| Full name: PDZ domain containing 8 | Alias Symbol: bA129M16.2|FLJ34427 | ||
| Type: protein-coding gene | Cytoband: 10q25.3-q26.11 | ||
| Entrez ID: 118987 | HGNC ID: HGNC:26974 | Ensembl Gene: ENSG00000165650 | OMIM ID: 614235 |
| Drug and gene relationship at DGIdb | |||
Expression of PDZD8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDZD8 | 118987 | 230416_at | -0.8243 | 0.1704 | |
| GSE20347 | PDZD8 | 118987 | 213549_at | -1.3278 | 0.0000 | |
| GSE23400 | PDZD8 | 118987 | 213549_at | -0.6323 | 0.0000 | |
| GSE26886 | PDZD8 | 118987 | 213549_at | -0.1713 | 0.6277 | |
| GSE29001 | PDZD8 | 118987 | 213549_at | -1.0699 | 0.0065 | |
| GSE38129 | PDZD8 | 118987 | 213549_at | -0.9090 | 0.0000 | |
| GSE45670 | PDZD8 | 118987 | 230416_at | -0.8040 | 0.0003 | |
| GSE53622 | PDZD8 | 118987 | 157736 | -0.7366 | 0.0000 | |
| GSE53624 | PDZD8 | 118987 | 157736 | -0.6885 | 0.0000 | |
| GSE63941 | PDZD8 | 118987 | 230416_at | 0.0614 | 0.9019 | |
| GSE77861 | PDZD8 | 118987 | 213549_at | -1.0579 | 0.0047 | |
| GSE97050 | PDZD8 | 118987 | A_23_P321452 | -0.1403 | 0.7792 | |
| SRP007169 | PDZD8 | 118987 | RNAseq | -1.6144 | 0.0015 | |
| SRP008496 | PDZD8 | 118987 | RNAseq | -1.3241 | 0.0000 | |
| SRP064894 | PDZD8 | 118987 | RNAseq | -1.1403 | 0.0000 | |
| SRP133303 | PDZD8 | 118987 | RNAseq | -0.4457 | 0.0020 | |
| SRP159526 | PDZD8 | 118987 | RNAseq | -0.7313 | 0.0750 | |
| SRP193095 | PDZD8 | 118987 | RNAseq | -0.6934 | 0.0000 | |
| SRP219564 | PDZD8 | 118987 | RNAseq | -0.7083 | 0.0478 | |
| TCGA | PDZD8 | 118987 | RNAseq | -0.2298 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by PDZD8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDZD8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDZD8 | 118987 | 1 | 7 | 22 | |
| GSE20123 | PDZD8 | 118987 | 1 | 7 | 22 | |
| GSE43470 | PDZD8 | 118987 | 0 | 9 | 34 | |
| GSE46452 | PDZD8 | 118987 | 0 | 11 | 48 | |
| GSE47630 | PDZD8 | 118987 | 2 | 14 | 24 | |
| GSE54993 | PDZD8 | 118987 | 8 | 0 | 62 | |
| GSE54994 | PDZD8 | 118987 | 1 | 9 | 43 | |
| GSE60625 | PDZD8 | 118987 | 0 | 0 | 11 | |
| GSE74703 | PDZD8 | 118987 | 0 | 6 | 30 | |
| GSE74704 | PDZD8 | 118987 | 1 | 3 | 16 | |
| TCGA | PDZD8 | 118987 | 4 | 28 | 64 |
Total number of gains: 18; Total number of losses: 94; Total Number of normals: 376.
Somatic mutations of PDZD8:
Generating mutation plots.
Highly correlated genes for PDZD8:
Showing top 20/1559 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDZD8 | RBM20 | 0.797708 | 3 | 0 | 3 |
| PDZD8 | MPP7 | 0.776569 | 6 | 0 | 6 |
| PDZD8 | INTS12 | 0.774235 | 3 | 0 | 3 |
| PDZD8 | CCNYL1 | 0.759817 | 4 | 0 | 4 |
| PDZD8 | WDR36 | 0.755438 | 3 | 0 | 3 |
| PDZD8 | EPG5 | 0.749302 | 3 | 0 | 3 |
| PDZD8 | SLC46A2 | 0.743931 | 6 | 0 | 6 |
| PDZD8 | TCHP | 0.742296 | 3 | 0 | 3 |
| PDZD8 | BRK1 | 0.74025 | 6 | 0 | 6 |
| PDZD8 | MTPN | 0.737702 | 6 | 0 | 6 |
| PDZD8 | LSM11 | 0.735751 | 4 | 0 | 3 |
| PDZD8 | TMEM234 | 0.734166 | 3 | 0 | 3 |
| PDZD8 | BLNK | 0.730891 | 10 | 0 | 10 |
| PDZD8 | CAPN14 | 0.730259 | 5 | 0 | 5 |
| PDZD8 | SFTA2 | 0.729238 | 3 | 0 | 3 |
| PDZD8 | MITD1 | 0.729203 | 3 | 0 | 3 |
| PDZD8 | SPAG17 | 0.725663 | 3 | 0 | 3 |
| PDZD8 | CAPNS2 | 0.722926 | 4 | 0 | 4 |
| PDZD8 | A2ML1 | 0.722325 | 5 | 0 | 5 |
| PDZD8 | ZNF70 | 0.721482 | 3 | 0 | 3 |
For details and further investigation, click here
