| Full name: 5-hydroxytryptamine receptor 1A | Alias Symbol: 5-HT1A | ||
| Type: protein-coding gene | Cytoband: 5q12.3 | ||
| Entrez ID: 3350 | HGNC ID: HGNC:5286 | Ensembl Gene: ENSG00000178394 | OMIM ID: 109760 |
| Drug and gene relationship at DGIdb | |||
HTR1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04726 | Serotonergic synapse | |
| hsa04742 | Taste transduction |
Expression of HTR1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR1A | 3350 | 221351_at | -0.0946 | 0.7861 | |
| GSE20347 | HTR1A | 3350 | 221351_at | -0.0178 | 0.8252 | |
| GSE23400 | HTR1A | 3350 | 221351_at | -0.1037 | 0.0052 | |
| GSE26886 | HTR1A | 3350 | 221351_at | 0.0572 | 0.6036 | |
| GSE29001 | HTR1A | 3350 | 221351_at | 0.0265 | 0.8802 | |
| GSE38129 | HTR1A | 3350 | 221351_at | -0.1141 | 0.1087 | |
| GSE45670 | HTR1A | 3350 | 221351_at | 0.0359 | 0.6660 | |
| GSE53622 | HTR1A | 3350 | 156702 | 0.0214 | 0.8990 | |
| GSE53624 | HTR1A | 3350 | 156702 | 0.0555 | 0.6241 | |
| GSE63941 | HTR1A | 3350 | 221351_at | 0.0060 | 0.9776 | |
| GSE77861 | HTR1A | 3350 | 221351_at | -0.0626 | 0.6451 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HTR1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR1A | 3350 | 0 | 14 | 16 | |
| GSE20123 | HTR1A | 3350 | 0 | 14 | 16 | |
| GSE43470 | HTR1A | 3350 | 1 | 13 | 29 | |
| GSE46452 | HTR1A | 3350 | 0 | 28 | 31 | |
| GSE47630 | HTR1A | 3350 | 2 | 17 | 21 | |
| GSE54993 | HTR1A | 3350 | 8 | 1 | 61 | |
| GSE54994 | HTR1A | 3350 | 1 | 19 | 33 | |
| GSE60625 | HTR1A | 3350 | 0 | 0 | 11 | |
| GSE74703 | HTR1A | 3350 | 1 | 9 | 26 | |
| GSE74704 | HTR1A | 3350 | 0 | 7 | 13 | |
| TCGA | HTR1A | 3350 | 5 | 50 | 41 |
Total number of gains: 18; Total number of losses: 172; Total Number of normals: 298.
Somatic mutations of HTR1A:
Generating mutation plots.
Highly correlated genes for HTR1A:
Showing top 20/907 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR1A | ADCYAP1 | 0.741891 | 3 | 0 | 3 |
| HTR1A | SV2C | 0.719419 | 4 | 0 | 4 |
| HTR1A | CIITA | 0.710832 | 6 | 0 | 6 |
| HTR1A | TEKT2 | 0.707834 | 3 | 0 | 3 |
| HTR1A | SARDH | 0.702949 | 4 | 0 | 4 |
| HTR1A | MRPL41 | 0.699779 | 3 | 0 | 3 |
| HTR1A | KSR1 | 0.697283 | 4 | 0 | 4 |
| HTR1A | HUNK | 0.696886 | 3 | 0 | 3 |
| HTR1A | CST8 | 0.694618 | 4 | 0 | 4 |
| HTR1A | ATP8B3 | 0.691363 | 3 | 0 | 3 |
| HTR1A | KIAA0087 | 0.68709 | 3 | 0 | 3 |
| HTR1A | EPN1 | 0.673209 | 3 | 0 | 3 |
| HTR1A | WFDC8 | 0.667865 | 5 | 0 | 4 |
| HTR1A | TTR | 0.665882 | 5 | 0 | 4 |
| HTR1A | KIF25-AS1 | 0.664252 | 3 | 0 | 3 |
| HTR1A | SIX6 | 0.662418 | 5 | 0 | 5 |
| HTR1A | CGA | 0.658109 | 6 | 0 | 5 |
| HTR1A | CRYBB1 | 0.655903 | 6 | 0 | 6 |
| HTR1A | IRS4 | 0.655457 | 5 | 0 | 4 |
| HTR1A | UTF1 | 0.652492 | 4 | 0 | 4 |
For details and further investigation, click here
