DDX28

 

Full name: DEAD-box helicase 28 Alias Symbol: MDDX28|FLJ11282
Type: protein-coding gene Cytoband: 16q22.1
Entrez ID: 55794 HGNC ID: HGNC:17330 Ensembl Gene: ENSG00000182810 OMIM ID: 607618
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of DDX28:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DDX28 55794 40255_at 0.6158 0.0559
GSE20347 DDX28 55794 40255_at 0.4054 0.0039
GSE23400 DDX28 55794 203785_s_at 0.3801 0.0000
GSE26886 DDX28 55794 40255_at 0.0846 0.6418
GSE29001 DDX28 55794 40255_at 0.2783 0.1106
GSE38129 DDX28 55794 40255_at 0.4838 0.0001
GSE45670 DDX28 55794 40255_at 0.3095 0.0049
GSE53622 DDX28 55794 116751 0.4260 0.0000
GSE53624 DDX28 55794 116751 0.6086 0.0000
GSE63941 DDX28 55794 40255_at 0.6202 0.0742
GSE77861 DDX28 55794 40255_at 0.2529 0.1212
GSE97050 DDX28 55794 A_23_P106633 0.2178 0.5260
SRP007169 DDX28 55794 RNAseq 0.5393 0.2461
SRP008496 DDX28 55794 RNAseq 0.2668 0.3758
SRP064894 DDX28 55794 RNAseq 0.2232 0.2039
SRP133303 DDX28 55794 RNAseq 0.5215 0.0169
SRP159526 DDX28 55794 RNAseq 0.5850 0.1312
SRP193095 DDX28 55794 RNAseq 0.3401 0.0207
SRP219564 DDX28 55794 RNAseq 0.3613 0.3929
TCGA DDX28 55794 RNAseq 0.1613 0.0134

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by DDX28 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DDX28:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DDX28 55794 9 2 19
GSE20123 DDX28 55794 9 2 19
GSE43470 DDX28 55794 1 9 33
GSE46452 DDX28 55794 38 1 20
GSE47630 DDX28 55794 11 8 21
GSE54993 DDX28 55794 2 4 64
GSE54994 DDX28 55794 8 10 35
GSE60625 DDX28 55794 4 0 7
GSE74703 DDX28 55794 1 6 29
GSE74704 DDX28 55794 5 1 14
TCGA DDX28 55794 30 12 54

Total number of gains: 118; Total number of losses: 55; Total Number of normals: 315.  

 

Somatic mutations of DDX28:

 

Generating mutation plots.

 

Highly correlated genes for DDX28:

 

Showing top 20/1384 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DDX28IRF2BPL0.818183303
DDX28COPA0.76722303
DDX28LRRC8B0.75738404
DDX28KTI120.755018303
DDX28UBTD20.753649303
DDX28MED140.750742303
DDX28MOB3C0.748063303
DDX28NSD10.738793303
DDX28MRPL270.729629404
DDX28ZHX20.723404303
DDX28VASP0.722027303
DDX28NLK0.720874303
DDX28GORAB0.720792404
DDX28EMC80.718898908
DDX28PPIL10.716322505
DDX28CDCA20.71232403
DDX28ALG10.712262505
DDX28C8orf760.705324504
DDX28ATXN1L0.703555303
DDX28ACP10.700211606

For details and further investigation, click here