| Full name: DEAD-box helicase 4 | Alias Symbol: VASA | ||
| Type: protein-coding gene | Cytoband: 5q11.2 | ||
| Entrez ID: 54514 | HGNC ID: HGNC:18700 | Ensembl Gene: ENSG00000152670 | OMIM ID: 605281 |
| Drug and gene relationship at DGIdb | |||
Expression of DDX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX4 | 54514 | 221630_s_at | -0.1987 | 0.4212 | |
| GSE20347 | DDX4 | 54514 | 221630_s_at | -0.0225 | 0.7512 | |
| GSE23400 | DDX4 | 54514 | 221630_s_at | -0.1283 | 0.0006 | |
| GSE26886 | DDX4 | 54514 | 221630_s_at | 0.0344 | 0.7528 | |
| GSE29001 | DDX4 | 54514 | 221630_s_at | -0.1193 | 0.3610 | |
| GSE38129 | DDX4 | 54514 | 221630_s_at | -0.0451 | 0.4655 | |
| GSE45670 | DDX4 | 54514 | 221630_s_at | 0.0210 | 0.8164 | |
| GSE53622 | DDX4 | 54514 | 74678 | 0.0312 | 0.8647 | |
| GSE53624 | DDX4 | 54514 | 74678 | -0.0207 | 0.8989 | |
| GSE63941 | DDX4 | 54514 | 221630_s_at | -0.0411 | 0.8018 | |
| GSE77861 | DDX4 | 54514 | 221630_s_at | -0.0844 | 0.4203 | |
| TCGA | DDX4 | 54514 | RNAseq | 1.3837 | 0.4634 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DDX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX4 | 54514 | 0 | 13 | 17 | |
| GSE20123 | DDX4 | 54514 | 0 | 13 | 17 | |
| GSE43470 | DDX4 | 54514 | 1 | 12 | 30 | |
| GSE46452 | DDX4 | 54514 | 1 | 27 | 31 | |
| GSE47630 | DDX4 | 54514 | 2 | 16 | 22 | |
| GSE54993 | DDX4 | 54514 | 8 | 1 | 61 | |
| GSE54994 | DDX4 | 54514 | 3 | 19 | 31 | |
| GSE60625 | DDX4 | 54514 | 0 | 0 | 11 | |
| GSE74703 | DDX4 | 54514 | 1 | 9 | 26 | |
| GSE74704 | DDX4 | 54514 | 0 | 6 | 14 | |
| TCGA | DDX4 | 54514 | 7 | 46 | 43 |
Total number of gains: 23; Total number of losses: 162; Total Number of normals: 303.
Somatic mutations of DDX4:
Generating mutation plots.
Highly correlated genes for DDX4:
Showing top 20/516 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX4 | ADCYAP1 | 0.748074 | 3 | 0 | 3 |
| DDX4 | EDDM3A | 0.704955 | 3 | 0 | 3 |
| DDX4 | CA5A | 0.704798 | 3 | 0 | 3 |
| DDX4 | HRH4 | 0.70305 | 3 | 0 | 3 |
| DDX4 | SEZ6L | 0.6934 | 3 | 0 | 3 |
| DDX4 | CCL24 | 0.690512 | 4 | 0 | 4 |
| DDX4 | SCGB1D1 | 0.688905 | 3 | 0 | 3 |
| DDX4 | NLGN4Y | 0.685937 | 3 | 0 | 3 |
| DDX4 | WWP2 | 0.683596 | 3 | 0 | 3 |
| DDX4 | CD1B | 0.682894 | 3 | 0 | 3 |
| DDX4 | CLEC1B | 0.681693 | 4 | 0 | 4 |
| DDX4 | TEK | 0.675085 | 3 | 0 | 3 |
| DDX4 | OR2S2 | 0.674854 | 3 | 0 | 3 |
| DDX4 | IRS4 | 0.661085 | 3 | 0 | 3 |
| DDX4 | KLK3 | 0.658848 | 3 | 0 | 3 |
| DDX4 | FRMD1 | 0.657941 | 5 | 0 | 4 |
| DDX4 | OR2J3 | 0.656539 | 5 | 0 | 5 |
| DDX4 | TAL1 | 0.654887 | 5 | 0 | 3 |
| DDX4 | CISH | 0.654555 | 4 | 0 | 3 |
| DDX4 | TTR | 0.650665 | 3 | 0 | 3 |
For details and further investigation, click here
