| Full name: pleckstrin homology and RhoGEF domain containing G1 | Alias Symbol: KIAA1209|ARHGEF41 | ||
| Type: protein-coding gene | Cytoband: 6q25.1 | ||
| Entrez ID: 57480 | HGNC ID: HGNC:20884 | Ensembl Gene: ENSG00000120278 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHG1 | 57480 | 226122_at | -0.0474 | 0.9722 | |
| GSE26886 | PLEKHG1 | 57480 | 226122_at | -1.6727 | 0.0001 | |
| GSE45670 | PLEKHG1 | 57480 | 226122_at | -0.0297 | 0.9253 | |
| GSE53622 | PLEKHG1 | 57480 | 43330 | -0.6054 | 0.0000 | |
| GSE53624 | PLEKHG1 | 57480 | 11049 | -0.3250 | 0.0036 | |
| GSE63941 | PLEKHG1 | 57480 | 226122_at | -0.3630 | 0.7973 | |
| GSE77861 | PLEKHG1 | 57480 | 226122_at | 0.9247 | 0.0025 | |
| GSE97050 | PLEKHG1 | 57480 | A_33_P3367471 | 0.3644 | 0.3859 | |
| SRP007169 | PLEKHG1 | 57480 | RNAseq | -0.1737 | 0.6750 | |
| SRP008496 | PLEKHG1 | 57480 | RNAseq | -0.2645 | 0.3096 | |
| SRP064894 | PLEKHG1 | 57480 | RNAseq | -0.4079 | 0.1221 | |
| SRP133303 | PLEKHG1 | 57480 | RNAseq | -0.1284 | 0.4931 | |
| SRP159526 | PLEKHG1 | 57480 | RNAseq | -0.5564 | 0.1617 | |
| SRP193095 | PLEKHG1 | 57480 | RNAseq | -0.1434 | 0.3513 | |
| SRP219564 | PLEKHG1 | 57480 | RNAseq | -0.1806 | 0.6689 | |
| TCGA | PLEKHG1 | 57480 | RNAseq | -0.0576 | 0.5679 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PLEKHG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHG1 | 57480 | 2 | 4 | 24 | |
| GSE20123 | PLEKHG1 | 57480 | 1 | 3 | 26 | |
| GSE43470 | PLEKHG1 | 57480 | 4 | 0 | 39 | |
| GSE46452 | PLEKHG1 | 57480 | 3 | 10 | 46 | |
| GSE47630 | PLEKHG1 | 57480 | 9 | 4 | 27 | |
| GSE54993 | PLEKHG1 | 57480 | 3 | 2 | 65 | |
| GSE54994 | PLEKHG1 | 57480 | 8 | 8 | 37 | |
| GSE60625 | PLEKHG1 | 57480 | 0 | 1 | 10 | |
| GSE74703 | PLEKHG1 | 57480 | 4 | 0 | 32 | |
| GSE74704 | PLEKHG1 | 57480 | 0 | 1 | 19 | |
| TCGA | PLEKHG1 | 57480 | 12 | 20 | 64 |
Total number of gains: 46; Total number of losses: 53; Total Number of normals: 389.
Somatic mutations of PLEKHG1:
Generating mutation plots.
Highly correlated genes for PLEKHG1:
Showing top 20/197 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHG1 | INO80D | 0.79847 | 3 | 0 | 3 |
| PLEKHG1 | CYB561 | 0.796104 | 3 | 0 | 3 |
| PLEKHG1 | MAPK6 | 0.78726 | 3 | 0 | 3 |
| PLEKHG1 | MAGT1 | 0.774376 | 3 | 0 | 3 |
| PLEKHG1 | DUSP16 | 0.756274 | 3 | 0 | 3 |
| PLEKHG1 | GTF3C2 | 0.751142 | 3 | 0 | 3 |
| PLEKHG1 | RBAK | 0.740008 | 3 | 0 | 3 |
| PLEKHG1 | EPG5 | 0.739323 | 3 | 0 | 3 |
| PLEKHG1 | SMC5 | 0.736853 | 3 | 0 | 3 |
| PLEKHG1 | PLEKHM1 | 0.73519 | 4 | 0 | 4 |
| PLEKHG1 | PCK2 | 0.725907 | 3 | 0 | 3 |
| PLEKHG1 | RAD23B | 0.72571 | 3 | 0 | 3 |
| PLEKHG1 | CCDC7 | 0.723664 | 3 | 0 | 3 |
| PLEKHG1 | CCDC117 | 0.723101 | 3 | 0 | 3 |
| PLEKHG1 | CBLC | 0.722637 | 3 | 0 | 3 |
| PLEKHG1 | ASNSD1 | 0.720699 | 3 | 0 | 3 |
| PLEKHG1 | EAF1 | 0.71931 | 3 | 0 | 3 |
| PLEKHG1 | EXOSC6 | 0.71732 | 3 | 0 | 3 |
| PLEKHG1 | NAA25 | 0.714939 | 3 | 0 | 3 |
| PLEKHG1 | SFPQ | 0.710929 | 3 | 0 | 3 |
For details and further investigation, click here
