| Full name: leucyl and cystinyl aminopeptidase | Alias Symbol: CAP|PLAP|P-LAP|IRAP | ||
| Type: protein-coding gene | Cytoband: 5q15 | ||
| Entrez ID: 4012 | HGNC ID: HGNC:6656 | Ensembl Gene: ENSG00000113441 | OMIM ID: 151300 |
| Drug and gene relationship at DGIdb | |||
Expression of LNPEP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LNPEP | 4012 | 225176_at | -0.7357 | 0.0271 | |
| GSE20347 | LNPEP | 4012 | 207904_s_at | -0.1941 | 0.0350 | |
| GSE23400 | LNPEP | 4012 | 207904_s_at | -0.0519 | 0.1506 | |
| GSE26886 | LNPEP | 4012 | 225176_at | -0.2608 | 0.3095 | |
| GSE29001 | LNPEP | 4012 | 207904_s_at | -0.0388 | 0.8694 | |
| GSE38129 | LNPEP | 4012 | 207904_s_at | -0.0259 | 0.8259 | |
| GSE45670 | LNPEP | 4012 | 225176_at | -0.5363 | 0.0245 | |
| GSE53622 | LNPEP | 4012 | 102575 | -0.6591 | 0.0000 | |
| GSE53624 | LNPEP | 4012 | 37030 | -0.8239 | 0.0000 | |
| GSE63941 | LNPEP | 4012 | 225176_at | -1.0379 | 0.0405 | |
| GSE77861 | LNPEP | 4012 | 225176_at | -0.8137 | 0.0075 | |
| GSE97050 | LNPEP | 4012 | A_23_P156061 | -0.2994 | 0.3126 | |
| SRP007169 | LNPEP | 4012 | RNAseq | -1.0891 | 0.0022 | |
| SRP008496 | LNPEP | 4012 | RNAseq | -0.9101 | 0.0000 | |
| SRP064894 | LNPEP | 4012 | RNAseq | -0.5670 | 0.0076 | |
| SRP133303 | LNPEP | 4012 | RNAseq | -0.2649 | 0.1558 | |
| SRP159526 | LNPEP | 4012 | RNAseq | -0.9016 | 0.0215 | |
| SRP193095 | LNPEP | 4012 | RNAseq | -0.8286 | 0.0000 | |
| SRP219564 | LNPEP | 4012 | RNAseq | -0.8420 | 0.0109 | |
| TCGA | LNPEP | 4012 | RNAseq | -0.2230 | 0.0066 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by LNPEP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LNPEP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LNPEP | 4012 | 1 | 13 | 16 | |
| GSE20123 | LNPEP | 4012 | 1 | 13 | 16 | |
| GSE43470 | LNPEP | 4012 | 3 | 9 | 31 | |
| GSE46452 | LNPEP | 4012 | 0 | 28 | 31 | |
| GSE47630 | LNPEP | 4012 | 0 | 20 | 20 | |
| GSE54993 | LNPEP | 4012 | 8 | 1 | 61 | |
| GSE54994 | LNPEP | 4012 | 1 | 18 | 34 | |
| GSE60625 | LNPEP | 4012 | 0 | 0 | 11 | |
| GSE74703 | LNPEP | 4012 | 2 | 7 | 27 | |
| GSE74704 | LNPEP | 4012 | 1 | 7 | 12 | |
| TCGA | LNPEP | 4012 | 3 | 43 | 50 |
Total number of gains: 20; Total number of losses: 159; Total Number of normals: 309.
Somatic mutations of LNPEP:
Generating mutation plots.
Highly correlated genes for LNPEP:
Showing top 20/1222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LNPEP | CDC16 | 0.77686 | 3 | 0 | 3 |
| LNPEP | GPBP1 | 0.757281 | 4 | 0 | 4 |
| LNPEP | ELL3 | 0.737309 | 3 | 0 | 3 |
| LNPEP | NCKAP1 | 0.736424 | 4 | 0 | 4 |
| LNPEP | GCC2 | 0.736194 | 3 | 0 | 3 |
| LNPEP | HEMK1 | 0.732539 | 4 | 0 | 4 |
| LNPEP | APOB | 0.729847 | 3 | 0 | 3 |
| LNPEP | BCAS2 | 0.729321 | 3 | 0 | 3 |
| LNPEP | DEF8 | 0.72747 | 3 | 0 | 3 |
| LNPEP | RHOBTB3 | 0.721364 | 3 | 0 | 3 |
| LNPEP | CDC40 | 0.716708 | 3 | 0 | 3 |
| LNPEP | MRPS36 | 0.709 | 7 | 0 | 7 |
| LNPEP | SRR | 0.703292 | 4 | 0 | 3 |
| LNPEP | KDM5D | 0.702747 | 4 | 0 | 4 |
| LNPEP | PLEKHA2 | 0.699714 | 3 | 0 | 3 |
| LNPEP | ARL6IP5 | 0.699226 | 8 | 0 | 8 |
| LNPEP | APOLD1 | 0.698588 | 4 | 0 | 4 |
| LNPEP | COMMD6 | 0.698405 | 3 | 0 | 3 |
| LNPEP | DENND4C | 0.697722 | 8 | 0 | 6 |
| LNPEP | SNORA68 | 0.697157 | 3 | 0 | 3 |
For details and further investigation, click here
