 | 9069 | RNAseq | 0.7186 | 0.0000 | |
| SRP159526 | CLDN12 | 9069 | RNAseq | 0.0191 | 0.9402 | |
| SRP193095 | CLDN12 | 9069 | RNAseq | 0.4959 | 0.0193 | |
| SRP219564 | CLDN12 | 9069 | RNAseq | 0.2202 | 0.4214 | |
| TCGA | CLDN12 | 9069 | RNAseq | 0.0350 | 0.6171 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CLDN12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN12 | 9069 | 13 | 1 | 16 | |
| GSE20123 | CLDN12 | 9069 | 13 | 0 | 17 | |
| GSE43470 | CLDN12 | 9069 | 6 | 1 | 36 | |
| GSE46452 | CLDN12 | 9069 | 11 | 0 | 48 | |
| GSE47630 | CLDN12 | 9069 | 9 | 2 | 29 | |
| GSE54993 | CLDN12 | 9069 | 1 | 8 | 61 | |
| GSE54994 | CLDN12 | 9069 | 17 | 2 | 34 | |
| GSE60625 | CLDN12 | 9069 | 0 | 0 | 11 | |
| GSE74703 | CLDN12 | 9069 | 5 | 1 | 30 | |
| GSE74704 | CLDN12 | 9069 | 9 | 0 | 11 | |
| TCGA | CLDN12 | 9069 | 55 | 5 | 36 |
Total number of gains: 139; Total number of losses: 20; Total Number of normals: 329.
Somatic mutations of CLDN12:
Generating mutation plots.
Highly correlated genes for CLDN12:
Showing top 20/772 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN12 | ASH2L | 0.851505 | 3 | 0 | 3 |
| CLDN12 | SPEN | 0.775359 | 3 | 0 | 3 |
| CLDN12 | SMAD3 | 0.774695 | 3 | 0 | 3 |
| CLDN12 | SBNO1 | 0.768795 | 3 | 0 | 3 |
| CLDN12 | ENTPD4 | 0.762282 | 4 | 0 | 3 |
| CLDN12 | TAF4B | 0.757918 | 3 | 0 | 3 |
| CLDN12 | CCT5 | 0.751099 | 3 | 0 | 3 |
| CLDN12 | TM2D2 | 0.74827 | 4 | 0 | 4 |
| CLDN12 | TNKS | 0.740409 | 4 | 0 | 4 |
| CLDN12 | ISY1 | 0.732623 | 3 | 0 | 3 |
| CLDN12 | GPX7 | 0.728171 | 3 | 0 | 3 |
| CLDN12 | EPHX4 | 0.726426 | 3 | 0 | 3 |
| CLDN12 | KCNE3 | 0.719539 | 3 | 0 | 3 |
| CLDN12 | PCDH18 | 0.718031 | 3 | 0 | 3 |
| CLDN12 | TRIB1 | 0.718027 | 3 | 0 | 3 |
| CLDN12 | SMC5 | 0.717946 | 3 | 0 | 3 |
| CLDN12 | NHS | 0.716574 | 3 | 0 | 3 |
| CLDN12 | DDHD2 | 0.710266 | 3 | 0 | 3 |
| CLDN12 | NEIL2 | 0.708992 | 3 | 0 | 3 |
| CLDN12 | IRF2BPL | 0.708613 | 3 | 0 | 3 |
For details and further investigation, click here
