| Full name: vasodilator stimulated phosphoprotein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 7408 | HGNC ID: HGNC:12652 | Ensembl Gene: ENSG00000125753 | OMIM ID: 601703 |
| Drug and gene relationship at DGIdb | |||
VASP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04611 | Platelet activation | |
| hsa04666 | Fc gamma R-mediated phagocytosis |
Expression of VASP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VASP | 7408 | 202205_at | 0.2576 | 0.4233 | |
| GSE20347 | VASP | 7408 | 202205_at | 0.0337 | 0.8093 | |
| GSE23400 | VASP | 7408 | 202205_at | 0.0684 | 0.2640 | |
| GSE26886 | VASP | 7408 | 202205_at | 0.0297 | 0.9184 | |
| GSE29001 | VASP | 7408 | 202205_at | 0.1764 | 0.3169 | |
| GSE38129 | VASP | 7408 | 202205_at | -0.0547 | 0.7228 | |
| GSE45670 | VASP | 7408 | 202205_at | 0.3485 | 0.0130 | |
| GSE53622 | VASP | 7408 | 10727 | -0.1965 | 0.1359 | |
| GSE53624 | VASP | 7408 | 10727 | 0.2896 | 0.0001 | |
| GSE63941 | VASP | 7408 | 202205_at | -0.0563 | 0.8836 | |
| GSE77861 | VASP | 7408 | 202205_at | 0.4523 | 0.1190 | |
| GSE97050 | VASP | 7408 | A_23_P119102 | 0.2513 | 0.3811 | |
| SRP007169 | VASP | 7408 | RNAseq | 1.5472 | 0.0075 | |
| SRP008496 | VASP | 7408 | RNAseq | 1.4770 | 0.0001 | |
| SRP064894 | VASP | 7408 | RNAseq | 0.5716 | 0.0096 | |
| SRP133303 | VASP | 7408 | RNAseq | 0.6257 | 0.0093 | |
| SRP159526 | VASP | 7408 | RNAseq | 0.1302 | 0.6757 | |
| SRP193095 | VASP | 7408 | RNAseq | 0.1646 | 0.4702 | |
| SRP219564 | VASP | 7408 | RNAseq | -0.2028 | 0.6916 | |
| TCGA | VASP | 7408 | RNAseq | -0.0729 | 0.1091 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by VASP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VASP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VASP | 7408 | 4 | 5 | 21 | |
| GSE20123 | VASP | 7408 | 4 | 4 | 22 | |
| GSE43470 | VASP | 7408 | 3 | 11 | 29 | |
| GSE46452 | VASP | 7408 | 45 | 1 | 13 | |
| GSE47630 | VASP | 7408 | 8 | 6 | 26 | |
| GSE54993 | VASP | 7408 | 17 | 4 | 49 | |
| GSE54994 | VASP | 7408 | 6 | 12 | 35 | |
| GSE60625 | VASP | 7408 | 9 | 0 | 2 | |
| GSE74703 | VASP | 7408 | 3 | 7 | 26 | |
| GSE74704 | VASP | 7408 | 4 | 2 | 14 | |
| TCGA | VASP | 7408 | 14 | 17 | 65 |
Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.
Somatic mutations of VASP:
Generating mutation plots.
Highly correlated genes for VASP:
Showing top 20/600 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VASP | CCDC88A | 0.773895 | 3 | 0 | 3 |
| VASP | PRRX2 | 0.739944 | 3 | 0 | 3 |
| VASP | TMEM54 | 0.734028 | 3 | 0 | 3 |
| VASP | TRIM35 | 0.728777 | 3 | 0 | 3 |
| VASP | DDX28 | 0.722027 | 3 | 0 | 3 |
| VASP | LTBP2 | 0.721902 | 4 | 0 | 4 |
| VASP | SYMPK | 0.720648 | 3 | 0 | 3 |
| VASP | NACC1 | 0.717094 | 4 | 0 | 4 |
| VASP | SPIRE1 | 0.715496 | 3 | 0 | 3 |
| VASP | HNRNPC | 0.714927 | 5 | 0 | 5 |
| VASP | SLC16A2 | 0.709428 | 3 | 0 | 3 |
| VASP | BRAT1 | 0.709273 | 3 | 0 | 3 |
| VASP | PTGFRN | 0.703747 | 4 | 0 | 3 |
| VASP | RPN1 | 0.6996 | 3 | 0 | 3 |
| VASP | ZNF827 | 0.697654 | 4 | 0 | 3 |
| VASP | MOB3C | 0.695376 | 3 | 0 | 3 |
| VASP | ARL13B | 0.691668 | 3 | 0 | 3 |
| VASP | RP9 | 0.689963 | 3 | 0 | 3 |
| VASP | SYNC | 0.687193 | 3 | 0 | 3 |
| VASP | ADRM1 | 0.685182 | 5 | 0 | 4 |
For details and further investigation, click here
