| Full name: DEAD-box helicase 41 | Alias Symbol: ABS|MGC8828 | ||
| Type: protein-coding gene | Cytoband: 5q35.3 | ||
| Entrez ID: 51428 | HGNC ID: HGNC:18674 | Ensembl Gene: ENSG00000183258 | OMIM ID: 608170 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX41:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX41 | 51428 | 217840_at | 0.4309 | 0.1616 | |
| GSE20347 | DDX41 | 51428 | 217840_at | -0.1657 | 0.2771 | |
| GSE23400 | DDX41 | 51428 | 217840_at | 0.1399 | 0.0700 | |
| GSE26886 | DDX41 | 51428 | 217840_at | -0.5321 | 0.0406 | |
| GSE29001 | DDX41 | 51428 | 217840_at | 0.0452 | 0.9153 | |
| GSE38129 | DDX41 | 51428 | 217840_at | 0.0272 | 0.8313 | |
| GSE45670 | DDX41 | 51428 | 217840_at | -0.0630 | 0.7524 | |
| GSE53622 | DDX41 | 51428 | 39807 | 0.1837 | 0.0063 | |
| GSE53624 | DDX41 | 51428 | 39807 | 0.0851 | 0.1481 | |
| GSE63941 | DDX41 | 51428 | 217840_at | 1.2469 | 0.0006 | |
| GSE77861 | DDX41 | 51428 | 217840_at | 0.0339 | 0.9112 | |
| GSE97050 | DDX41 | 51428 | A_23_P122116 | 0.2261 | 0.3056 | |
| SRP007169 | DDX41 | 51428 | RNAseq | -0.4393 | 0.2565 | |
| SRP008496 | DDX41 | 51428 | RNAseq | -0.7992 | 0.0019 | |
| SRP064894 | DDX41 | 51428 | RNAseq | 0.2254 | 0.1005 | |
| SRP133303 | DDX41 | 51428 | RNAseq | 0.1166 | 0.4320 | |
| SRP159526 | DDX41 | 51428 | RNAseq | -0.0673 | 0.7363 | |
| SRP193095 | DDX41 | 51428 | RNAseq | -0.0548 | 0.6627 | |
| SRP219564 | DDX41 | 51428 | RNAseq | 0.2565 | 0.4890 | |
| TCGA | DDX41 | 51428 | RNAseq | 0.1361 | 0.0073 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DDX41 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX41:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX41 | 51428 | 2 | 13 | 15 | |
| GSE20123 | DDX41 | 51428 | 2 | 13 | 15 | |
| GSE43470 | DDX41 | 51428 | 1 | 11 | 31 | |
| GSE46452 | DDX41 | 51428 | 0 | 27 | 32 | |
| GSE47630 | DDX41 | 51428 | 1 | 20 | 19 | |
| GSE54993 | DDX41 | 51428 | 10 | 2 | 58 | |
| GSE54994 | DDX41 | 51428 | 2 | 17 | 34 | |
| GSE60625 | DDX41 | 51428 | 1 | 0 | 10 | |
| GSE74703 | DDX41 | 51428 | 1 | 7 | 28 | |
| GSE74704 | DDX41 | 51428 | 1 | 6 | 13 | |
| TCGA | DDX41 | 51428 | 8 | 34 | 54 |
Total number of gains: 29; Total number of losses: 150; Total Number of normals: 309.
Somatic mutations of DDX41:
Generating mutation plots.
Highly correlated genes for DDX41:
Showing top 20/434 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX41 | DARS2 | 0.748105 | 3 | 0 | 3 |
| DDX41 | NUP155 | 0.717017 | 3 | 0 | 3 |
| DDX41 | C1orf112 | 0.694361 | 3 | 0 | 3 |
| DDX41 | KNTC1 | 0.690073 | 3 | 0 | 3 |
| DDX41 | DSCC1 | 0.687076 | 3 | 0 | 3 |
| DDX41 | STIL | 0.675964 | 4 | 0 | 3 |
| DDX41 | TPX2 | 0.675171 | 4 | 0 | 3 |
| DDX41 | STARD3 | 0.669424 | 3 | 0 | 3 |
| DDX41 | SNRPE | 0.666227 | 3 | 0 | 3 |
| DDX41 | CKS1B | 0.665104 | 4 | 0 | 3 |
| DDX41 | TBC1D22A | 0.664828 | 3 | 0 | 3 |
| DDX41 | NEK2 | 0.662539 | 4 | 0 | 3 |
| DDX41 | SLC25A39 | 0.661984 | 7 | 0 | 6 |
| DDX41 | ZNF837 | 0.659211 | 3 | 0 | 3 |
| DDX41 | CDK18 | 0.654452 | 3 | 0 | 3 |
| DDX41 | POLA1 | 0.653085 | 3 | 0 | 3 |
| DDX41 | CCT6A | 0.65032 | 3 | 0 | 3 |
| DDX41 | RPP38 | 0.648337 | 3 | 0 | 3 |
| DDX41 | MOCS3 | 0.645355 | 3 | 0 | 3 |
| DDX41 | PLK1 | 0.644949 | 4 | 0 | 3 |
For details and further investigation, click here
