| Full name: TPX2 microtubule nucleation factor | Alias Symbol: p100|DIL-2 | ||
| Type: protein-coding gene | Cytoband: 20q11.21 | ||
| Entrez ID: 22974 | HGNC ID: HGNC:1249 | Ensembl Gene: ENSG00000088325 | OMIM ID: 605917 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TPX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPX2 | 22974 | 210052_s_at | 2.1026 | 0.0075 | |
| GSE20347 | TPX2 | 22974 | 210052_s_at | 1.6260 | 0.0000 | |
| GSE23400 | TPX2 | 22974 | 210052_s_at | 1.3733 | 0.0000 | |
| GSE26886 | TPX2 | 22974 | 210052_s_at | 0.9300 | 0.0029 | |
| GSE29001 | TPX2 | 22974 | 210052_s_at | 1.7541 | 0.0000 | |
| GSE38129 | TPX2 | 22974 | 210052_s_at | 2.2106 | 0.0000 | |
| GSE45670 | TPX2 | 22974 | 210052_s_at | 1.7459 | 0.0000 | |
| GSE53622 | TPX2 | 22974 | 115100 | 2.3643 | 0.0000 | |
| GSE53624 | TPX2 | 22974 | 115100 | 2.4731 | 0.0000 | |
| GSE63941 | TPX2 | 22974 | 210052_s_at | 4.0486 | 0.0000 | |
| GSE77861 | TPX2 | 22974 | 210052_s_at | 1.0929 | 0.0148 | |
| GSE97050 | TPX2 | 22974 | A_23_P68610 | 2.5764 | 0.1110 | |
| SRP007169 | TPX2 | 22974 | RNAseq | 2.8058 | 0.0000 | |
| SRP008496 | TPX2 | 22974 | RNAseq | 2.5633 | 0.0000 | |
| SRP064894 | TPX2 | 22974 | RNAseq | 2.2778 | 0.0000 | |
| SRP133303 | TPX2 | 22974 | RNAseq | 1.8066 | 0.0000 | |
| SRP159526 | TPX2 | 22974 | RNAseq | 1.6232 | 0.0000 | |
| SRP193095 | TPX2 | 22974 | RNAseq | 1.4218 | 0.0000 | |
| SRP219564 | TPX2 | 22974 | RNAseq | 1.9751 | 0.0038 | |
| TCGA | TPX2 | 22974 | RNAseq | 1.1396 | 0.0000 |
Upregulated datasets: 18; Downregulated datasets: 0.
Survival by TPX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPX2 | 22974 | 14 | 0 | 16 | |
| GSE20123 | TPX2 | 22974 | 14 | 0 | 16 | |
| GSE43470 | TPX2 | 22974 | 11 | 0 | 32 | |
| GSE46452 | TPX2 | 22974 | 29 | 0 | 30 | |
| GSE47630 | TPX2 | 22974 | 25 | 0 | 15 | |
| GSE54993 | TPX2 | 22974 | 0 | 18 | 52 | |
| GSE54994 | TPX2 | 22974 | 27 | 1 | 25 | |
| GSE60625 | TPX2 | 22974 | 0 | 0 | 11 | |
| GSE74703 | TPX2 | 22974 | 10 | 0 | 26 | |
| GSE74704 | TPX2 | 22974 | 9 | 0 | 11 | |
| TCGA | TPX2 | 22974 | 49 | 1 | 46 |
Total number of gains: 188; Total number of losses: 20; Total Number of normals: 280.
Somatic mutations of TPX2:
Generating mutation plots.
Highly correlated genes for TPX2:
Showing top 20/2056 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPX2 | UBE2C | 0.896949 | 13 | 0 | 13 |
| TPX2 | KIF4A | 0.890246 | 12 | 0 | 12 |
| TPX2 | CENPF | 0.888696 | 12 | 0 | 12 |
| TPX2 | AURKB | 0.881489 | 13 | 0 | 13 |
| TPX2 | KIF20A | 0.864354 | 13 | 0 | 13 |
| TPX2 | TOP2A | 0.864201 | 13 | 0 | 13 |
| TPX2 | MYBL2 | 0.861431 | 12 | 0 | 12 |
| TPX2 | CDKN3 | 0.861238 | 13 | 0 | 13 |
| TPX2 | NEK2 | 0.857555 | 13 | 0 | 12 |
| TPX2 | STIL | 0.857379 | 12 | 0 | 12 |
| TPX2 | BIRC5 | 0.856083 | 12 | 0 | 12 |
| TPX2 | NCAPH | 0.855709 | 9 | 0 | 9 |
| TPX2 | KIF14 | 0.855699 | 13 | 0 | 13 |
| TPX2 | GINS1 | 0.855416 | 12 | 0 | 12 |
| TPX2 | CCNB2 | 0.854543 | 12 | 0 | 12 |
| TPX2 | CKS1B | 0.850949 | 13 | 0 | 13 |
| TPX2 | CDC20 | 0.849279 | 12 | 0 | 11 |
| TPX2 | AURKA | 0.847115 | 13 | 0 | 13 |
| TPX2 | DLGAP5 | 0.846687 | 13 | 0 | 13 |
| TPX2 | BUB1 | 0.844821 | 11 | 0 | 11 |
For details and further investigation, click here
