| Full name: bone morphogenetic protein 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p12.1 | ||
| Entrez ID: 653 | HGNC ID: HGNC:1072 | Ensembl Gene: ENSG00000112175 | OMIM ID: 112265 |
| Drug and gene relationship at DGIdb | |||
BMP5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04390 | Hippo signaling pathway |
Expression of BMP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BMP5 | 653 | 205431_s_at | -0.3355 | 0.3891 | |
| GSE20347 | BMP5 | 653 | 205431_s_at | -0.0330 | 0.7249 | |
| GSE23400 | BMP5 | 653 | 205431_s_at | -0.1011 | 0.0060 | |
| GSE26886 | BMP5 | 653 | 205431_s_at | -0.1005 | 0.5776 | |
| GSE29001 | BMP5 | 653 | 205431_s_at | -0.0697 | 0.7565 | |
| GSE38129 | BMP5 | 653 | 205431_s_at | -0.2229 | 0.0129 | |
| GSE45670 | BMP5 | 653 | 205431_s_at | -0.2448 | 0.0848 | |
| GSE53622 | BMP5 | 653 | 133132 | -1.3891 | 0.0000 | |
| GSE53624 | BMP5 | 653 | 133132 | -0.5565 | 0.0015 | |
| GSE63941 | BMP5 | 653 | 205431_s_at | 0.3222 | 0.5982 | |
| GSE77861 | BMP5 | 653 | 205431_s_at | 0.2407 | 0.6673 | |
| GSE97050 | BMP5 | 653 | A_23_P19723 | -0.3507 | 0.4907 | |
| SRP133303 | BMP5 | 653 | RNAseq | -0.3511 | 0.4065 | |
| SRP159526 | BMP5 | 653 | RNAseq | 0.2724 | 0.6741 | |
| TCGA | BMP5 | 653 | RNAseq | -1.9021 | 0.0383 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by BMP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BMP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BMP5 | 653 | 9 | 1 | 20 | |
| GSE20123 | BMP5 | 653 | 9 | 1 | 20 | |
| GSE43470 | BMP5 | 653 | 5 | 0 | 38 | |
| GSE46452 | BMP5 | 653 | 2 | 10 | 47 | |
| GSE47630 | BMP5 | 653 | 7 | 5 | 28 | |
| GSE54993 | BMP5 | 653 | 3 | 2 | 65 | |
| GSE54994 | BMP5 | 653 | 9 | 4 | 40 | |
| GSE60625 | BMP5 | 653 | 0 | 3 | 8 | |
| GSE74703 | BMP5 | 653 | 5 | 0 | 31 | |
| GSE74704 | BMP5 | 653 | 5 | 0 | 15 | |
| TCGA | BMP5 | 653 | 21 | 13 | 62 |
Total number of gains: 75; Total number of losses: 39; Total Number of normals: 374.
Somatic mutations of BMP5:
Generating mutation plots.
Highly correlated genes for BMP5:
Showing top 20/324 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BMP5 | BBS1 | 0.726675 | 3 | 0 | 3 |
| BMP5 | CACNA1H | 0.701511 | 4 | 0 | 4 |
| BMP5 | DISC1 | 0.69809 | 3 | 0 | 3 |
| BMP5 | DACT3 | 0.685714 | 3 | 0 | 3 |
| BMP5 | NR3C2 | 0.675023 | 3 | 0 | 3 |
| BMP5 | SLC35E3 | 0.670548 | 3 | 0 | 3 |
| BMP5 | SHISA3 | 0.669387 | 3 | 0 | 3 |
| BMP5 | RBM24 | 0.669192 | 3 | 0 | 3 |
| BMP5 | SCG2 | 0.658 | 3 | 0 | 3 |
| BMP5 | NPTX1 | 0.656792 | 3 | 0 | 3 |
| BMP5 | PDZD4 | 0.65668 | 3 | 0 | 3 |
| BMP5 | ANK2 | 0.656098 | 3 | 0 | 3 |
| BMP5 | GKAP1 | 0.65468 | 4 | 0 | 3 |
| BMP5 | SYNE1 | 0.650894 | 3 | 0 | 3 |
| BMP5 | PPP1R14D | 0.650628 | 3 | 0 | 3 |
| BMP5 | NT5DC3 | 0.63921 | 5 | 0 | 3 |
| BMP5 | ITIH5 | 0.638852 | 3 | 0 | 3 |
| BMP5 | VIP | 0.63855 | 4 | 0 | 3 |
| BMP5 | AHI1 | 0.63509 | 3 | 0 | 3 |
| BMP5 | NCR2 | 0.634481 | 3 | 0 | 3 |
For details and further investigation, click here
