| Full name: DNA replication and sister chromatid cohesion 1 | Alias Symbol: DCC1|hDCC1|MGC5528 | ||
| Type: protein-coding gene | Cytoband: 8q24.12 | ||
| Entrez ID: 79075 | HGNC ID: HGNC:24453 | Ensembl Gene: ENSG00000136982 | OMIM ID: 613203 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DSCC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSCC1 | 79075 | 219000_s_at | 1.5539 | 0.0088 | |
| GSE20347 | DSCC1 | 79075 | 219000_s_at | 1.4044 | 0.0000 | |
| GSE23400 | DSCC1 | 79075 | 219000_s_at | 0.5526 | 0.0000 | |
| GSE26886 | DSCC1 | 79075 | 219000_s_at | 0.9830 | 0.0021 | |
| GSE29001 | DSCC1 | 79075 | 219000_s_at | 1.1737 | 0.0014 | |
| GSE38129 | DSCC1 | 79075 | 219000_s_at | 1.4575 | 0.0000 | |
| GSE45670 | DSCC1 | 79075 | 219000_s_at | 0.9683 | 0.0012 | |
| GSE63941 | DSCC1 | 79075 | 219000_s_at | 1.6725 | 0.0191 | |
| GSE77861 | DSCC1 | 79075 | 219000_s_at | 0.9970 | 0.0020 | |
| GSE97050 | DSCC1 | 79075 | A_23_P252740 | 0.5734 | 0.1360 | |
| SRP007169 | DSCC1 | 79075 | RNAseq | 2.0680 | 0.0004 | |
| SRP008496 | DSCC1 | 79075 | RNAseq | 1.8924 | 0.0000 | |
| SRP064894 | DSCC1 | 79075 | RNAseq | 1.6352 | 0.0000 | |
| SRP133303 | DSCC1 | 79075 | RNAseq | 1.6568 | 0.0000 | |
| SRP159526 | DSCC1 | 79075 | RNAseq | 1.4347 | 0.0004 | |
| SRP193095 | DSCC1 | 79075 | RNAseq | 1.2717 | 0.0000 | |
| SRP219564 | DSCC1 | 79075 | RNAseq | 1.3611 | 0.0001 | |
| TCGA | DSCC1 | 79075 | RNAseq | 0.7234 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by DSCC1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DSCC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSCC1 | 79075 | 19 | 1 | 10 | |
| GSE20123 | DSCC1 | 79075 | 20 | 1 | 9 | |
| GSE43470 | DSCC1 | 79075 | 23 | 0 | 20 | |
| GSE46452 | DSCC1 | 79075 | 27 | 0 | 32 | |
| GSE47630 | DSCC1 | 79075 | 24 | 0 | 16 | |
| GSE54993 | DSCC1 | 79075 | 0 | 20 | 50 | |
| GSE54994 | DSCC1 | 79075 | 37 | 0 | 16 | |
| GSE60625 | DSCC1 | 79075 | 0 | 4 | 7 | |
| GSE74703 | DSCC1 | 79075 | 19 | 0 | 17 | |
| GSE74704 | DSCC1 | 79075 | 13 | 1 | 6 | |
| TCGA | DSCC1 | 79075 | 67 | 2 | 27 |
Total number of gains: 249; Total number of losses: 29; Total Number of normals: 210.
Somatic mutations of DSCC1:
Generating mutation plots.
Highly correlated genes for DSCC1:
Showing top 20/1935 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSCC1 | PSMG3 | 0.802081 | 4 | 0 | 4 |
| DSCC1 | RPF2 | 0.800694 | 3 | 0 | 3 |
| DSCC1 | TBC1D31 | 0.800012 | 9 | 0 | 9 |
| DSCC1 | CENPBD1 | 0.798008 | 3 | 0 | 3 |
| DSCC1 | FOXM1 | 0.782467 | 9 | 0 | 9 |
| DSCC1 | CLPTM1L | 0.779884 | 4 | 0 | 4 |
| DSCC1 | ZBTB9 | 0.778369 | 3 | 0 | 3 |
| DSCC1 | SPAG5 | 0.772792 | 10 | 0 | 10 |
| DSCC1 | CPNE8 | 0.772189 | 4 | 0 | 3 |
| DSCC1 | LIN9 | 0.771841 | 6 | 0 | 6 |
| DSCC1 | WDR5 | 0.771796 | 5 | 0 | 5 |
| DSCC1 | ZNF680 | 0.771097 | 3 | 0 | 3 |
| DSCC1 | BUB1 | 0.770764 | 9 | 0 | 8 |
| DSCC1 | NUF2 | 0.769532 | 7 | 0 | 7 |
| DSCC1 | GEN1 | 0.768116 | 4 | 0 | 4 |
| DSCC1 | ATAD2 | 0.766356 | 11 | 0 | 10 |
| DSCC1 | ECT2 | 0.766287 | 10 | 0 | 10 |
| DSCC1 | MASTL | 0.765745 | 6 | 0 | 6 |
| DSCC1 | EXO1 | 0.765209 | 10 | 0 | 10 |
| DSCC1 | NOM1 | 0.764829 | 4 | 0 | 4 |
For details and further investigation, click here
