| Full name: egl-9 family hypoxia inducible factor 3 | Alias Symbol: PHD3|HIFPH3 | ||
| Type: protein-coding gene | Cytoband: 14q13.1 | ||
| Entrez ID: 112399 | HGNC ID: HGNC:14661 | Ensembl Gene: ENSG00000129521 | OMIM ID: 606426 |
| Drug and gene relationship at DGIdb | |||
EGLN3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa05200 | Pathways in cancer | |
| hsa05211 | Renal cell carcinoma |
Expression of EGLN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EGLN3 | 112399 | 222847_s_at | -0.5436 | 0.6806 | |
| GSE20347 | EGLN3 | 112399 | 219232_s_at | 0.4365 | 0.2066 | |
| GSE23400 | EGLN3 | 112399 | 219232_s_at | 0.1792 | 0.0602 | |
| GSE26886 | EGLN3 | 112399 | 222847_s_at | -0.6168 | 0.3014 | |
| GSE29001 | EGLN3 | 112399 | 219232_s_at | -0.1705 | 0.8240 | |
| GSE38129 | EGLN3 | 112399 | 219232_s_at | 0.3991 | 0.1582 | |
| GSE45670 | EGLN3 | 112399 | 222847_s_at | 0.8153 | 0.0972 | |
| GSE63941 | EGLN3 | 112399 | 222847_s_at | 1.8758 | 0.0954 | |
| GSE77861 | EGLN3 | 112399 | 222847_s_at | 0.1307 | 0.8815 | |
| GSE97050 | EGLN3 | 112399 | A_33_P3256952 | 0.2289 | 0.7701 | |
| SRP007169 | EGLN3 | 112399 | RNAseq | -0.8244 | 0.1824 | |
| SRP008496 | EGLN3 | 112399 | RNAseq | -1.6052 | 0.0003 | |
| SRP064894 | EGLN3 | 112399 | RNAseq | 0.3847 | 0.3443 | |
| SRP133303 | EGLN3 | 112399 | RNAseq | 1.1524 | 0.0005 | |
| SRP159526 | EGLN3 | 112399 | RNAseq | -1.6865 | 0.0007 | |
| SRP193095 | EGLN3 | 112399 | RNAseq | -0.6303 | 0.0717 | |
| SRP219564 | EGLN3 | 112399 | RNAseq | -1.1155 | 0.0306 | |
| TCGA | EGLN3 | 112399 | RNAseq | -0.0389 | 0.8282 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by EGLN3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of EGLN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EGLN3 | 112399 | 10 | 4 | 16 | |
| GSE20123 | EGLN3 | 112399 | 11 | 4 | 15 | |
| GSE43470 | EGLN3 | 112399 | 9 | 2 | 32 | |
| GSE46452 | EGLN3 | 112399 | 18 | 2 | 39 | |
| GSE47630 | EGLN3 | 112399 | 11 | 10 | 19 | |
| GSE54993 | EGLN3 | 112399 | 3 | 11 | 56 | |
| GSE54994 | EGLN3 | 112399 | 19 | 5 | 29 | |
| GSE60625 | EGLN3 | 112399 | 0 | 2 | 9 | |
| GSE74703 | EGLN3 | 112399 | 8 | 2 | 26 | |
| GSE74704 | EGLN3 | 112399 | 5 | 3 | 12 | |
| TCGA | EGLN3 | 112399 | 34 | 14 | 48 |
Total number of gains: 128; Total number of losses: 59; Total Number of normals: 301.
Somatic mutations of EGLN3:
Generating mutation plots.
Highly correlated genes for EGLN3:
Showing top 20/74 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EGLN3 | UBE2D2 | 0.705767 | 3 | 0 | 3 |
| EGLN3 | DDX46 | 0.65757 | 3 | 0 | 3 |
| EGLN3 | NEMF | 0.651711 | 3 | 0 | 3 |
| EGLN3 | FBXW11 | 0.643164 | 3 | 0 | 3 |
| EGLN3 | ARFGAP3 | 0.641953 | 3 | 0 | 3 |
| EGLN3 | PAPPA | 0.618698 | 3 | 0 | 3 |
| EGLN3 | RNF187 | 0.617599 | 3 | 0 | 3 |
| EGLN3 | BRMS1L | 0.605289 | 3 | 0 | 3 |
| EGLN3 | TBC1D20 | 0.604462 | 3 | 0 | 3 |
| EGLN3 | TNFSF9 | 0.600896 | 3 | 0 | 3 |
| EGLN3 | NUBPL | 0.59933 | 4 | 0 | 3 |
| EGLN3 | SEC24B | 0.593249 | 3 | 0 | 3 |
| EGLN3 | RLF | 0.592885 | 6 | 0 | 6 |
| EGLN3 | EAPP | 0.58391 | 4 | 0 | 3 |
| EGLN3 | SORBS2 | 0.583831 | 3 | 0 | 3 |
| EGLN3 | SEC61G | 0.581405 | 4 | 0 | 3 |
| EGLN3 | SLU7 | 0.581319 | 3 | 0 | 3 |
| EGLN3 | STEAP4 | 0.58035 | 4 | 0 | 3 |
| EGLN3 | ZBTB38 | 0.578693 | 3 | 0 | 3 |
| EGLN3 | EGLN2 | 0.578106 | 3 | 0 | 3 |
For details and further investigation, click here
