| Full name: DENN domain containing 4A | Alias Symbol: IRLB | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 10260 | HGNC ID: HGNC:24321 | Ensembl Gene: ENSG00000174485 | OMIM ID: 600382 |
| Drug and gene relationship at DGIdb | |||
Expression of DENND4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DENND4A | 10260 | 1554352_s_at | 0.0839 | 0.8535 | |
| GSE20347 | DENND4A | 10260 | 214787_at | 0.4920 | 0.0100 | |
| GSE23400 | DENND4A | 10260 | 214787_at | 0.0751 | 0.1093 | |
| GSE26886 | DENND4A | 10260 | 1554352_s_at | 0.5445 | 0.0042 | |
| GSE29001 | DENND4A | 10260 | 214787_at | 0.1450 | 0.7706 | |
| GSE38129 | DENND4A | 10260 | 214787_at | 0.3377 | 0.0150 | |
| GSE45670 | DENND4A | 10260 | 1554352_s_at | -0.0230 | 0.9203 | |
| GSE53622 | DENND4A | 10260 | 81109 | -0.0942 | 0.3442 | |
| GSE53624 | DENND4A | 10260 | 81109 | -0.2507 | 0.0018 | |
| GSE63941 | DENND4A | 10260 | 1554352_s_at | -0.0214 | 0.9722 | |
| GSE77861 | DENND4A | 10260 | 1554352_s_at | 0.5509 | 0.0332 | |
| GSE97050 | DENND4A | 10260 | A_23_P384329 | -0.0332 | 0.9096 | |
| SRP007169 | DENND4A | 10260 | RNAseq | 0.8014 | 0.0344 | |
| SRP008496 | DENND4A | 10260 | RNAseq | 0.6933 | 0.0053 | |
| SRP064894 | DENND4A | 10260 | RNAseq | -0.1103 | 0.6248 | |
| SRP133303 | DENND4A | 10260 | RNAseq | 0.0466 | 0.7127 | |
| SRP159526 | DENND4A | 10260 | RNAseq | 0.2872 | 0.5529 | |
| SRP193095 | DENND4A | 10260 | RNAseq | 0.3071 | 0.0073 | |
| SRP219564 | DENND4A | 10260 | RNAseq | 0.0063 | 0.9811 | |
| TCGA | DENND4A | 10260 | RNAseq | -0.1293 | 0.0390 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DENND4A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DENND4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DENND4A | 10260 | 6 | 4 | 20 | |
| GSE20123 | DENND4A | 10260 | 6 | 4 | 20 | |
| GSE43470 | DENND4A | 10260 | 4 | 6 | 33 | |
| GSE46452 | DENND4A | 10260 | 3 | 7 | 49 | |
| GSE47630 | DENND4A | 10260 | 8 | 10 | 22 | |
| GSE54993 | DENND4A | 10260 | 5 | 6 | 59 | |
| GSE54994 | DENND4A | 10260 | 6 | 7 | 40 | |
| GSE60625 | DENND4A | 10260 | 4 | 0 | 7 | |
| GSE74703 | DENND4A | 10260 | 4 | 3 | 29 | |
| GSE74704 | DENND4A | 10260 | 3 | 3 | 14 | |
| TCGA | DENND4A | 10260 | 9 | 16 | 71 |
Total number of gains: 58; Total number of losses: 66; Total Number of normals: 364.
Somatic mutations of DENND4A:
Generating mutation plots.
Highly correlated genes for DENND4A:
Showing top 20/583 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DENND4A | MRPS11 | 0.770931 | 3 | 0 | 3 |
| DENND4A | IAH1 | 0.758532 | 3 | 0 | 3 |
| DENND4A | SFT2D3 | 0.715025 | 3 | 0 | 3 |
| DENND4A | SPPL2A | 0.71413 | 4 | 0 | 3 |
| DENND4A | FAM220A | 0.712877 | 3 | 0 | 3 |
| DENND4A | ZNF207 | 0.709021 | 3 | 0 | 3 |
| DENND4A | INPP4A | 0.705464 | 3 | 0 | 3 |
| DENND4A | SLC41A1 | 0.69531 | 3 | 0 | 3 |
| DENND4A | RYK | 0.683093 | 3 | 0 | 3 |
| DENND4A | FOPNL | 0.683084 | 3 | 0 | 3 |
| DENND4A | MRPL50 | 0.682017 | 3 | 0 | 3 |
| DENND4A | ZNF689 | 0.680968 | 3 | 0 | 3 |
| DENND4A | C2orf69 | 0.68042 | 4 | 0 | 4 |
| DENND4A | NPRL3 | 0.679829 | 3 | 0 | 3 |
| DENND4A | THAP5 | 0.668752 | 3 | 0 | 3 |
| DENND4A | ZNF25 | 0.668531 | 3 | 0 | 3 |
| DENND4A | PSMA5 | 0.665528 | 4 | 0 | 3 |
| DENND4A | UCHL5 | 0.664741 | 3 | 0 | 3 |
| DENND4A | THAP11 | 0.663747 | 4 | 0 | 4 |
| DENND4A | SLC44A1 | 0.663121 | 5 | 0 | 4 |
For details and further investigation, click here
