| Full name: coatomer protein complex subunit alpha | Alias Symbol: HEP-COP | ||
| Type: protein-coding gene | Cytoband: 1q23.2 | ||
| Entrez ID: 1314 | HGNC ID: HGNC:2230 | Ensembl Gene: ENSG00000122218 | OMIM ID: 601924 |
| Drug and gene relationship at DGIdb | |||
Expression of COPA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COPA | 1314 | 208684_at | 0.2368 | 0.3570 | |
| GSE20347 | COPA | 1314 | 208684_at | 0.1408 | 0.0932 | |
| GSE23400 | COPA | 1314 | 208684_at | 0.2563 | 0.0000 | |
| GSE26886 | COPA | 1314 | 208684_at | -0.5968 | 0.0208 | |
| GSE29001 | COPA | 1314 | 208684_at | 0.1766 | 0.3162 | |
| GSE38129 | COPA | 1314 | 208684_at | 0.1441 | 0.0626 | |
| GSE45670 | COPA | 1314 | 208684_at | 0.1844 | 0.1106 | |
| GSE63941 | COPA | 1314 | 208684_at | 0.0588 | 0.8772 | |
| GSE77861 | COPA | 1314 | 208684_at | 0.3516 | 0.0672 | |
| GSE97050 | COPA | 1314 | A_32_P20454 | -0.2850 | 0.3261 | |
| SRP007169 | COPA | 1314 | RNAseq | -0.3288 | 0.2625 | |
| SRP008496 | COPA | 1314 | RNAseq | -0.0188 | 0.9367 | |
| SRP064894 | COPA | 1314 | RNAseq | 0.2721 | 0.1022 | |
| SRP133303 | COPA | 1314 | RNAseq | 0.3360 | 0.0347 | |
| SRP159526 | COPA | 1314 | RNAseq | 0.4838 | 0.0000 | |
| SRP193095 | COPA | 1314 | RNAseq | 0.1899 | 0.0916 | |
| SRP219564 | COPA | 1314 | RNAseq | 0.4437 | 0.2478 | |
| TCGA | COPA | 1314 | RNAseq | -0.0101 | 0.7937 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COPA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of COPA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COPA | 1314 | 10 | 0 | 20 | |
| GSE20123 | COPA | 1314 | 10 | 0 | 20 | |
| GSE43470 | COPA | 1314 | 7 | 2 | 34 | |
| GSE46452 | COPA | 1314 | 2 | 1 | 56 | |
| GSE47630 | COPA | 1314 | 15 | 0 | 25 | |
| GSE54993 | COPA | 1314 | 0 | 5 | 65 | |
| GSE54994 | COPA | 1314 | 16 | 0 | 37 | |
| GSE60625 | COPA | 1314 | 0 | 0 | 11 | |
| GSE74703 | COPA | 1314 | 7 | 2 | 27 | |
| GSE74704 | COPA | 1314 | 4 | 0 | 16 | |
| TCGA | COPA | 1314 | 44 | 3 | 49 |
Total number of gains: 115; Total number of losses: 13; Total Number of normals: 360.
Somatic mutations of COPA:
Generating mutation plots.
Highly correlated genes for COPA:
Showing top 20/312 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COPA | ATG7 | 0.79542 | 3 | 0 | 3 |
| COPA | PPIP5K2 | 0.794253 | 3 | 0 | 3 |
| COPA | DDX28 | 0.76722 | 3 | 0 | 3 |
| COPA | SAE1 | 0.762494 | 3 | 0 | 3 |
| COPA | C1orf226 | 0.760624 | 3 | 0 | 3 |
| COPA | ISCA2 | 0.744309 | 3 | 0 | 3 |
| COPA | RAB12 | 0.733114 | 3 | 0 | 3 |
| COPA | RAB22A | 0.732807 | 3 | 0 | 3 |
| COPA | KHNYN | 0.722493 | 3 | 0 | 3 |
| COPA | ECI2 | 0.720988 | 3 | 0 | 3 |
| COPA | CNTNAP2 | 0.720592 | 3 | 0 | 3 |
| COPA | AGPAT5 | 0.714501 | 3 | 0 | 3 |
| COPA | NAA20 | 0.705736 | 3 | 0 | 3 |
| COPA | MKNK1 | 0.705053 | 4 | 0 | 3 |
| COPA | SEC16A | 0.703503 | 3 | 0 | 3 |
| COPA | DHTKD1 | 0.691607 | 3 | 0 | 3 |
| COPA | C16orf70 | 0.686147 | 3 | 0 | 3 |
| COPA | SAMM50 | 0.682927 | 4 | 0 | 3 |
| COPA | CDC123 | 0.682121 | 5 | 0 | 4 |
| COPA | RTN4R | 0.676295 | 4 | 0 | 4 |
For details and further investigation, click here
