STIL

 

Full name: STIL centriolar assembly protein Alias Symbol: MCPH7
Type: protein-coding gene Cytoband: 1p33
Entrez ID: 6491 HGNC ID: HGNC:10879 Ensembl Gene: ENSG00000123473 OMIM ID: 181590
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of STIL:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 STIL 6491 205339_at 1.4773 0.0494
GSE20347 STIL 6491 205339_at 1.5146 0.0000
GSE23400 STIL 6491 205339_at 0.7973 0.0000
GSE26886 STIL 6491 205339_at 0.7540 0.0087
GSE29001 STIL 6491 205339_at 1.4152 0.0000
GSE38129 STIL 6491 205339_at 1.8529 0.0000
GSE45670 STIL 6491 205339_at 1.4339 0.0000
GSE53622 STIL 6491 38010 1.8792 0.0000
GSE53624 STIL 6491 38010 1.7228 0.0000
GSE63941 STIL 6491 205339_at 2.2989 0.0002
GSE77861 STIL 6491 205339_at 0.5369 0.0999
GSE97050 STIL 6491 A_33_P3400477 1.7704 0.1298
SRP007169 STIL 6491 RNAseq 2.3307 0.0000
SRP008496 STIL 6491 RNAseq 1.5422 0.0000
SRP064894 STIL 6491 RNAseq 1.1245 0.0000
SRP133303 STIL 6491 RNAseq 1.6793 0.0000
SRP159526 STIL 6491 RNAseq 1.1485 0.0000
SRP193095 STIL 6491 RNAseq 1.2646 0.0000
SRP219564 STIL 6491 RNAseq 1.6508 0.0148
TCGA STIL 6491 RNAseq 0.9814 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by STIL expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of STIL:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 STIL 6491 4 3 23
GSE20123 STIL 6491 4 2 24
GSE43470 STIL 6491 5 1 37
GSE46452 STIL 6491 2 1 56
GSE47630 STIL 6491 8 4 28
GSE54993 STIL 6491 0 1 69
GSE54994 STIL 6491 11 2 40
GSE60625 STIL 6491 0 0 11
GSE74703 STIL 6491 4 1 31
GSE74704 STIL 6491 2 0 18
TCGA STIL 6491 10 17 69

Total number of gains: 50; Total number of losses: 32; Total Number of normals: 406.  

 

Somatic mutations of STIL:

 

Generating mutation plots.

 

Highly correlated genes for STIL:

 

Showing top 20/1875 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
STILKIF2C0.88061413013
STILCDK10.85815412012
STILTPX20.85737912012
STILKIF4A0.853511011
STILATAD20.83351812012
STILCDKN30.83010312012
STILMKI670.82917512012
STILFOXM10.82845612012
STILRAD51AP10.82822612012
STILKIF140.8269512012
STILTRIP130.82045312011
STILCKS1B0.8172312012
STILPLK10.81249210010
STILDLGAP50.81086213012
STILKIF20A0.80881913012
STILESCO20.808648606
STILWDHD10.80830912012
STILCEP550.80794713012
STILMELK0.80707512012
STILNEK20.80620213013

For details and further investigation, click here