| Full name: DET1 partner of COP1 E3 ubiquitin ligase | Alias Symbol: FLJ10103 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 55070 | HGNC ID: HGNC:25477 | Ensembl Gene: ENSG00000140543 | OMIM ID: 608727 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DET1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DET1 | 55070 | 219641_at | -0.5598 | 0.4132 | |
| GSE20347 | DET1 | 55070 | 219641_at | 0.2290 | 0.3948 | |
| GSE23400 | DET1 | 55070 | 219641_at | -0.0477 | 0.3917 | |
| GSE26886 | DET1 | 55070 | 219641_at | -0.0903 | 0.8201 | |
| GSE29001 | DET1 | 55070 | 219641_at | 0.0829 | 0.7335 | |
| GSE38129 | DET1 | 55070 | 219641_at | -0.0976 | 0.6843 | |
| GSE45670 | DET1 | 55070 | 219641_at | -0.4072 | 0.0598 | |
| GSE53622 | DET1 | 55070 | 14991 | 0.0526 | 0.6128 | |
| GSE53624 | DET1 | 55070 | 14991 | 0.0770 | 0.2556 | |
| GSE63941 | DET1 | 55070 | 219641_at | -0.5646 | 0.4535 | |
| GSE77861 | DET1 | 55070 | 1558348_at | 0.0275 | 0.8425 | |
| GSE97050 | DET1 | 55070 | A_23_P26184 | -0.2057 | 0.3463 | |
| SRP007169 | DET1 | 55070 | RNAseq | 0.0013 | 0.9984 | |
| SRP064894 | DET1 | 55070 | RNAseq | -0.1703 | 0.4095 | |
| SRP133303 | DET1 | 55070 | RNAseq | -0.4620 | 0.0073 | |
| SRP159526 | DET1 | 55070 | RNAseq | 0.0263 | 0.9217 | |
| SRP193095 | DET1 | 55070 | RNAseq | -0.2552 | 0.1117 | |
| SRP219564 | DET1 | 55070 | RNAseq | -0.1322 | 0.8166 | |
| TCGA | DET1 | 55070 | RNAseq | -0.4907 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DET1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DET1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DET1 | 55070 | 7 | 3 | 20 | |
| GSE20123 | DET1 | 55070 | 7 | 3 | 20 | |
| GSE43470 | DET1 | 55070 | 5 | 4 | 34 | |
| GSE46452 | DET1 | 55070 | 3 | 7 | 49 | |
| GSE47630 | DET1 | 55070 | 8 | 10 | 22 | |
| GSE54993 | DET1 | 55070 | 4 | 6 | 60 | |
| GSE54994 | DET1 | 55070 | 7 | 6 | 40 | |
| GSE60625 | DET1 | 55070 | 4 | 0 | 7 | |
| GSE74703 | DET1 | 55070 | 4 | 3 | 29 | |
| GSE74704 | DET1 | 55070 | 4 | 2 | 14 | |
| TCGA | DET1 | 55070 | 16 | 12 | 68 |
Total number of gains: 69; Total number of losses: 56; Total Number of normals: 363.
Somatic mutations of DET1:
Generating mutation plots.
Highly correlated genes for DET1:
Showing top 20/542 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DET1 | ANAPC16 | 0.764874 | 3 | 0 | 3 |
| DET1 | CNRIP1 | 0.751053 | 3 | 0 | 3 |
| DET1 | ZNRF3 | 0.740618 | 3 | 0 | 3 |
| DET1 | ECSCR | 0.738275 | 3 | 0 | 3 |
| DET1 | FLNA | 0.738124 | 3 | 0 | 3 |
| DET1 | CYSLTR1 | 0.722801 | 3 | 0 | 3 |
| DET1 | IGSF10 | 0.71807 | 3 | 0 | 3 |
| DET1 | PALLD | 0.715042 | 3 | 0 | 3 |
| DET1 | C1QTNF7 | 0.714875 | 3 | 0 | 3 |
| DET1 | LRRN4CL | 0.711253 | 3 | 0 | 3 |
| DET1 | CYYR1 | 0.708444 | 3 | 0 | 3 |
| DET1 | ADARB1 | 0.707594 | 4 | 0 | 3 |
| DET1 | ST6GAL2 | 0.706827 | 3 | 0 | 3 |
| DET1 | NDUFA8 | 0.705646 | 3 | 0 | 3 |
| DET1 | INMT | 0.694866 | 4 | 0 | 4 |
| DET1 | PACSIN2 | 0.694636 | 3 | 0 | 3 |
| DET1 | AR | 0.691719 | 3 | 0 | 3 |
| DET1 | CYP4V2 | 0.691411 | 4 | 0 | 3 |
| DET1 | KCNT2 | 0.68844 | 4 | 0 | 3 |
| DET1 | SMTNL2 | 0.682501 | 3 | 0 | 3 |
For details and further investigation, click here
