| Full name: defensin beta 125 | Alias Symbol: DEFB-25 | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 245938 | HGNC ID: HGNC:18105 | Ensembl Gene: ENSG00000178591 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DEFB125:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEFB125 | 245938 | 1552998_at | -0.0931 | 0.7450 | |
| GSE26886 | DEFB125 | 245938 | 1552998_at | 0.0444 | 0.7073 | |
| GSE45670 | DEFB125 | 245938 | 1552998_at | 0.0395 | 0.6070 | |
| GSE53622 | DEFB125 | 245938 | 12076 | 0.3250 | 0.2198 | |
| GSE53624 | DEFB125 | 245938 | 12076 | 0.1978 | 0.0708 | |
| GSE63941 | DEFB125 | 245938 | 1552998_at | 0.0346 | 0.8402 | |
| GSE77861 | DEFB125 | 245938 | 1552998_at | 0.1474 | 0.0977 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEFB125 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEFB125:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEFB125 | 245938 | 12 | 4 | 14 | |
| GSE20123 | DEFB125 | 245938 | 13 | 4 | 13 | |
| GSE43470 | DEFB125 | 245938 | 10 | 2 | 31 | |
| GSE46452 | DEFB125 | 245938 | 26 | 1 | 32 | |
| GSE47630 | DEFB125 | 245938 | 19 | 4 | 17 | |
| GSE54993 | DEFB125 | 245938 | 2 | 15 | 53 | |
| GSE54994 | DEFB125 | 245938 | 24 | 2 | 27 | |
| GSE60625 | DEFB125 | 245938 | 0 | 0 | 11 | |
| GSE74703 | DEFB125 | 245938 | 9 | 2 | 25 | |
| GSE74704 | DEFB125 | 245938 | 8 | 2 | 10 | |
| TCGA | DEFB125 | 245938 | 41 | 11 | 44 |
Total number of gains: 164; Total number of losses: 47; Total Number of normals: 277.
Somatic mutations of DEFB125:
Generating mutation plots.
Highly correlated genes for DEFB125:
Showing top 20/25 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEFB125 | BAALC | 0.650641 | 3 | 0 | 3 |
| DEFB125 | CLRN3 | 0.648416 | 3 | 0 | 3 |
| DEFB125 | SEMA3G | 0.612265 | 3 | 0 | 3 |
| DEFB125 | KLHL41 | 0.597153 | 4 | 0 | 3 |
| DEFB125 | LINC01233 | 0.596609 | 4 | 0 | 3 |
| DEFB125 | PRODH2 | 0.589302 | 4 | 0 | 3 |
| DEFB125 | PRSS58 | 0.588622 | 4 | 0 | 3 |
| DEFB125 | C14orf178 | 0.588063 | 4 | 0 | 3 |
| DEFB125 | F2RL3 | 0.583902 | 3 | 0 | 3 |
| DEFB125 | NYAP2 | 0.578668 | 4 | 0 | 3 |
| DEFB125 | JAKMIP3 | 0.572431 | 4 | 0 | 3 |
| DEFB125 | ACR | 0.567512 | 3 | 0 | 3 |
| DEFB125 | HTR1A | 0.5544 | 3 | 0 | 3 |
| DEFB125 | LY6G5C | 0.551495 | 4 | 0 | 3 |
| DEFB125 | SSPO | 0.540517 | 4 | 0 | 3 |
| DEFB125 | HOXB1 | 0.53752 | 4 | 0 | 3 |
| DEFB125 | MMP21 | 0.534617 | 4 | 0 | 3 |
| DEFB125 | LINC00454 | 0.531397 | 5 | 0 | 3 |
| DEFB125 | KIR3DL1 | 0.531091 | 4 | 0 | 3 |
| DEFB125 | USP2-AS1 | 0.529541 | 4 | 0 | 3 |
For details and further investigation, click here
