| Full name: mitochondrial ribosomal protein L27 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 51264 | HGNC ID: HGNC:14483 | Ensembl Gene: ENSG00000108826 | OMIM ID: 611837 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPL27:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL27 | 51264 | 224330_s_at | -0.0241 | 0.9251 | |
| GSE26886 | MRPL27 | 51264 | 224330_s_at | -0.4699 | 0.0553 | |
| GSE45670 | MRPL27 | 51264 | 224330_s_at | 0.2478 | 0.0337 | |
| GSE53622 | MRPL27 | 51264 | 18250 | 0.0422 | 0.6445 | |
| GSE53624 | MRPL27 | 51264 | 18250 | 0.3624 | 0.0000 | |
| GSE63941 | MRPL27 | 51264 | 224330_s_at | 0.3549 | 0.1127 | |
| GSE77861 | MRPL27 | 51264 | 224330_s_at | 0.1179 | 0.4622 | |
| GSE97050 | MRPL27 | 51264 | A_23_P49768 | 0.1664 | 0.4544 | |
| SRP007169 | MRPL27 | 51264 | RNAseq | -0.1664 | 0.6254 | |
| SRP008496 | MRPL27 | 51264 | RNAseq | -0.4257 | 0.0966 | |
| SRP064894 | MRPL27 | 51264 | RNAseq | 0.8971 | 0.0181 | |
| SRP133303 | MRPL27 | 51264 | RNAseq | 0.2788 | 0.0652 | |
| SRP159526 | MRPL27 | 51264 | RNAseq | 0.0722 | 0.6133 | |
| SRP193095 | MRPL27 | 51264 | RNAseq | -0.3465 | 0.0013 | |
| SRP219564 | MRPL27 | 51264 | RNAseq | 0.3902 | 0.3007 | |
| TCGA | MRPL27 | 51264 | RNAseq | -0.0584 | 0.2964 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPL27 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL27:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL27 | 51264 | 5 | 2 | 23 | |
| GSE20123 | MRPL27 | 51264 | 5 | 2 | 23 | |
| GSE43470 | MRPL27 | 51264 | 3 | 2 | 38 | |
| GSE46452 | MRPL27 | 51264 | 32 | 0 | 27 | |
| GSE47630 | MRPL27 | 51264 | 9 | 0 | 31 | |
| GSE54993 | MRPL27 | 51264 | 2 | 4 | 64 | |
| GSE54994 | MRPL27 | 51264 | 9 | 6 | 38 | |
| GSE60625 | MRPL27 | 51264 | 4 | 0 | 7 | |
| GSE74703 | MRPL27 | 51264 | 3 | 2 | 31 | |
| GSE74704 | MRPL27 | 51264 | 4 | 1 | 15 | |
| TCGA | MRPL27 | 51264 | 27 | 7 | 62 |
Total number of gains: 103; Total number of losses: 26; Total Number of normals: 359.
Somatic mutations of MRPL27:
Generating mutation plots.
Highly correlated genes for MRPL27:
Showing top 20/215 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL27 | RTN3 | 0.785451 | 3 | 0 | 3 |
| MRPL27 | YLPM1 | 0.772594 | 3 | 0 | 3 |
| MRPL27 | CXorf40B | 0.752138 | 3 | 0 | 3 |
| MRPL27 | GLUD1 | 0.749137 | 3 | 0 | 3 |
| MRPL27 | KTI12 | 0.738187 | 3 | 0 | 3 |
| MRPL27 | MRPL14 | 0.733475 | 3 | 0 | 3 |
| MRPL27 | TNKS2 | 0.730374 | 3 | 0 | 3 |
| MRPL27 | CNOT10 | 0.729735 | 3 | 0 | 3 |
| MRPL27 | DDX28 | 0.729629 | 4 | 0 | 4 |
| MRPL27 | PLEKHJ1 | 0.728301 | 3 | 0 | 3 |
| MRPL27 | ILF2 | 0.72335 | 3 | 0 | 3 |
| MRPL27 | NDUFA13 | 0.719482 | 4 | 0 | 3 |
| MRPL27 | POLDIP2 | 0.718849 | 3 | 0 | 3 |
| MRPL27 | GPHN | 0.718521 | 3 | 0 | 3 |
| MRPL27 | DDX54 | 0.717323 | 3 | 0 | 3 |
| MRPL27 | LRRC59 | 0.712176 | 3 | 0 | 3 |
| MRPL27 | BAD | 0.709525 | 4 | 0 | 4 |
| MRPL27 | AGK | 0.708553 | 3 | 0 | 3 |
| MRPL27 | PPID | 0.705795 | 3 | 0 | 3 |
| MRPL27 | EBPL | 0.702211 | 3 | 0 | 3 |
For details and further investigation, click here
