| Full name: NIMA related kinase 2 | Alias Symbol: NLK1|NEK2A|RP67|PPP1R111 | ||
| Type: protein-coding gene | Cytoband: 1q32.3 | ||
| Entrez ID: 4751 | HGNC ID: HGNC:7745 | Ensembl Gene: ENSG00000117650 | OMIM ID: 604043 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NEK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEK2 | 4751 | 204641_at | 1.9614 | 0.0140 | |
| GSE20347 | NEK2 | 4751 | 204641_at | 1.8641 | 0.0000 | |
| GSE23400 | NEK2 | 4751 | 204641_at | 1.4121 | 0.0000 | |
| GSE26886 | NEK2 | 4751 | 204641_at | 0.4821 | 0.1631 | |
| GSE29001 | NEK2 | 4751 | 204641_at | 2.0059 | 0.0000 | |
| GSE38129 | NEK2 | 4751 | 204641_at | 2.3596 | 0.0000 | |
| GSE45670 | NEK2 | 4751 | 204641_at | 1.8326 | 0.0000 | |
| GSE53622 | NEK2 | 4751 | 22803 | 1.8517 | 0.0000 | |
| GSE53624 | NEK2 | 4751 | 22803 | 2.0825 | 0.0000 | |
| GSE63941 | NEK2 | 4751 | 204641_at | 3.7675 | 0.0000 | |
| GSE77861 | NEK2 | 4751 | 204641_at | 1.1572 | 0.0083 | |
| GSE97050 | NEK2 | 4751 | A_23_P35219 | 1.7411 | 0.1297 | |
| SRP007169 | NEK2 | 4751 | RNAseq | 3.0308 | 0.0000 | |
| SRP064894 | NEK2 | 4751 | RNAseq | 1.3907 | 0.0000 | |
| SRP133303 | NEK2 | 4751 | RNAseq | 1.4974 | 0.0000 | |
| SRP159526 | NEK2 | 4751 | RNAseq | 1.5934 | 0.0008 | |
| SRP193095 | NEK2 | 4751 | RNAseq | 1.0905 | 0.0000 | |
| SRP219564 | NEK2 | 4751 | RNAseq | 1.1119 | 0.1087 | |
| TCGA | NEK2 | 4751 | RNAseq | 1.6227 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by NEK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEK2 | 4751 | 11 | 0 | 19 | |
| GSE20123 | NEK2 | 4751 | 10 | 0 | 20 | |
| GSE43470 | NEK2 | 4751 | 7 | 0 | 36 | |
| GSE46452 | NEK2 | 4751 | 3 | 1 | 55 | |
| GSE47630 | NEK2 | 4751 | 15 | 0 | 25 | |
| GSE54993 | NEK2 | 4751 | 0 | 6 | 64 | |
| GSE54994 | NEK2 | 4751 | 13 | 0 | 40 | |
| GSE60625 | NEK2 | 4751 | 0 | 0 | 11 | |
| GSE74703 | NEK2 | 4751 | 7 | 0 | 29 | |
| GSE74704 | NEK2 | 4751 | 4 | 0 | 16 | |
| TCGA | NEK2 | 4751 | 45 | 3 | 48 |
Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.
Somatic mutations of NEK2:
Generating mutation plots.
Highly correlated genes for NEK2:
Showing top 20/2151 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEK2 | CENPF | 0.895736 | 13 | 0 | 13 |
| NEK2 | TOP2A | 0.883133 | 13 | 0 | 13 |
| NEK2 | ASPM | 0.882389 | 13 | 0 | 13 |
| NEK2 | NUF2 | 0.880422 | 9 | 0 | 9 |
| NEK2 | KIF14 | 0.877419 | 13 | 0 | 13 |
| NEK2 | CEP55 | 0.86981 | 13 | 0 | 13 |
| NEK2 | DTL | 0.867505 | 13 | 0 | 13 |
| NEK2 | UBE2C | 0.859309 | 13 | 0 | 13 |
| NEK2 | CDK1 | 0.857985 | 12 | 0 | 12 |
| NEK2 | TPX2 | 0.857555 | 13 | 0 | 12 |
| NEK2 | RAD51AP1 | 0.853549 | 13 | 0 | 13 |
| NEK2 | KIF20A | 0.853465 | 13 | 0 | 13 |
| NEK2 | NUSAP1 | 0.851731 | 13 | 0 | 13 |
| NEK2 | NCAPH | 0.845592 | 9 | 0 | 9 |
| NEK2 | PRC1 | 0.844425 | 13 | 0 | 13 |
| NEK2 | BUB1B | 0.843254 | 10 | 0 | 9 |
| NEK2 | CCNB2 | 0.842586 | 12 | 0 | 12 |
| NEK2 | BUB1 | 0.842367 | 11 | 0 | 11 |
| NEK2 | GINS1 | 0.840115 | 12 | 0 | 12 |
| NEK2 | TTK | 0.838487 | 13 | 0 | 13 |
For details and further investigation, click here
