| Full name: RAD17 checkpoint clamp loader component | Alias Symbol: Rad24|RAD17Sp|CCYC | ||
| Type: protein-coding gene | Cytoband: 5q13.2 | ||
| Entrez ID: 5884 | HGNC ID: HGNC:9807 | Ensembl Gene: ENSG00000152942 | OMIM ID: 603139 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RAD17:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAD17 | 5884 | 207405_s_at | 0.0676 | 0.9129 | |
| GSE20347 | RAD17 | 5884 | 207405_s_at | -0.1533 | 0.2334 | |
| GSE23400 | RAD17 | 5884 | 210826_x_at | -0.0699 | 0.1097 | |
| GSE26886 | RAD17 | 5884 | 207405_s_at | -0.1991 | 0.4821 | |
| GSE29001 | RAD17 | 5884 | 207405_s_at | 0.1573 | 0.5040 | |
| GSE38129 | RAD17 | 5884 | 207405_s_at | -0.0097 | 0.9438 | |
| GSE45670 | RAD17 | 5884 | 207405_s_at | 0.0563 | 0.7172 | |
| GSE53622 | RAD17 | 5884 | 86490 | -0.0044 | 0.9574 | |
| GSE53624 | RAD17 | 5884 | 86490 | -0.0964 | 0.4604 | |
| GSE63941 | RAD17 | 5884 | 207405_s_at | -0.5492 | 0.2254 | |
| GSE77861 | RAD17 | 5884 | 207405_s_at | -0.2767 | 0.2390 | |
| GSE97050 | RAD17 | 5884 | A_24_P97836 | 0.4126 | 0.1867 | |
| SRP007169 | RAD17 | 5884 | RNAseq | 0.4660 | 0.2696 | |
| SRP008496 | RAD17 | 5884 | RNAseq | 0.4509 | 0.1271 | |
| SRP064894 | RAD17 | 5884 | RNAseq | -0.0731 | 0.6583 | |
| SRP133303 | RAD17 | 5884 | RNAseq | 0.1393 | 0.2350 | |
| SRP159526 | RAD17 | 5884 | RNAseq | 0.0394 | 0.8651 | |
| SRP193095 | RAD17 | 5884 | RNAseq | -0.3582 | 0.0000 | |
| SRP219564 | RAD17 | 5884 | RNAseq | -0.2167 | 0.3036 | |
| TCGA | RAD17 | 5884 | RNAseq | -0.0931 | 0.0752 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RAD17 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAD17:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAD17 | 5884 | 1 | 13 | 16 | |
| GSE20123 | RAD17 | 5884 | 1 | 13 | 16 | |
| GSE43470 | RAD17 | 5884 | 1 | 12 | 30 | |
| GSE46452 | RAD17 | 5884 | 0 | 28 | 31 | |
| GSE47630 | RAD17 | 5884 | 2 | 17 | 21 | |
| GSE54993 | RAD17 | 5884 | 8 | 1 | 61 | |
| GSE54994 | RAD17 | 5884 | 1 | 21 | 31 | |
| GSE60625 | RAD17 | 5884 | 0 | 0 | 11 | |
| GSE74703 | RAD17 | 5884 | 1 | 9 | 26 | |
| GSE74704 | RAD17 | 5884 | 1 | 6 | 13 | |
| TCGA | RAD17 | 5884 | 4 | 51 | 41 |
Total number of gains: 20; Total number of losses: 171; Total Number of normals: 297.
Somatic mutations of RAD17:
Generating mutation plots.
Highly correlated genes for RAD17:
Showing top 20/599 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAD17 | FBXL3 | 0.878368 | 3 | 0 | 3 |
| RAD17 | NUDT15 | 0.829932 | 3 | 0 | 3 |
| RAD17 | DECR1 | 0.799108 | 4 | 0 | 4 |
| RAD17 | TMOD2 | 0.775949 | 3 | 0 | 3 |
| RAD17 | SNW1 | 0.770931 | 3 | 0 | 3 |
| RAD17 | LYPLAL1 | 0.759972 | 3 | 0 | 3 |
| RAD17 | VPS36 | 0.756008 | 3 | 0 | 3 |
| RAD17 | SCAF8 | 0.755915 | 3 | 0 | 3 |
| RAD17 | MRPL19 | 0.742805 | 3 | 0 | 3 |
| RAD17 | GTF2H3 | 0.74025 | 4 | 0 | 4 |
| RAD17 | P2RX7 | 0.739126 | 3 | 0 | 3 |
| RAD17 | ASCC3 | 0.735114 | 4 | 0 | 4 |
| RAD17 | CD2AP | 0.732151 | 4 | 0 | 4 |
| RAD17 | ROBO1 | 0.731654 | 4 | 0 | 4 |
| RAD17 | MTIF3 | 0.731302 | 3 | 0 | 3 |
| RAD17 | QKI | 0.724593 | 3 | 0 | 3 |
| RAD17 | C8orf76 | 0.722662 | 3 | 0 | 3 |
| RAD17 | TPRG1L | 0.721729 | 3 | 0 | 3 |
| RAD17 | TTC8 | 0.719569 | 3 | 0 | 3 |
| RAD17 | GTF2F2 | 0.717568 | 3 | 0 | 3 |
For details and further investigation, click here
