| Full name: defensin beta 119 | Alias Symbol: DEFB-19|DEFB-20 | ||
| Type: protein-coding gene | Cytoband: 20q11.21 | ||
| Entrez ID: 245932 | HGNC ID: HGNC:18099 | Ensembl Gene: ENSG00000180483 | OMIM ID: 615997 |
| Drug and gene relationship at DGIdb | |||
Expression of DEFB119:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEFB119 | 245932 | 231155_at | -0.0728 | 0.8089 | |
| GSE26886 | DEFB119 | 245932 | 231155_at | -0.0116 | 0.9366 | |
| GSE45670 | DEFB119 | 245932 | 1553093_a_at | 0.0376 | 0.5493 | |
| GSE53622 | DEFB119 | 245932 | 46175 | 0.0925 | 0.4000 | |
| GSE53624 | DEFB119 | 245932 | 46175 | 0.5053 | 0.0000 | |
| GSE63941 | DEFB119 | 245932 | 231155_at | 0.2539 | 0.0774 | |
| GSE77861 | DEFB119 | 245932 | 1553093_a_at | -0.1837 | 0.0466 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEFB119 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEFB119:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEFB119 | 245932 | 14 | 0 | 16 | |
| GSE20123 | DEFB119 | 245932 | 14 | 0 | 16 | |
| GSE43470 | DEFB119 | 245932 | 11 | 0 | 32 | |
| GSE46452 | DEFB119 | 245932 | 29 | 0 | 30 | |
| GSE47630 | DEFB119 | 245932 | 24 | 0 | 16 | |
| GSE54993 | DEFB119 | 245932 | 0 | 17 | 53 | |
| GSE54994 | DEFB119 | 245932 | 27 | 1 | 25 | |
| GSE60625 | DEFB119 | 245932 | 0 | 0 | 11 | |
| GSE74703 | DEFB119 | 245932 | 10 | 0 | 26 | |
| GSE74704 | DEFB119 | 245932 | 9 | 0 | 11 | |
| TCGA | DEFB119 | 245932 | 49 | 1 | 46 |
Total number of gains: 187; Total number of losses: 19; Total Number of normals: 282.
Somatic mutations of DEFB119:
Generating mutation plots.
Highly correlated genes for DEFB119:
Showing top 20/43 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEFB119 | TYSND1 | 0.757478 | 3 | 0 | 3 |
| DEFB119 | TIGD3 | 0.688449 | 3 | 0 | 3 |
| DEFB119 | ERBB3 | 0.687807 | 3 | 0 | 3 |
| DEFB119 | DUOX1 | 0.667765 | 3 | 0 | 3 |
| DEFB119 | MRGPRX2 | 0.657959 | 3 | 0 | 3 |
| DEFB119 | EPHA1 | 0.656509 | 3 | 0 | 3 |
| DEFB119 | KLF5 | 0.641897 | 3 | 0 | 3 |
| DEFB119 | ASL | 0.630964 | 3 | 0 | 3 |
| DEFB119 | DENND2C | 0.630713 | 3 | 0 | 3 |
| DEFB119 | TACSTD2 | 0.622367 | 3 | 0 | 3 |
| DEFB119 | GPR17 | 0.61575 | 3 | 0 | 3 |
| DEFB119 | LEMD1-AS1 | 0.614039 | 4 | 0 | 3 |
| DEFB119 | VGLL2 | 0.611337 | 4 | 0 | 3 |
| DEFB119 | SOX21-AS1 | 0.609099 | 3 | 0 | 3 |
| DEFB119 | ZNF554 | 0.607206 | 3 | 0 | 3 |
| DEFB119 | CRYBB3 | 0.601354 | 3 | 0 | 3 |
| DEFB119 | SCNN1A | 0.600999 | 3 | 0 | 3 |
| DEFB119 | TMBIM6 | 0.596552 | 3 | 0 | 3 |
| DEFB119 | SULT1C2 | 0.592229 | 4 | 0 | 3 |
| DEFB119 | RAPGEFL1 | 0.591651 | 3 | 0 | 3 |
For details and further investigation, click here
